Search PubMed⌕ Search

Biomedical subjects

J Debray

Publications and source records attributed to J Debray.

At least 73 records · Page 4Linked to original sources
PubMed1982

[Radiation-induced coronary artery disease. One observation (author's transl)].

Twenty-seven reports (26 from the literature) of radiation ischemic heart diseases are studied in order to specify their clinical and pathological findings and their natural history. This complications appear after treatment of radiation-curable diseases with a mean delay of 4 years in young patients (mean age of 31). Several coronary arteries are often injured with fibrous and or atherosclerotic anatomical lesions. The frequency of this coronary artery diseases is certainly more important than reported since they are often latent but probably progressive. However, atherogenic factors increase the risk and must be lowered in a preventive aim; as a rule, the radiotherapeutic technique must also be as perfect as possible. The prognosis of this radiation induced coronary artery diseases is poor: 19 myocardial infarctions and 12 deaths are observed but no cardiac death occurred in patients who received a by-pass graft. So, radiation ischemic heart disease needs active investigation and therapy.

Adult↗
PubMed1981

Post-heparin lipolytic activity with no hepatic triacylglycerol lipase involved in a mammalian species.

It was found that lipolytic activity in bovine post-heparin plasma differed from that of other mammalian species by the fact that intravenous heparin induced the release of lipoprotein lipase but not hepatic triacylglycerol lipase. Initially, this fact was strongly suspected when no remaining lipolytic activity could be found after whole bovine post-heparin plasma had been tested with either 1 M NaCl or antiserum against lipoprotein lipase. This was further confirmed by using heparin-Sepharose affinity chromatography when the entire lipolytic activity was eluted with 1.5 M NaCl but none with 0.4 or 0.7 M NaCl. The active fraction had lipoprotein lipase characteristics, i.e. it required serum activators to produce optimum activity and was fully inhibited by NaCl of high molarity and by anti-lipoprotein lipase antiserum. Neither the different doses of heparin nor the various times of sampling altered the results. This raises the question whether hepatic triacylglycerol lipase is absent from the bovine liver or whether this enzyme is present but cannot be released by heparin.

Animals↗
PubMed1981

[Initial bone marrow involvement in Hodgkin's disease (author's transl)].

Twenty-five patients with Hodgkin's disease and evidence of bone marrow involvement (BM +) were compared with 25 other Hodgkin patients, chosen at random, who had visceral lesions but free bone marrow (BM -). Both groups were observed throughout the same period. The first evaluation showed that bone marrow involvement was more frequent in male patients and that it produced medullary hypoplasia with WBC and platelet counts lower than in BM - patients. However, bone marrow involvement can only be ascertained by medullar biopsy. BM + patients were treated with multiple chemotherapy (mostly MOPP). Positive response was obtained in 64% and complete remission in 50%, as compared with 70% and 50% respectively in BM - patients. There was no significant difference in overall survival rate between the two groups. It remained in plateau at 50.5% after two years in BM + patients and at 63% after 27 months in BM - patients. When complete remission was obtained the survival rate after one year was 90% for BM + patients and 100% for BM - patients. In the absence of complete remission, however, the median survival time was inferior to one year in both groups. The dosage levels and side-effects of chemotherapeutic agents were similar in both groups, but cytopenia was more pronounced in BM + patients.

Adult↗
PubMed1981

[Two cases of agnogenic myeloid metaplasia associated with chronic lymphocytic leukemia (author's transl)].

Two cases of agnogenic myeloid metaplasia associated with chronic lymphocytic leukemia are reported. Both cases are documented by clinic, bone marrow biopsy, immunologic and isotopic studies. Such observations allow to point out the lymphoproliferative pattern that can be found among any agnogenic myeloid metaplasia. It is suggested that this disease includes a monoclonal lymphoid proliferation which may become the prevailing symptom.

Aged↗
PubMed1980

[Primary biliary cirrhosis associated with acute disseminated lupus erythematosus (author's transl)].

A 39 years old man experienced typical primary biliary (P.B.C.). Additional symptoms occured during the next four years including constitutional symptoms, polyarthralgias, nephrotic syndrom and chronic polyarthritis. Biologically, at the beginning of the disease, antimitochondrial antibodies were at the titer of 1/50,000, and the antinuclear antibodies at the titer of 1/10,000 (speckled pattern). During the course of the disease antimitochondrial antibodies decreased progressively and disappeared at the last control. The antinuclear antibodies progressed until 1/500,000 with anti Sm specificity. The association of P.B.C. and S.L.E., very seldom mentioned in the literature, is discussed among the auto-immune diseases.

Acute Disease↗
PubMed1980

[Beta blockers and disturbances of the microcirculation (author's transl)].

Study of 192 cases of hypertensive patients, 89 of whom were treated by diet, general advice and correction of risk factors for an average period of 8 months. The group of patients treated beta blockers consisted of 103 subjects, 28 of whom received Propranolol, 29 Oxyprenolol, 20 Atenolol and 26 Practolol. The prevalence of Raynaud's phenomenon was markedly greater in the patients treated with beta blockers, in comparison with the group not receiving any drugs. The highest incidence of vasomotor problems was seen in the group of subjects treated with Propranolol, with 57% of patients having a Raynaud-type paroxysmal acrosyndrome. In more than half of the cases attributed to Propranolol, the clinical picture of Raynaud's syndrome was severe. Discussion of the mode of action of beta blockers on the microcirculation.

Adrenergic beta-Antagonists↗
PubMed1980

Purification of an anti-lipoprotein lipase antiserum.

Lipoprotein lipase is an enzyme difficult to isolate in pure form and, until now, the antisera prepared against it have not been monospecific. The present experiments show how a crude antiserum prepared with bovine milk lipoprotein lipase, can be made more specific through suitable adsorption. The crude antiserum was prepared by injecting milk lipoprotein lipase prepared by heparin Sepharose affinity chromatography. Immunodiffusion techniques indicated that the antiserum contained antibodies to proteins other than lipoprotein lipase (bovine milk and serum proteins) and that these antibodies could be eliminated by adsorption with bovine serum and a beta-casein preparation.

Adsorption↗
PubMed1980

[Lipoprotein lipase. Interest in clinical biochemistry (author's transl)].

Lipoprotein lipase (LPL) is an enzyme which hydrolyses triglycerides especially VLDL and chylomicrons triglycerides. The measurement of LPL can be of interest in clinical biochemistry. There is no LPL in blood circulation, but it is possible to release it by heparin intravenous injection. However, heparin releases also other enzymes, particularly hepatic triglyceride lipase (HTGL). It is then post-heparin lipolytic activity (PHLA) which is determined. It is possible to measure separately LPL and HTGL, by using antibodies or inhibitors so chosen to be specific to one or the other enzyme. The main variations of LPL and HTGL in various diseases or treatments at present known are reported. LPL has also been recently involved in atherosclerosis pathogeny.

Adipose Tissue↗
PubMed1979

[Raynaud's syndrome: study of fingertip blood flow by plethysmography with venous occlusion (author's transl)].

The fingertip blood flow was measured by venous occlusion plethysmography in a room at 22 degrees C, in 52 patients with Raynaud's syndrome and 24 healthy controls. In severe Raynaud's syndroms (24 cases incuding: scleroderma: 7 cases, thromboangitis: 5 cases, disabling syndrom without known etiology: 12 cases), the flow was significantly lower than in moderate Raynaud's syndroms (19 cases including 10 primary and 9 secondary syndroms) i.d. 7.5 +/- 7.3 ml versus 25 +/- 15 ml (p < 0.001). Controls had significantly higher flow (35 +/- 12.3 ml) than moderate Raynaud's syndroms (p < 0.05). Raynaud's syndroms with permanent acrocyanosis had a low flow (8.7 +/- 5.3 ml) not different from severe syndroms.

Adolescent↗
PubMed1979

[Yersinia pseudotuberculosis septicemia in adults (author's transl)].

The authors discuss the clinical and bacterial characteristics and progressive changes occurring in Yersinia pseudotuberculosis septicemia, basing their observations on one personal case and 30 adult cases reported in the published literature. The roles played by a generally poor condition of the patient and martial overloading are emphasized, and the changes brought about by the introduction of antibiotic therapy evaluated.

Adult↗
PubMed1979

[Zollinger-Ellison syndrome with high blood calcium levels resembling the neoplastic type (author's transl)].

A patient with the Zollinger-Ellison syndrome was found to have increased blood gastrin levels associated with the secretion of a compound which produced high blood calcium levels. This compound differed from immunoreactive parathormone, and caused the clinical picture of primary neoplastic hyperparathyroidism. This case is compared with other cases of multiple-secreting Zollinger-Ellison syndrome reported in the published literature, within the framework of the "A.P.U.D." system.

Aged↗