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Biomedical subjects

J Flament

Publications and source records attributed to J Flament.

At least 55 records · Page 3Linked to original sources
PubMed1990

[Candida albicans uveopapillitis. Diagnostic and therapeutic discussion apropos of a case].

Due to the difficulties encountered in the etiologie diagnosis of papillo uveitis along with the increasing occurrence of fungal infections (in paralleled with the number of AIDS affected patients), we found of interest to report a case of exsudative macular chorioretinitis with poor evolution under steroid therapy. In this patient infection by Candida Albicans was suspected and confirmed only after isolation and culture of the fungal from a vitrectomy specimen. A therapeutic apponch using Fluconazole (Triflucan allowed a dramatic improvement of visual acuity within a few months. Thus, vitrectomy appears as a decisive step in the diagnosis of endogenous ocular candidiasis. This diagnosis is even more difficult to suspect in patient without immun deficiency more any extraocular focal infestation.

Adult↗
PubMed1990

[Oculomotor paralysis and Lyme disease].

Lyme disease is an infectious multi system disorder caused by the spirochète Borrelia Burgdorferi. Neurologic syndromes occurring during the second stage of the illness are common and the neurologic feature is extremely variable. We report a case of Lyme disease with diplopia. In contrast with most reported cases of ocular motor involvement in Lyme disease, no other systemic symptoms were detected. The serodiagnosis, although mildly positive, was confirmed by western blot antibodies analysis and evaluation of CSF antibodies. Symptoms readily vanished 3 days after the introduction of antibiotherapy. The efficacity of antibiotic therapy on the quality and timing of functional recovery justifies the use of this therapy.

Adult↗
PubMed1989

[Diagnostic and therapeutic value of the panfundoscope in diseases of the posterior eye segment].

The scope of this work is to evaluate the diagnostic and therapeutic value of using Schlegel's panfundoscope with respect to the three mirror lens on the basis of a double-blind comparative study. This method is especially rewarding for the follow-up of fundus lesions, their detection through opaque media and/or a poorly dilated pupil, as well as through an intraocular lens. Panretinal photocoagulation, prophylactic annular photocoagulation of peripheral retina and vitrectomy can be performed more easily through this lay-out.

Double-Blind Method↗
PubMed1989

[Intra-ocular implantation and traumatic cataract].

Discussion of the indications of the correction of post-injury aphakia intraocular lens. The immediate infectious danger by perforation, the unavoidable inflammatory reactions, the potential retinal risk and the so often alteration of the posterior chamber by synechias, are leading to advice, in the majority of cases, the secondary anterior chamber lens implantations.

Cataract↗
PubMed1988

Effect of the 5-lipoxygenase inhibitor piriprost on superoxide production by human neutrophils.

The effect of 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-prostaglandin I1 (Piriprost) on the oxidative response was studied in human neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine (fMLP), phorbol 12-myristate, 13-acetate (PMA) or opsonized zymosan. Piriprost inhibited the stimulatory effect of fMLP on superoxide anion (O2-) generation, at concentrations higher than those which depress leukotriene B4 (LTB4) formation. This inhibition was overcome by increasing the concentration of fMLP. Neither exogenous LTB4 nor indomethacin were able to reverse the inhibitory effect of piriprost on fMLP action. In contrast, piriprost did not inhibit the stimulation of O2- production induced by PMA or zymosan. Piriprost behaves thus as a specific and apparently competitive antagonist of fMLP: this action does not seem to involve lipoxygenase inhibition and might be exerted at the level of the fMLP receptor or its associated mechanisms of transduction.

Arachidonate Lipoxygenases↗
PubMed1987

Pregnancy and humoral immune response in mice chronically infected by Trypanosoma cruzi.

The effect of pregnancy on the humoral immune response induced by Trypanosoma cruzi was studied in groups of chronically infected and pregnant mice (IP) or chronically infected and nonpregnant mice (INP) of strain BALB/c. Groups of noninfected and nonpregnant mice (NINP) or noninfected and pregnant mice (NIP) served as controls. The pregnant mice were killed on day 17 of pregnancy. Anti-T. cruzi immunoglobulin G (IgG) and IgM antibodies, detected by immunofluorescence or enzyme-linked immunosorbent assay or both, underwent a pregnancy-associated decrease of 20 to 40%, whereas complement-mediated lytic antibodies were unaffected by pregnancy. Immunoblotting analysis indicated identical specificities of the anti-T. cruzi antibodies in IP and INP groups. The levels of all the immunoglobulin isotypes (particularly IgG2a and IgG3), circulating immune complexes, rheumatoid-like factor, and anti-DNA antibodies were considerably increased during chronic infection (NINP versus INP), which could be related to the high degree of polyclonal B-cell activation occurring in T. cruzi infection. However, pregnancy significantly decreased (by 20 to 60%) such parameters. IgG levels were particularly affected (by 40 to 60%), and the decreases could be ordered as follows: IgG3 greater than IgG2a greater than IgG1 greater than IgG2b for IP versus INP. Comparisons between the noninfected groups indicated differences only in IgG levels. These results indicate the following. (i) The specific humoral anti-T. cruzi immune response is weakly affected by pregnancy, which is not sufficient to modify the course of the mother's infection. (ii) Pregnancy does not modify the expression of the anti-T. cruzi antibody repertory. (iii) Pregnancy reduces the polyclonal B-cell activation, particularly the levels of the IgG isotypes undergoing the greatest activation.

Animals↗