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J Dreyfus

Publications and source records attributed to J Dreyfus.

At least 37 records · Page 2Linked to original sources
PubMed1986

Maturation signs of the cervix and prediction of preterm birth.

A prospective study was conducted on 7937 pregnancies, 4430 of which had prenatal visits before 37 weeks of gestation. Induced preterm deliveries were excluded (N = 40). Then the data was incorporated from the visits (cervix status, uterine contractions) as well as some common indicators of risk for preterm birth (mother's age, social status, obstetric antecedents, bleeding) into a predictive scoring system for spontaneous preterm labor. Different scores were computed according to both parity and to the timing during pregnancy when the signs were observed. It was found that approximatively 25% of the total preterm births were connected with the presence of at least one of three maturation signs of the uterine cervix (dilation of the internal os to 1 cm, cervical length less than 1 cm, and presence of painful uterine contractions).

Adolescent↗
PubMed1986

[Variations in birth weight as a function of various fetal and maternal characteristics. The application to the diagnosis of hypotrophy].

The known variations in weight for gestational age as well as compounding maternal and/or fetal factors, puts into question the usual definition of small for gestational age (SGA) which is based on gestational age alone. On the basis of more than 20,000 births studied in 4 maternity hospitals from 3 separate regions in France, the authors propose a new definition for growth retardation in full-term babies, taking into account 4 factors: gestational age, sex, birth rank, height and usual weight of mothers. This definition allows constitutionally SGA newborns to be considered normal, while some babies previously classified as normal would now lead one to suspect intra-uterine growth retardation (IUGR). This approach tries to take constitutional and environmental risk factors into account in fetal growth hopefully allowing for help better detection of IUGR.

Adult↗
PubMed1985

Prevention of preterm births: a perinatal study in Haguenau, France.

A reduction in preterm births has been observed in Haguenau (Eastern France) during a 12-year intervention study with a program for prevention of preterm deliveries. The Perinatal Study of Haguenau was an observation tool used in a stable population, and it allowed measurement of the way women have progressively responded to the new proposals in prenatal care. It also allowed measurement of the results of the interventions: low birth weight (less than 2,500 g) and preterm birth rates (less than 37 weeks of gestation) among single live births. The total duration of the study was divided into three periods of four years (1971 through 1974, 1975 through 1978, and 1979 through 1982), for which the numbers of single live births are 5,763, 4,957, and 5,919, respectively. For the same periods, the low-birth-weight rates, 4.6%, 4.0%, and 3.8%, respectively, showed a significant decrease (P less than .001). Following a similar pattern, the rates of preterm birth were 5.4%, 4.1%, and 3.7% (a significant reduction with P less than .001). These improvements in pregnancy outcome do not disappear after standardization of mother's age, high blood pressure, or social class distribution. These findings, which concur with the results of others, enhance the hypothesis of a direct relationship between a prevention program and a reduction in preterm birth rates.

Birth Weight↗
PubMed1985

[Long-term outcome of children who were prematurely born or small for gestational age].

All children born between 1971 and 1974 at the Haguenau maternity center (Lower-Rhine department, N.E. France) and attending school in Haguenau were examined by school doctors. The paper shows that there were differences in development of the 3 groups studied: 54 children born before term, 62 born small-for-dates and 1,188 controls. The rapid growth rate observed in the preterm children enabled them to catch up with the controls in physical growth criteria, in contrast to those in the small-for-dates group. Overall, those in the preterm group seemed to enjoy better health than those in the small-for-dates group, but their adaptation to school life was poorer.

Child↗
PubMed1984

Multicentred controlled trial of cervical cerclage in women at moderate risk of preterm delivery.

A total of 506 women at moderate risk of preterm delivery were randomly allocated to either cervical cerclage or a control group. Significantly more women in the group allocated to cerclage were admitted to hospital for reasons other than the operation and more received oral tocolytic drugs. There were also more caesarean sections and more preterm deliveries in the women allocated to cerclage although the differences between the two groups were small and not statistically significant.

Adult↗
PubMed1984

[Fetal hypotrophy. Statistical analysis of placental changes].

The purpose of this research was to study the relationship between placental characteristics and the degree of failure of growth between 37 and 41 weeks of pregnancy. The cases of severe small-for-dates (percentiles of 1 to 5) and moderate small-for-dates (percentiles of 6 to 10) were compared with a control series (percentiles of 11 to 90) with an equivalent gestational age. In both groups of small-for-dates babies one could find that the chorionic arteries and their trunks were of a lower diameter than those of the villi that were small and that there were sub- chorial deposits of fibrin in both groups. The greater number of placental abnormalities were found in those babies who were severely small-for-dates at a gestational age of between 37 and 39 weeks. The relationship between acute fetal distress and small for dates was analysed. There was little difference in the likelihood of fetal distress between the two groups of small-for-dates babies, but there were differences between both groups and the control group.

Female↗
PubMed1979

Comparison of two successive policies of cervical cerclage for the prevention of pre-term birth.

The percentage of women receiving cervical cerclage increased from 5% to 18% between two periods at Haguenau maternity hospital, according to a new policy for the prevention of pre-term birth. A parallel reduction of premature deliveries by about a half was observed in the relevant group of women. This suggests that cerclage might be employed on another basis than is currently the case, and that a randomized trial is urgently needed to define its indications more precisely.

Cervix Uteri↗
PubMed1979

[Antenatal diagnosis of the sex of the fetus by diagnostic ultrasound (echography) (author's transl)].

The authors present the results they obtained in diagnosing fetal sex in utero by the use of real-time echography. They also have reviewed the other different techniques for the diagnosis and their fallibility. The prediction of fetal sex is possible in 90 p. 100 of echographies carried out routinely. When a very careful well codified technique is used the method becomes highly reliable. In a successive series of 103 pregnancies fetal sex was diagnosed correctly in every case. The authors point out that they diagnose female sex through positive echographic finding and not by a process of exclusion of the male organs.

Amniotic Fluid↗
PubMed1978

[A new family with mutation of the structural gene of human ornithine carbamoyltransferase].

Studies of a child with hyperammonemia have demonstrated a deficiency in OCTase. The kinetic properties of the enzyme were studied and it could be shown that we have to deal with a new mutation which is different from the ones previously known. It is a mutation of the structural gene. The detection of a heterozygote is possible when the urinary orotic acid excretion is studied after a loading meal (2g of proteines per kilo of weight). A child with hyperammonaemia due to ornithine transcarbamylase deficiency is described. A new structural gene mutation is probable because the kinetic properties of the enzyme are different to previously described variants. The heterozygote could be detected by the measurement of the excretion of orotic acid in the urine following a protein load of 2 g/Kg.

Amino Acid Metabolism, Inborn Errors↗
PubMed1977

Smoking during pregnancy and placental pathology.

The pathological study of all placentas from women smoking at least five cigarettes daily during pregnancy (248 cases) and of those placentas from a corresponding control group randomised among all the non-smokers (196 cases) has been set up at the maternity hospital of Haguenau (France) since 1974. The systematic histological examination has shown among smokers a higher frequency of abonormal trophoblast and especially of nuclear clumps in the syncytiotrophoblast. On the other hand, according to a standard protocol, the grouping of various abnormalities has shown, among smokers, a higher frequency of "signs of hypoxia". The lack of relationship between these "signs of hypoxia" and the well-known decreased birthweight among smokers suggests that smoking during pregnancy could always go with a decreased birthweight without a corresponding decreased placental weight, and seldom with an intra-uterine hypoxia. These two effects are independent.

Adult↗
PubMed1977

[Distribution of birth weights and influenza epidemics (author's transl)].

The possible consequences of influenza during pregnancy on the weight of the new born were studied. It was shown that the major 1969-70 winter influenza epidemic in Alsace was followed by a decrease in the mean birth weight registered in Haguenau's maternity hospital. This study confirms previous work on the subject and shows that birth weight can be used as a valuable tool at the epidemiologic scale.

Birth Weight↗