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Biomedical subjects

J D Ringe

Publications and source records attributed to J D Ringe.

At least 127 records · Page 7Linked to original sources
PubMed1978

[The value of visual judgements of the calcium content of the skeleton (author's transl)].

The mineral content in 113 forearm bones were evaluated visually and compared with the results of measurements of the cortex and of iodine 125 photon absorption measurements. There was a significant correlation between measurements of cortical width and direct measurements of mineral content. In general, visual grading into four groups was reasonably accurate, but in individual cases there were considerable errors. Of 11 cases with a mineral loss of more than 30%, only one was regarded as normal. A particular difficulty in the visual evaluation was the great physiological variation of mineral content related to age and sex; this must be taken into account.

Adult↗
PubMed1978

[The coincidence of Paget's disease and an immunoblastic sarcoma (author's transl)].

Malignant change is to be expected in about 1% of patients with Paget's disease. Usually these are osteosarcomas. Fibrosarcomas, benign and malignant giant cell tumours and chondrosarcomas are less common. The present case concerns the development of an immunoblastic sarcoma in the humerus, which was affected by Paget's disease. Only one other similar case is recorded in the literature. Other myelogenous tumours, such as plasmocytomas, are very rare in association with Paget's disease. Consequently there is no evidence for a causal connection between Paget's disease to these tumours, whereas sarcomas arising from bine tissue may be regarded as a form of malignant degeneration of Paget's disease.

Bone Marrow Diseases↗
PubMed1978

[Physiological increase in the mineral content of the radius and ulna during growth (author's transl)].

Bone mineral estimations were carried out in 273 normal youngsters aged 6 to 18 years using a 125I photon absorption technique. Measurements were carried out at two points on the radius and ulna. Normal values for different ages were calculated for both sexes. Statistical analysis of the data, together with measurements obtained from 773 adults, has shown that the curve derived from children and adolescents merges smoothly with that for adults.

Adolescent↗
PubMed1977

[Paget's disease of bone: ultrastructure and cytogenesis of osteoclasts (author's transl)].

The cytogenesis of giant osteoclasts in Paget's disease of bone was studied by means of electron microscopy. 26 iliac crest biopsies were made and divided for light and electron microscopic investigation. A special procedure was used for electron microscopic preparation of bone without previous decalcification. Paget osteoclasts are characterized by their high content of nuclei. Several nuclei may show paracrystalline inclusions pointing to a possible virus infection of these cells. Giant osteoclasts have an increased mobility and a high resorptive activity, manifest by the dissection of bone fragments from endosteal bone surfaces. Cell membrane interdigitations between mononuclear cells and osteoclasts occur as a morphologic concomitant of cell fusion. Frequent occurence of such cell membrane contacts seem to indicate an increased tendency to cell fusion among the mononuclear precursors of Paget-osteoclasts. Precursor cells are located in the pericapillary region, and morphologically resemble pericytes. The assumption of an increased rate of cell fusion amoungst the precursor cells of osteoclasts might explain the development of giant osteoclasts in this disease. Further studies of the paracrystalline nuclear inclusions of Paget-osteoclasts are necessary to determine whether this process can be considered to be a cytopathogenic effect of virus infection.

Aged↗
PubMed1977

[False diagnosis of "osteoporosis" in diffuse multiple myeloma (author's transl)].

Multiple myeloma is very frequently diagnosed too late. In ten patients in whom the diagnosis was ultimately made in the course of one year, the early symptom of back or skeletal pain was at first most frequently misdiagnosed as osteoporosis and so treated. Such symptoms as loss of weight, increased sedimentation rate and increase in gamma-globulins should have led to further tests, for example sternal puncture, radiological survey of the entire skeleton, and immuno-electrophoresis.

Aged↗
PubMed1976

[Mineral content of bone in long-standing diabetes: densitometry of "diabetic osteopathy" (author's transl)].

Using 125I-photon absorption, skeletal mineral content was measured in 57 diabetics requiring insulin. Average age was 33 years, mean duration of diabetes 19 years. Abnormally reduced mineral content was detected in ten of 21 males and 11 of 36 women. This finding is interpreted as being a late complication of diabetes. Pathological fractures were not seen and there were very few complaints referable to the skeletal system.

Adolescent↗
PubMedDate not supplied

Changes in heart rate by verapamil during carotid sinus stimulation in patients with hyperparathyroidism, pre- and postoperatively.

It has been investigated whether calcium- and verapamil-dependent sensitivities of carotis baroreceptors also exist in man. To answer this question, we pre- and postoperatively measured changes in heart rate during carotid sinus stimulation before and after intravenous administration of 5 mg verapamil in 23 patients with primary hyperparathyroidism. Findings during hypercalcemia were as expected: a more pronounced reduction of heart rate at comparatively low calcium levels. During normocalcemia, we found an opposite effect: a more pronounced reduction at relatively high calcium levels, which was statistically significant. This fact could be explained according to our interpretation. In previous reports, local effects on baroreceptors were examined, whereas we measured the combined effect of several calcium actions. As expected, verapamil attenuated the decrease in heart rate which, however, was not statistically significant.

Calcium↗
PubMedDate not supplied

The interpretation of preclinical data in predicting bisphosphonate response in the treatment of osteoporosis.

Individual bisphosphonates for the treatment of osteoporosis are often compared on the basis of preclinical variables such as potency, selectivity, therapeutic index, and effects on fracture healing. The present review examines the methodology and results of preclinical studies providing these types of data for the bisphosphonate etidronate and compares them with the available preclinical data for other bisphosphonates. Analysis of the preclinical data in relation to the results of long-term clinical trials reveals that widely reported differences in preclinical variables for the different bisphosphonates are not significant once dosages and treatment regimens have been optimized for therapeutic use in the clinic.

Animals↗
PubMedDate not supplied

[Disabling senile osteoporosis].

Fractures of the proximal femur are the most dangerous complications of type-II-osteoporosis with a high rate of disability and mortality. In contrast to type-I-osteoporosis, men are affected rather frequently (ratio 1:3). We report on a 79-year old man who was completely in need of care after bilateral fractures of the humerus after having survived a previous pertrochanteric fracture of the left femur. Diagnostic procedures revealed that in this case an intestinal malabsorption has to be taken into consideration as a pathogenetic factor of this severe osteopathy. Bone biopsy confirmed a combination of osteoporosis and osteomalacia. Partial gastrectomy, which had been performed 10 years before, was obviously the reason for malabsorption having caused furthermore pernicious anemia, severe malnutrition and exsiccosis.

Aged↗
PubMedDate not supplied

[Diagnostic procedure in osteoporosis].

Osteoporosis is a very important differential diagnosis in chronic back pain. Early diagnosis of osteoporosis remains difficult, as an initial loss of skeletal mass cannot be recognized in X-ray pictures. A clear assessment can only be reached by the application of different non-invasive quantitative methods of bone mineral determination. So far as possible bone mineral content should be measured at an axial and a peripheral site of the skeleton. Crush fractures of vertebrae indicate an advanced calcipenic osteopathy. During the diagnostic procedure of osteoporosis other metabolic osteopathies (e.g. the different forms of hyperparathyroidism and osteomalacia) must be excluded by laboratory examinations or sometimes even by bone histology. If other generalised osteopathies can be excluded one has to look for etiological factors of a possible form of secondary osteoporosis because some of these allow a specific therapeutic approach. In about 80% no disturbances of calciumphosphorous metabolism can be detected, which means that a diagnosis of primary (idiopathic) osteoporosis must be made. In primary and secondary forms of osteoporosis the actual skeletal status and the activity of the osteoporotic process should be defined before beginning a differentiated treatment.

Back Pain↗
PubMedDate not supplied

[Senile osteoporosis--prevention and therapy].

Senile osteoporosis (type II-osteoporosis) is the final result of a large number of risk factors and negative effects on bone tissue which affect the skeleton throughout life. Important phases include bone formation during childhood and adolescence, the following obligatory loss of bone substance in the process of bone remodeling, periods of increased bone loss due to individual risk factors and augmented bone resorption in advanced age. According to this complex pathogenesis affecting the skeleton throughout life prevention is a lifelong task. The most important measures include a high calcium diet, regular physical activity, avoidance of risk factors and in postmenopausal women long-term sequential estrogen-progesteron substitution. The primary goal of therapy of established osteoporosis in the elderly is to relief symptoms and pain. Further treatment with the aim to keep or even increase bone mass (e.g. calcitonin, fluoride, calcium) may be indicated in individual patients taking into consideration age, disease activity and other individual prognostic factors.

Aged↗