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Biomedical subjects

J Diebold

Publications and source records attributed to J Diebold.

At least 289 records · Page 16Linked to original sources
PubMed1981

[Non lymphoid cells of the peripheral lymphoid organs. Recent morphological progress and current understanding (author's transl)].

Peripheral lymphoid organs have two groups of non lymphoid cells : that of macrophages which belongs to R. van Furth's system of mononuclear phagocytes and the one made of elements for long labelled "reticular cells". The use of electron microscopy has permitted a good understanding of these elements and a recognition of ubiquitary cells (fibroblasts, endothelial cells) and specific cells to the lymph node which seem to play a very important role in the immune reactions (interdigitated cells, reticulum cells, dendritic cells). We describe their light and electron microscopical features and histoenzymatic characters, and present the actual concept of their origin and function. The latest discoveries on their classification are reviewed and have permitted to distinguish three categories of non lymphoid cells : first the group of reticulum cells (reticulum cells and dendritic cells), second that of mononuclear phagocytes (macrophages and interdigitated cells) and third that of endothelial cells. Other elements of questionable existence or insufficiently known do not appear in this classification : dark cells, Steinman and Cohn's dendritic cells and cells containing Birbeck's granules.

Humans↗
PubMed1981

[Pseudo-lymphomas of the ocular adnexa: their relations to Sjögren's syndrome (author's transl)].

Studies over the last fifteen years, of histological, immunological and hematological parameters has, led to the description of a non-malignant lymphoproliferation: a pseudo-lymphoma which is in the middle of the spectrum between glandular localisation of Sjögren's syndrome and frank neoplasia. This type of proliferation has been also observed in the conjunctiva, without antecedents of Sjögren syndrome. Histologically and immunologically, it is dysimmunitary process which has the potential to regress with appropriate immunosuppressive therapy, or to progress to malignant lymphoma.

Adult↗
PubMed1981

[Malignant lymphoplasmocytic lymphoma of the orbit and conjunctiva (author's transl)].

New functional classifications of malignant lymphomas have demonstrated the relative frequency of malignant lymphoplasmocytic lymphoma of the orbit. The tumors, which show the particular characteristic of secreting monoclonal immunoglobulins, and which may follow a Sjögren's syndrome or a pseudolymphoma, could represent a localized form of Waldenström's disease. They have a relatively favorable prognosis, however, if recognized at a sufficiently early stage.

Adult↗
PubMed1980

Lymphoblastic lymphoma/leukemia with convoluted nuclei: the question of its relation to the T-cell lineage studied in 13 patients.

This work is devoted to the analysis of the nature of lymphoblastic lymphoma/leukemia with convoluted nuclei which were initially described by Barcos and Lukes. Ultrastructural, cytochemical, and immunologic features of tumor cells were investigated in patients chosen according to known morphologic criteria. Through results of the E rosette test, the patients were divided into two groups (E+ and E-). In the E+ group, the predominant features were sex (only men), the mediastinal localization, and the focal positivity of the acid phosphatase reaction. Cytotoxicity tests with rabbit antihuman T-lymphocyte anti-serum confirmed the results of the E rosette test in the 3 patients of the E+ group who were tested and were also positive in 2 patients from the E- group (1 of these 2 patients had the characteristics found in the E+ group and can thus be related to this group; the other patient had none of these characteristics). This raises the question of a leukemia arising from a less differentiated T-cell but this interpretation is limited by the specificity of the anti-T-serum. Ultrastructural study defines more precisely the convoluted aspect but does not at present allow a distinction between the two groups.

Adolescent↗
PubMed1980

[Orbital immunoblastosarcoma (author's transl)].

The new classifications adopted for lymphoid tumors now include a particular type of proliferative process: immunoblastosarcoma. This tumor is not a rare occurrence in the orbit, as shown by the two cases reported, and possesses sufficiently specific clinical and histologicas characteristics to justify its appearance in a separate class. The cytological and histological characteristics of the immunoblasts from which it develops are described. Tumors of this type were previously mostly included in the group of reticulosarcomas, now become obsolete because of poorly defined characteristics of the reticular cell. The prognosis is poor in spite of the chemotherapeutic and radiotherapeutic treatments proposed.

Aged↗
PubMed1980

Angiofollicular and plasmacytic polyadenopathy: a pseudotumourous syndrome with dysimmunity.

Two cases are reported of an apparently distinct type of immune disorder. Beginning with mild anaemia and widespread massive lymphadenopathy, the disease progressed to a fatal autoimmune type haemolytic anaemia. Serum investigation showed polyclonal hypergamma-globulinaemia and some autoantibodies. Repeat lymph node biopsies in each case showed hyperplasia within B lymphocyte territory (follicular hyperplasia and polyclonal plasmacytosis with IgG predominance) and atrophy of T dependent areas. Dilatation of lymph sinuses, vascular proliferation, and sclerosis were striking features. This appears to be a new entity, and reasons are given for separating this disease from other pseudotumourous lymph node disorders associated with dysimmunity.

Aged↗
PubMed1980

[Anatomo-pathologic study of biopsies taken in 250 exploratory laparotomies for Hodgkin's disease].

During systematic laparotomies in patients with Hodgkin's disease, the spleen is removed and multiple visceral biopsies (lymph nodes, liver, bone marrow) are done. In 58,8% of the cases, the spleen is normal. In 41,2% of the patients, the spleen shows localizations of Hodgkin's disease. A tumoral spleen has sometimes a normal size (34,9% of the involved spleen). A huge spleen is not always involved by tumoral lesions (10% of the spleens without tumor). When the spleen is tumoral, lymph node involvement is more frequent and more diffuse. Generally the liver is not involved when the spleen is not tumoral. Hepatic tumoral localizations are disclosed by biopsies in 16% of the patients with splenic involvement. Bone marrow localization is found in 5,7% of the cases with splenic involvement. So exploratory laparotomy were precise pathological studies allow a better appreciation of the real extension of the lesions in Hodgkin's disease.

Adult↗
PubMed1980

[Visceral Kaposi sarcoma with angioimmunoblastic lymphadenopathy and latent sicca syndrome (author's transl)].

A case clinically and morphologically typical angio-immunoblastic lymphadenopathy in a 64-year old man is reported. A sicca syndrome was discovered with histological localization in the labial accessory salivary glands. Death occurred after a course of a few months. The autopsy showed an association of angio-immunoblastic lymphadenopathy lesions of the bone marrow and the lymph node and of typical multivisceral localizations of Kaposi's sarcoma (lymph node, liver, thyroïdd gland) without skin involvement. This association of two diseases characterized by severe dysimmunity with B lymphocytes hyperplasia is discussed, and compared to the others diseases which could be associated with Kaposi's sarcoma.

Female↗
PubMed1979

Ultrastructural and immunocytochemical localization of immunoglobulin synthesis in tumor cells in Hodgkin's disease.

An immunocytochemical and ultrastructural study using the Fab fragment of an anti-human Ig antibody labelled with peroxidase was carried out on affected lymph nodes from five Hodgkin's disease patients. The tumor cells (Reed-Sternberg cells and Hodgkin cells) showed an exclusively hyaloplasmic granular staining. By comparing these grains with ribisome staining. By comparing these grains with ribosome staining of the endoplasmic reticulum of plasma cells it could be suggested that they are free risobomes. This ribosomal Ig synthesis is a major argument for the B lymphocyte nature of Reed-Sternberg and Hodgkin cells. The total absence of vacuole staining allows us to conclude that these cells are not histiocytic or macrophage derivatives.

Cytoplasm↗
PubMed1979

Atypical T-cell leukemia terminating Hodgkin's disease.

A case of Hodgkin's disease is described which developed into a terminal illness characterized by a malignant proliferation of T-cells. The leukemic cells, after optical and ultrastructural analysis, were distinct from those of myelomonocytic, acute lymphoblastic, chronic lymphocytic as well as prolymphocytic leukemia. Their relationship with the T-cell lineage seemed to be confirmed by a highly positive E-rosette test and by cytochemistry which showed focal positivity of acid phosphatase. The importance of this T-cell malignant proliferation is discussed, especially with regard to cellular interactions in Hodgkin's disease.

Acid Phosphatase↗