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Biomedical subjects

J Debray

Publications and source records attributed to J Debray.

At least 109 records · Page 6Linked to original sources
PubMed1977

[Systemic mastocytosis with myeloid splenomegaly type hematological manifestations].

The authors report the case of a patient suffering from systemic mastocytosis with cutaneous, medullary, bone, hepatic and splenic involvement, the clinical and haematological picture of which was that of myeloid splenomegaly. Furthermore, this picture included hypersplenism, clearly demonstrated by isotopic study and the successful results of splenectomy. Blood histamine levels were normal though urinary excretion of histamine was increased. Histamine levels in the spleen were greatly increased. Serotonin levels in the blood and its urinary metabolites were normal. Heparin activity was demonstrated in the spleen, but not in the blood.

Biopsy↗
PubMed1977

[Human erythrocyte glycerides].

There are difficulties in measuring red cell glycerides mainly because the amount found in erythrocytes is so differne from that of other lipids in blood cells. The red corpuscles contain only very small quantities of glycerides, about 5mg/1, while the amount of cholesterol and phospholipids is 200 to 500 times higher. The methods currently used for estimating glycerides in serum can be used here only after removing these other lipids. The distribution of glycerides in erythrocytes is ver different from that of serum: serum contains mainly triglycerides while there are diglycerides as well as triglycerides in erythrocytes (on average 3,4 micro mol/1 of triglycerides and 1,7 mumol/1 of diglycerides).

Cholesterol↗
PubMed1977

[Monoclonal paraproteins other than in Kahler's and Waldenström's diseases. Apropos of 67 cases].

On the basis of 67 cases of patients suffering from monoclonal dysglobulinaemias other than multiple myeoloma and Waldenström's disease, the authors report the characteristics of their series. The review current diagnostic criteria and, in this context, present their experience of caryotypic determination which was carried out in 24 subjects. These dysglobulinaemias may occur in isolation, on a familial basis or in association with some other pathology, which leads to the suggestion of a number of aetiopathogenic hypotheses, which are probably interlinked.

Adult↗
PubMed1976

[Myelomatous G-kappa immunoglobulin with antistreptolysin O activity].

A new case of myeloma with antistreptolysin O activity is described. The myeloma protein is Kappa IgG. By precipitation of this myeloma IgG with anti-Kappa antiserum, the antistreptolysin O activity is completely inhibited. For the antibody activities of the myeloma protein described in the litterature, the antistreptolysin O activity is the most frequently found. With this 19th case the authors discuss the fundamental problems of the antibody activities of myeloma protein.

Antibody Specificity↗
PubMed1976

[Epileptic seizure revealing a cerebral arterial accident during administration of oral contraceptives with platelet function disorders].

The authors observed the onset of an epileptic fit in a 27 year-old woman, ten months after starting treatment with the contraceptive pill. Carotid arteriography revealed the existence of non-obstructive lesions in the area supplied by the left anterior cerebral artery. Disorders of platelet aggregation and disaggregation were demonstrated 15 days after stopping the contraceptive treatment. The significance of these abnormalities is discussed in the light of data in the literature.

Adult↗
PubMed1976

[Spontaneous septic arthritis in disseminated lupus erythematosus].

The authors report the case of a young 17 year-old girl with acute systemic lupus erythematosus who presented with purulent arthritis due to Group A hemolytic streptococcus in the knee, and perhaps other joints. She had not yet received any treatment. The purulent arthritis was cured by antibiotics. In spite of corticosteroids and immuno-suppressive agents (Chlorambucil), the patient died one year later. Spontaneous purulent arthritis is rare during systemic lupus erythematosus. We found only 8 other cases in the world literature. Contrary to our case, these were patients already treated with corticosteroid or immuno-suppressive agents. In our patient, the absence of previous treatment permitted us to incriminate the lupus itself in the onset of this infection. The conditions of onset of infection during lupus erythematosus are discussed.

Adolescent↗
PubMed1976

[Circulatory disorders induced by amantidine].

Amantadine has been used since 1969 in the treatment of Parkinson's disease. In 1970, were described the special symptoms noted in the lower limbs due to this drug. The authors, after a review of the various disturbances, have studied 10 cases by Capillaroscopy. They emphasize the interest of the study of this abnormality of the micro-circulation, producing vaso-constriction of the arterioles and venules.

Aged↗
PubMed1976

[Mixed hyperlipoproteinemias. Importance of diet].

The interest of diet is particularly clear in mixed hyperlipemia. In fact, the authors were only able to define the type of lipid abnormality after a test diet and prolonged supervision. One should never treat mixed hyperlipemia straightaway with hypocholesterolemic agents. The authors studied 22 patients with a form only demonstrable in the laboratory. There were no clinical signs of arteriosclerosis. In the group of dyslipemic subjects with minor hyperlipemia, they obtained normal figures for serum cholesterol and triglyceride. The results remained stable after 4 months supervision.

Adult↗
PubMed1975

[Determination of the microcirculatory blood flow by pulp plethysmography].

A method for clinical determination of blood inflow at the tip of digit, using mercury strain gauge plethysmography with venous occlusion, is presented, including a satisfactory way of calibration of the "closed type" gauges. Theoretical considerations and experimental data allow to consider the accuracy of the method (of +/- 7 p.cent) to be of clinical value.

Fingers↗