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Biomedical subjects

J Diebold

Publications and source records attributed to J Diebold.

At least 271 records · Page 15Linked to original sources
PubMed1984

[Autotransplantation of the spleen. Experimental study in rats. Histology and anti-infectious role of infected splenic tissue].

Experimental study on splenic autotransplantation into the retroperitoneum and an epiploic pouch in the rat. Histologic examination of the splenic transplants was performed 5, 8, 14 days, 3, 4, 5, 6, 9, 12 weeks and 7 months after operation. Study of the immunologic efficiency of the transplant after intravenous injection of the bacteria Pneumococcus and Staphylococcus aureus.

Animals↗
PubMed1983

[Gougerot-Sjögren syndrome, periarteritis nodosa, non-Hodgkin's lymphoplasmocytic lymphoma and acquired C4 deficiency].

A Sjögren syndrome was confirmed histologically in a 19 year old woman. Four years later, periarteritis nodosa (PAN) with characteristic vascular lesions on muscle biopsy occurred simultaneously with lymphatic hyperplasia comprising splenomegaly and polyadenopathy. The PAN was cured with corticosteroids and cyclophosphamide and the lymphadenopathy regressed. Several months after treatment was stopped the lymphadenopathy recurred which histologically resembled a malignant non-hodgkin lymphoplasmocytoma secreting an IgM kappa monoclonal immunonoglobulin. During the PAN and the establishment of the lymphoproliferative syndrome a severe C4 deficit was detected which disappeared after chemotherapy.

Adult↗
PubMed1983

Peliosis of the spleen. Report of a case associated with chronic myelomonocytic leukemia, presenting with spontaneous splenic rupture.

A 62-year-old man had chronic myelomonocytic leukemia (untreated) for a period of 8 years. He developed a sudden, spontaneous rupture of the spleen and a splenectomy was performed. Grossly and microscopically the spleen showed peliosis. The blood-filled cavities were similar to the pseudosinuses described in the spleen of hairy-cell leukemia. The lesion common to these disorders apparently is a progressive disappearance of lining cells and of ring fibers.

Adult↗
PubMed1983

[Morphologic methods in the study of lymph nodes].

A good histopathological study of lymph node biopsies is only possible if the structure and the cell morphology are well preserved. It is necessary, therefore, to ensure that the material is correctly handled from the onset of the investigation. The method of bisection, the fixation procedure, the paraffin and plastic processing, the staining techniques are exposed with practical details. The investigation of lymphoid tissue requires a multiparameter approach. Additional data can be obtained from other techniques, for example cytology, histoenzymology, immunohistochemistry, electron microscopy. These techniques are described so that they can be undertaken in routine pathology.

Biopsy↗
PubMed1983

T-cell origin of Lennert's lymphoma. Immunohistochemical and immunologic study of one case.

We observed a patient with Lennert's lymphoma. Immunocytochemical study of paraffin sections by the immunoperoxidase technique and immunologic study of viable cell suspension by monoclonal antibodies confirmed the T-cell nature of the neoplastic lymphoid cells. Subtyping showed a predominance of helper T lymphocytes. The histiocytic nature of the epithelioid-cell component of Lennert's lymphoma was also shown by immunostaining.

Cell Transformation, Neoplastic↗
PubMed1983

[Reactive hyperplasia and pseudo-lymphomas with hypergammaglobulinemia. I. Benign lymphadenopathies].

The association of adenopathies, having sometimes a tumoral aspect, and a polyclonal hypergammaglobulinemia in the blood can be observed in various illnesses. In all these diseases the increase in the volume of the lymph nodes is partly due to the hyperplasia of the lymphoid B regions. Lymph node biopsy allows a precise diagnosis to be made, providing a thorough analytical study of the histopathological lesions is performed. In this first part, the histopathological lesions of benign lymphadenitis, having a pseudo-tumoral aspect from a clinical view, are described. The following are thus successively studied: sarcoidosis; acquired toxoplasmosis; the various aspects which can be attributed to infectious mononucleosis; vaccinal reactions; the Destombes-Rosai-Dorfman syndrome or massive lymphadenopathy by sinusal histiocytosis with hemophagocytosis; angiofollicular lymphoid hyperplasia or pseudo-tumour of Castleman; angio-follicular and plasmocytic polyadenopathy; the adenopathies of collagenosis and those due to protein deposits. For each disease, the morphological data are discussed and compared to clinical state and biological modifications.

Adult↗
PubMed1983

[Cutaneous necrosis of the breast: a complication of oral anticoagulant treatment].

Cutaneous necrosis of the breast is a rare complication of oral antivitamin K drugs. It occurs shortly after instituting therapy with well-limited, irreversible skin necrosis developing rapidly. The scar is superficial and only involves the subcutaneous tissue; early and extensive surgery does not therefore seem to be justified. Normal scarring is the eventual spontaneous outcome but this is always a long process. Several arguments are advanced in favour of a toxic effect of the drug itself on the vascular walls of the vessels in the dermis.

Administration, Oral↗
PubMed1983

[Thrombotic thrombopenic purpura associated with Hodgkin's disease].

We report the second case of Hodgkin's disease associated with thrombotic thrombocytopenic purpura (TTP). Although the two diseases coexisted originally, TTP was diagnosed alone at first. Because of the very rare occurrence of this association the diagnosis of TTP is discussed according to the accepted criteria and taking into account the haematological complications which can reveal or be observed in Hodgkin's disease. No evident relationship between the two diseases can be suggested. But immunologic disorders observed in the two cases suggests that their coexistence is not necessarily accidental. The evolution of these two diseases is particularly good.

Adult↗
PubMed1982

[Haemophagocytic sinus histiocytosis or Destombes-Rosai-Dorfman syndrome (author's transl)].

Haemophagocytic sinus histiocytosis usually presents as cervical lymphadenopathy developing in a context of severe inflammatory reaction. The lymph nodes contain numerous large cytophagic histiocytes capable of absorbing all kinds of blood cells, and diffuse plasmocytic infiltrates. Other organs may be involved, notably the skin and bones, as in the case presented here. The course of the disease if prolonged, irrespective of the treatment administered.

Bone Diseases↗
PubMed1982

[Early evaluation of therapeutic response in acute lymphoblastic leukaemia. A study of cytoreduction in blood and bone marrow (author's transl)].

Cytoreduction was evaluated during the first week of induction treatment in 29 adult patients with acute lymphoblastic leukaemia. In 25 patients a slope of decrement of circulating blasts between the 1st and 7th days of treatment could be drawn on a semilogarithmic scale. The fall of the medullary blast index was calculated in bone marrow obtained by aspiration in 17 cases and by aspiration plus biopsy in 11 cases. The diminution of circulating and medullary blasts was more pronounced in patients who achieved complete remission than in those who failed to respond (p less than 0.001), irrespective of the induction treatment. Early therapeutic cytoreduction, as measured by these simple mathematical methods, therefore has a bearing on the prognosis, and the induction treatment should be reinforced in cases where cytoreduction is insufficient.

Adult↗
PubMed1982

Lysosomal localisation of parallel tubular arrays in chronic lymphocytic leukaemia of T cell origin: an ultrastructural cytochemical study.

An ultrastructural cytochemical study of lysosomal acid phosphatase was performed on leukemic cells in a case of chronic lymphocytic leukaemia of T cell origin (T-CLL). The cells showed inclusion bodies known as parallel tubular arrays, which often lay within acid phosphatase-positive, membrane-bound spaces. This suggests their lysosomal location.

Acid Phosphatase↗