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J Debray

Publications and source records attributed to J Debray.

At least 91 records · Page 5Linked to original sources
PubMed1979

[Hemolysis in Kala Azar: isotopic study, possible role of a PNH like defect (author's transl)].

A case of Kala Azar with prevailing hemolytic anemia is reported. The hemolysis has been associated during a short time with positive PNH test (i.e.: Crosby and sucrose tests). According to the data found in the Litterature, the hemolysis occurs quite frequently. One of the possible mechanisms is an abnormal sensitivity of the erythrocyte membrane to complement, which had not yet been described.

Adult↗
PubMed1978

[Study of caryotype in pre-leukaemic states (author's transl)].

Twenty-four patients, in a condition considered to be pre-leukaemic underwent study of marrow caryotype. Nine of them (37.5%) had an abnormal caryotype. The prevalence of abnormalities varied according to the type of pre-leukaemic state: 17% in acquired idiopathic sideroblastic anaemia, 33% in refractory anaemias with excessive myeloblasts, 100% in 3 cases of simple refractory anaemia. The abnormalities were non-systematised. However, in one case there was an abnormality already described in the literature and considered to be specific: deletion of the long branch of chromosome 5. In refractory anaemias with excess myeloblasts transformation to acute leukaemia appeared to be more frequent in patients with an abnormality (4/5) than in patients with a normal caryotype (0/10).

Aged↗
PubMed1978

Hairy cell leukemia: a clinical, immunological and ultrastructural study. New data for the origin of the hairy cell.

Seven patients presenting with the characteristic clinical and laboratory findings of HCL were investigated mainly in order to find the origin of the HC with histochemical, electron microscopic and immunologic techniques. The results we obtained are somewhat contradictory, as in the recent literature, if the HC's are to the considered as being exclusively of lymphocytic or monocytic origin. The data however indicate that HCL is not of one cell type but two. One of these cells has characteristics of a lymphocyte. The other one, an ill defined cell, has mixed characteristics of both the monocyte and lymphocyte series. This hairy cell may represent a new cell line.

Adult↗
PubMed1978

Acute eosinophilic leukemia. An ultrastructural study.

Observations on a 32 year old male are described. Hematological examination demonstrated leukocytosis with circulating blastosis and dystrophic hypereosinophilia of the blood and bone marrow, with cells at various stages of maturation. Cytotoxic chemotherapy led to complete remission for 5 months followed by a terminal relapse. No features in favor of an "eosinophilic collagenosis" were revealed at autopsy. Repetitive ultrastructural studies performed during evolution of the illness demonstrated considerable anomalies of the eosinophil line. The present observation thus shows the clinical, evolutional, cytological and autopsy criteria of an acute eosinophilic leukemia.

Adult↗
PubMed1978

[Merits of the assay of plasma catecholamines in a glucagon test to diagnosis of pheochromocytoma (author's transl)].

In one female patient suffering from an extra-adrenal pheochromocytoma, a stimulation test with glucagon was performed. In spite of the absence of an increase in heart rate and blood pressure, a pronounced increase in plasma catecholamines showed this test to be positive. The authors discuss the reliability criteria of this test, and confirm its good tolerance.

Adrenal Gland Neoplasms↗
PubMed1978

Abnormal lipoproteins in a case of primary biliary cirrhosis.

The serum of a patient diagnosed as a primary biliary cirrhosis was studied during the various evolutive stages of the disease. During the non-icteric period, the serum lipoprotein had the chemical composition (rich in cholesterol and phospholipids) of that found in cholestasis; however the bilirubinemia was normal, and no LPX was detected; there was a normal esterified to total cholesterol ratio and the alphaLP had not decreased, as expected, but increased and was divided into two fractions; immunoelectrophoretic studies of ultracentrifugal fractions showed some LP with HDL immunological properties, but with lower densities than that of normal HDL. We suggest that the phospholipid overloading of some of these HDL in the patient's serum could explain the changes in density. Some months after this study, the patient's serum exhibited the characteristics found in cholestasis, with disappearance of HDL and appearance of LPX. During the subsequent period, the serum again contained phospholipid rich HDL and LPX. In fact several LPX with different densities were found. It seems, therefore, that in cholestasis, LP undergo modification in which the HDL peptide chains play an important role.

Bilirubin↗
PubMed1978

[Cases of acute leukaemia following immunosuppressive therapy for disseminated sclerosis and for Behçet's syndrome (author's transl)].

On the basis of two personal cases of acute leukaemia occurring following immunosuppressive therapy for disseminated sclerosis and for Behçet's syndrome, the literature is reviewed. Thirty three similar detailed cases were collected. They are characterised in general by the prolonged use of immunosuppression. The acute leukaemia affected the granulocyte series in the majority of cases. In 30%; the leukaemia was preceded by a phase of several months of preleukaemic type dysmyelopoiesis. The mechanisms of action explaining this carcinogenic risk in a general way are multiple: the role of marrow aplasia, chromosomal abnormalities, the activation of a leukaemogenic virus, the role of immunodepression and that of repeated antigenic stimulation may all be discussed. The risks associated with such treatment should thus be borne in mind when evaluating its indications.

Behcet Syndrome↗
PubMed1977

[Acute granulous leukemia in multiple myeloma. Apropos of 5 cases].

The authors report five cases of acute granular leukemia which complicated the course of multiple myeloma treated by chemotherapy. They then review the literature, and discuss 30 cases which they found. The important point clinically is the long duration of the course (average 56 months) in multiple myeloma complicated by acute granular leukemia. Usually chemotherapy permitted a good quality remission and when the leukemia develops there is no longer any trace of myeloma. The mechanisms of onset of this type of leukemia during myeloma are discussed. They are probably complex and various but there is no doubt concerning the responsability of chemotherapy and in particular alkylating agents.

Adult↗
PubMed1977

[Inagural lymphoblatic transformation in chronic myeloid leukemia. Clinical and cytogenetic study of one case].

A fifty-year old patient was treated for acute lymphoblastic leukemia. One month after a complete remission, a syndrome suggesting chronic myeloid leukemia led the authors to study the marrow karyotype which revealed the existence of a Philadelphia chromosome. A second lymphoblastic attack occurred rapidly and a second complete remission was easily obtained. A few weeks later, occurred lymphoblastic meningitis. A new cytogenetic study then showed duplication of the Philadelphia chromosome. One may imagine that the initial attack represented acute lymphoid transformation of chronic myloid leukemia. The theoretical and practical significance of this case is discussed.

Bone Marrow↗
PubMed1977

[Changes in the level of various amino acids in leukemia].

The determination of blood amino-acids by column chromatography has been carried out on 53 patients, 17 with acute myeloid leukemia, 22 with chronic myeloid leukemia. A comparison was made with 25 normal subjects. These determination has shown a significant increase in glycin, cystin and a non significant increase of tryptophan. A positive relationship may exist between uricemia and content of glycin and glutamin, both amino-acids which are messengers of uric acid. A positive correlation has been found between glycin tryptophan and the number of myeloblasts.

Amino Acids↗