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Biomedical subjects

J Diebold

Publications and source records attributed to J Diebold.

At least 307 records · Page 17Linked to original sources
PubMed1977

[B-lymphocyte origin of the Reed-Sternberg cell. Immunoelectronmicroscopical arguments (author's transl)].

Some direct and indirect arguments are at present in favour of the B-lymphocyte origin of the Reed-Sternberg (R.S.) cell. Immunoperoxidase methods applied to paraffin sections permit to identify immunoglobulin components in their cytoplasm, but these results are not suffisant to prove that the R.S. cell synthesizes immunoglobulins. We have applied immunoelectronmicroscopic methods to a lymph node in a case of Hodgkin's disease. The results permit us to found intracellular immunoglobulins in the R.S. cell and to evoke a probable synthesis of immunoglobulin by free ribosomes, thus agreing the B-lymphocyte nature hypothesis of the R.S. cell.

B-Lymphocytes↗
PubMed1977

[Carcinoma of the nasopharynx in the young subjects. Clinical, pathological and ultrastructural study of 50 cases in Eastern Algeria (author's transl)].

Africa, and in particular North Africa, is a site of high prevalence of carcinoma of the nasopharynx in the young subject. There is a marked male predominance and a clear peak of incidence between 15 and 25 years. The presenting feature is usually rapidly growing cervical lymphadenopathy. The diagnosis is based upon histological examination of these nodes. It is a squamous carcinoma, usually highly undifferentiated and difficult to identify. However, for the experienced observer, the special appearance of tumour proliferation makes it possible to localise the primary tumour in the epi-pharyngeal region. Current work is aimed at research into a possible genetic predisposition and the relationship which the carcinoma may have with the Epstein-Barr virus.

Adolescent↗
PubMed1977

[Hairy cell leukemia in the spleen (author's transl)].

Fifteen spleens with hairy cell leukemia are studied with immunofluorescent (7 cases), electron microscopic (5 cases), and usual histologic methods. The findings are: enlargment of the spleen (weight always superior to 400 g), diffuse red pulp infiltration by ambiguous cells with regular repartition of nuclei and clear spaces between them, hairy aspects of the cytoplasmic membrane which are especially observed on semi-thin and ultra-thin sections, presence of particular cytoplasmic inclusion bodies (polysome lamellae complex). The cellular infiltration is accompanied by some vascular modifications: pseudo angiomatosis lesions, nodular formations ressembling splenomas. An important hypertrophy of the splenic macrophages with erythrophagocytosis and siderosis is also observed. These two phenomena partly explain the anemia.

Erythrocyte Aging↗
PubMed1977

[Bone-marrow biopsy in Hodgkin's disease].

In 349 subjects with Hodgkin's disease 520 bone marrow biopsies were carried out: 454 did not lead to the discovery of any tumour (87.5%), 66 permitted us to discover a tumour (12.5%). Among the bone marrows without Hodgkin tissue, the hematopoietic tissue was normal in 233 bone marrows (51.2%), hyperplastic in 157 bone marrows (34.7%), hypoplastic or aplastic in 64 bone marrows (14%). Eosinophilia was noted in 13% of cases, marked plasmacytosis was noted in 24%. Among the cases with a tumour, 89.2% showed a massive lesion; 10.7% showed partial lesions. The frequency of involvement was 5.4% for clinical stages I. 6.2% for stage II. 17.1% for stage III. 47.6% for stageIV. Bone marrow involvement at the start of the disease was found in 3% of cases, even in stages I and II. The involvements were especially frequent in the histological forms, stage III (19.4%) and IV (30.4%). In splenectomised patients, bone marrow involvement was 5 times more common when the spleen was also involved. 50 times more common when the liver was involved. The bone marrow which may be used to detect hematogenic spread of Hodgkin's disease is an investigation which should be carried out as a routine in the early stages of the disease and whenever a relapse is suspected.

Adult↗
PubMed1977

[Morphological aspects of the bone marrow in hairy-cell leukemia].

Bone marrow plays a considerable role in the diagnosis of hairy cell leukemia. The morphological aspects should be well known. One should emphasize the existence of aplastic or hypoplastic forms requiring one to repeat biopsy on the slightest clinical suscpicon. Routine histological techniques are sufficient for the diagnosis. The ultrastructural study also provides valuable histological and cytological evidence.

Adult↗
PubMed1977

[Bone-marrow biopsy in chronic myeloid leukemia. Value of the initial examination].

In 31 patients with chronic myeloid leukemia, the initial bone marrow biopsy constantly showed considerable cell richness. The maturation of the granulocytes was harmonious in 52% of cases, with a predominance of myelocytes in 32% of cases, and groups of myeloblasts in 13% of cases. Eosinophilia was frequent and fairly intense. Fairly numerous loaded cells and Charcot-Leyden crystals were signs of granulocyte failure in the bone marrow. The erythroblasts were reduced, the megakaryocytes increased. Myelofibrosis was present in 45% of cases. This gave a very characteristic histological appearance. It was not possible to draw up correlations between the type of granulocyte maturation and/or the presence of myelofibrosis and, on the other hand, the clinical course of the disease, but the small number of case studied both in our series and in the literature do not permit one to carry out a proper statistical study.

Biopsy↗
PubMed1977

[Bone-marrow biopsy in chronic myeloid leukemia. Significance during development].

In 29 patients bone marrow biopsy carried out during the course of chronic myeloid luekemia, permitted the authors to divide up the patients into 5 histologically different groups according to the association of 3 parameters: the richness in granulocytes, the state of the matrix, the degree of leukoblastosis. There was, in most cases, correspondence between the histological appearance and the clinical and laboratory symptoms. This was particularly clear when the patient entered the terminal phase of the disease. 4 of the 5 histological groups had an unfavourable short-term prognosis, i.e., granulocyte hyperplasia with myelofibrosis, aplasia with normal matrix or with myelofibrosis and massive leukoblast invasion.

Adult↗
PubMed1977

[A study in immunofluorescence of the plasma cells in allergic conjunctivitis, in particular of the cells forming immunoglobulin E (IgE) (author's transl)].

The relatively simple and precise technique of direct immunofluorescence on a tissue section enables the study and enumeration of all types of plasma cells including mastocytes (stained with acridine orange) in normal conjunctiva (5 cases), chronic non-allergic conjunctivitis (5 cases), allergic conjunctivitis of the educt (11 cases) and vernal conjunctivitis (11 cases). There is evidence of elevation of IgE plasma cells in type I allergic conjunctivitis where they are twice as raised as in non-allergic cases in adult forms, and three times more elevated in vernal conjunctivitis. There was no correlation between the number of IgE plasma cells in the tissues and IgE level in sera. Thus in air-borne conjunctival allergies local hypersensitivity seems to be the predominant, even exclusive, feature.

Adult↗
PubMed1977

[Hematological and clinical manifestations of bone marrow metastasis of carcinomas. Apropos of 36 cases verified by biopsy].

A retrospective study of 36 cases of bone marrow metastases from carcinoma is reported. In all cases, the presence of tumour cells was confirmed by needle biopsy of the bone marrow. The clinical picture was fairly typical: decline in general health, fever, bony pain and skin and mucosal hemorrhages. Radiological lesions of the skeleton were present in 64% of cases. Sometimes the blood disorders were isolated. Anemia was almost constant (86), normochromic, normocytic, and may be associated with leukocytosis and thrombopenia. Pancytopenia is rarer as also is a rise in the number of platelets. Erythremia, very suggestive, is demonstrated in 73% of the blood smears. In 31% of the slides examined again, schizocytes were found among the normal red cells. Disorders of hemostasis were easily circumscribed. As fibrinolysis was sometime found, hemostasis was studied as a routine in all patients. The special recruitment of a hematology unit explains the high frequency of blood abnormalities in this series of bone metastases.

Aged↗