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Biomedical subjects

J Dreyfus

Publications and source records attributed to J Dreyfus.

At least 55 records · Page 3Linked to original sources

[Sero-epidemiology of infections due to cytomegalovirus by indirect hemagglutination technic].

Applied to cytomegalovirus, the technique of indirect hemagglutination offers a good sensitivity and reliable specificity for serological testings. Improvements in the standardization are however still required. Sero-epidemiological studies performed in different groups of children and carried out with this method led to the following results: mother-child contagium, early infection in young infants, and influence of socio-economical and ethnical factors. Studies performed on pregnant women showed that the risk of infection decreased after the first pregnancy.

Adolescent↗

Smoking, human placental lactogen and birth weight.

Human placental lactogen (HPL) was measured in 525 serum samples from 144 pregnant women and related to smoking habits and the birth weight of their infants. Women smoking during pregnancy were found to have a level of HPL significantly lower than the non-smokers (p less than 0.05). A significant correlation between HPL and birth weight was found (r=0.38); p less than 0.001) which remained significant when smoking was held constant (r=0.35; p less than 0.001). There was no relationship between birth weight and smoking when HPL was held constant.

Birth Weight↗

Individual correction of birth weight for parental stature with special reference to small-for-date and large-for-date infants.

The aim of the present paper is to determine how parental stature measurements should be used to "correct" birth weight in order to improve the diagnosis of small or big-for dateness. A first approach, based on the pattern of coefficients of correlation between maternal and paternal weight and height, and birth weight (Tab. I), may be criticized for two reasons: 1) it does not take into account the possible variations of this pattern of correlations from one subcategory (for instance of age) of the sample to another and ii) it makes no difference between "genetic" and "environmental" components of parental influence on birth weight. A second approach takes into account the variations of parental stature measurements, of birth weight and of the pattern of correlations according to mother's age (Tabs. II and III). Briefly: The correlation between birth weight and mother's weight increases, the correlation between birth weight and father's weight decreases when mother's age increases (except for mother's older than 34), and these coefficents have the same value in the youngest group (mothers less than 21). These observations are consistent with the hypothesis of the predominance of the "genetic" component in the youngest group, which leads to the establishment of the coefficients to apply to each parental stature measurement by means of a multiple regression analysis carried out on this only group (Tab. IV). For the whole population, the correction must finally be calculated using the weights of parents at 20 years (or, if unknown, an approximate value). The correction is about ten grams per kilogram of mother's and eight grams per kilogramm of father's weight deviations from the mean values of the population to which they belong.

Adolescent↗

Prevention of preterm birth and perinatal risk reduction.

A reduction in preterm births has been observed in Haguenau, eastern France, during a 12-year intervention study on prevention of preterm deliveries. Between 1971 and 1982 there was also an increase in the proportion of women who attended the prenatal clinic in the first trimester, and an increase in the mean number of visits in the first 6 months of pregnancy. These changes were observed in women of all educational levels. This investigation illustrates the use of time-trend studies in the field of health technology assessment.

Educational Status↗

[Grippe and pregnancy. Relation of birth weight to placenta weight].

The different results that have been published concerning the problem of the final outcome for patients who have had influenza during pregnancy reported in numerous works might be explained by differences in methodology used by the different authors. A study was carried out in the Haguenau Maternity Hospital (Bas-Rhin) when an epidemic of influenza occurred in 1972-173. The virological diagnosis was made by carrying out separate serological estimations on 1940 pregnant women. It can be shown that the mean birthweight dropped in infants of mothers who had contracted influenza during pregnancy even when corrections were made for sex and the duration of the pregnancy. The drop in weight of the placenta (37.3 g as a mean) was more obvious and can totally explain the drop in fetal weight. It was not possible to demonstrate any increase in the number of congenital malformations that were found in the neonatal period in the infants born to women who had had influenza. These results suggest that there is no direct passage of the influenza virus across the placenta which, however, is itself modified by the infection.

Animals↗