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Biomedical subjects

J D Ringe

Publications and source records attributed to J D Ringe.

At least 109 records · Page 6Linked to original sources
PubMed1983

[Clinical significance of direct measurement of bone mineral content. 125I photon absorption measurement in 1252 cases].

1252 patients were examined by 125I-photonabsorptiometry, a non-invasive method for direct determination of bone mineral content. These patients were divided into 21 groups with different diagnoses including primary skeletal disorders and diseases of internal medicine (endocrine, gastrointestinal, renal) with possible secondary skeletal involvement. The findings are analyzed on the basis of well established own normal ranges, which were obtained from determinations on 1058 healthy people. The well reproducible and quantitative results allow to cover the frequency and severity of deficits in bone mineral mass occurring with the diseases mentioned above. As examples the findings in primary hyperparathyroidism and in chronic renal insufficiency before and during hemodialysis are shown in more detail. While the radiation exposure is practically negligible, control measurements can be performed regularly, which supply a good judgement of the course of disease with and without treatment.

Adolescent↗
PubMed1981

[Treatment of Paget's disease of bone with salmon calcitonin (author's transl)].

Subcutaneous injections for two days of 100 MRC units each of synthetic salmon calcitonin were administered to 40 out of 77 patients with Paget's disease of bone. Chemical pathology (alkaline serum phosphatase, hydroxyprolinuria) showed an initially satisfactory response of all patients to this treatment. Resistance developed in 6 out of 8 patients on long term treatment with recurrence of increased serum alkaline phosphatase, occurring after 4 months at the earliest and 24 months at the latest. Human calcitonin may be an alternative of treatment in these cases of secondary resistance. Treatment with calcitonin is nearly risk-free and represents a definite progress in comparison with earlier forms of treatment.

Aged↗
PubMed1981

[Calcium and bone metabolism after jejunal bypass operation for alimentary obesity: model for a intestinally-conditioned disorder (author's transl)].

Jejuno-ileostomy was performed in eight women because of severe alimentary obesity. Their calcium phosphate and bone metabolism was studied an average of 31 months post-operatively. This revealed secondary intestinal hyperparathyroidism due to an artificial malabsorption syndrome. While most of the significant metabolic factors were within normal limits, examination of calcium balance and kinetics indicated a marked disorder of calcium and bone metabolism. Calcium balance averaged-138 mg daily, corresponding to a yearly loss of skeletal mass of 4-5%.

Adolescent↗
PubMed1981

[The influence of cyclophosphamide upon the healing of fractures in the rabbit (author's transl)].

The influence of cyclophosphamide (Ctx) upon the healing of fractures in the femur of the rabbit is reported. During treatment with Ctx the x-ray shows a reduced callus-formation; the fluorescence-microscopy reveals a decreased apposition of bone. Fracture-load, fracture-energy and mineral content of the intact bone are not influenced by Ctx. Four weeks after an operation fracture-load and fracture-energy are reduced almost by one half and the mineral content is decreased significantly.

Animals↗
PubMed1980

[Diagnostic value of selective parathormone determination in primary hyperparathyroidism].

The preoperative localisation of parathyroid adenomas is difficult even for an experienced surgeon. The rate of unsuccessful exploration of the neck lies between 2 and 18%. This is mainly due to to anomalies and extremely small adenomas. In vivo staining with toulidine blue, isotopic labelled selenmethionin or angiographic localisation are uncertain procedures. More accurate results can be achieved through fractionized measurement of parathyroid hormone with selective venous catheterization. This method was applied in 47 out of 71 patients with a correct localisation being achieved in 77%. In connection with subtle laboratory diagnosis and repeated assessment of serum calcium and phosphorus, this procedure is the method of choice. In cases with normocalcaemia surgical indication should be considered with due reservation despite positive localisation.

Adenoma↗
PubMed1979

[Paget's osteodystrophia deformans. Occurrence, clinical aspects and complications].

33 monostotic and 27 polyostotic manifestations were found in 60 patients with Paget's disease of bone, 30 of whom were females (mean age 65.7 years) and 30 males (mean age 62.8 years). Pelvis, right tibia, lumbar spine, skull and sacrum were most commonly affected. Alkaline phosphatase activity in serum was raised in 95%, and in 88% hydroxyproline excretion in urine was increased. Due to the variable primary osseous or secondary arthrogenic complaints four groups could be distinguished among the monostotic cases. In polyostotic forms only some of the affected bones caused symptoms, whereas the other locations were only detected radiographically. The indication for calcitonin treatment of Paget's disease can only be made after in-patient investigation and evaluation of skeletal involvement, activity of the disease, complaints and assessment of complications actually present or to be expected according to the pattern of involvement. Under these conditions this form of treatment appeared indicated in 41 of 60 patients.

Adult↗
PubMed1979

[Paget's disease--manifestations in the vertebral colum. Computer tomographic investigations (author's transl)].

Computer tomography has been found to be of value in the study of deformities and narrowing of the spinal canal in 52 patients with Paget's disease of vertebral bodies. To a limited extent it can also be used for evaluating the intervertebral foramina. Deformities of the spinal canal were classified into three degrees of severity. The most severe changes were found in the lower thoracic region. The presence of neurological complications is an indication for CT studies.

Aged↗
PubMed1979

[X-ray morphology of osteodystrophia deformans Paget (author's transl)].

Osteodystrophia deformans Paget is a frequent and localised disease of the skeleton in elderly persons. The x-ray morphology of the disease is not uniform. It depends on the site at the skeleton, on the design of the affected bone, and on the stage and course of the disease. Basing on 71 own observations, the various types of manifestation are discussed and both their characteristic and non-typical pattern explained. Attention is drawn to the complications which can result from involvement of the individual parts of the skeleton.

Aged↗
PubMed1978

[Results of long-term treatment of primary osteoporosis with sodium fluoride (author's transl)].

Twenty-three patients with primary osteoporosis were treated with sodium fluoride over 25 months. Mean total dose was 21 g fluoride. Symptoms, body size, biochemical results, radiological changes and skeletal mineral content as well as bone histomorphometry were evaluated in assessing results of treatment. Accordingly, no advance in the disease process was demonstrable in 13 patients, while there was definite improvement in six, but in four there was further progression.

Body Height↗
PubMed1978

[Bone mineral content during chronic hemodialysis long term observation by 125-i photonabsorptiometry (author's transl)].

40 out of 98 patients on chronic haemodialysis show an obviously lowered bone mineral content of the radius (mean -20.4%), 51 patients attain values in the normal range (mean -1%) and 7 subjects slightly increased values (mean +10.9%). A bone mineral loss of 2.5% could be found after long-term observations of this parameter between 6 to 30 months (mean observation period: 15 months). In general a progressive loss of the bone mineral content may be noticed with an increased duration of haemodialysis. This tendency is more distinct after the 40th year of life because of the simultaneous age-depending physiological decrease of bone mass. Abruptly occurring mineral losses of the skeleton may be due to a high incretion of parathyroid hormone and possibly require subtotal parathyroidectomy.

Adolescent↗