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Biomedical subjects

J D Ringe

Publications and source records attributed to J D Ringe.

At least 91 records · Page 5Linked to original sources
PubMed1987

[Non-tropical sprue, a frequently unrecognized cause of high-grade generalized osteopathy].

Average interval from initial symptoms to diagnosis in 47 patients with non-tropical sprue was 8.3 years. Predominantly skeletal symptoms without typical gastro-intestinal symptoms occurred in about one third of cases, probably a reason for the delay in diagnosis. In more than 90% of cases there was the histological picture of osteopathy, osteomalacia with or without secondary hyperparathyroidism being about twice as frequent than osteoporosis. Biochemical and histological findings correlated well. In more than 80% of cases the mean mineral content of the radius bone was reduced by more than 30% of normal, while radiological findings were abnormal in only just half the cases. Even in the absence of diarrhoea, non-tropical sprue should be considered in aetiologically uncertain cases of generalised osteopathy.

Adolescent↗
PubMed1987

Salmon calcitonin in the therapy of corticoid-induced osteoporosis.

There is uncertainty about the best treatment for steroid-induced osteoporosis. Thirty-six patients with steroid-dependent, chronic obstructive lung disease and associated steroid osteoporosis have been studied, of whom 18 were treated with salmon calcitonin and the other 18 served as controls. Treatment lasted for 6 months and consisted of 100 I.U.s.c. every other day. In the controls there were significant decrements of 1.4% and 3.5%, respectively, in cortical and cortical and trabecular bone mineral content, whereas in subjects on calcitonin there were increments of 2.6% and 2.7%, respectively. Additional evidence of positive effect of calcitonin was derived from the reduced incidence of new fractures occurring during the observation period. A significant reduction in back pain was a further consequence of the hormone therapy.

Adrenal Cortex Hormones↗
PubMed1985

[Unusual course of renal osteopathy with Paget's disease and aluminum deposits].

In a woman with chronic renal failure due to interstitial nephritis after chronic analgesic abuse, secondary hyperparathyroidism was at first the predominant feature during a one-year period of dialysis. After parathyroidectomy severe aluminium-induced osteomalacia dominated the picture in the final phase. Surprisingly hyperparathyroidism recurred despite removal of all glandular tissue, and there also developed--previously undescribed--Paget's disease.

Aluminum↗
PubMed1985

Increasing skeletal involution in the elderly?

Studies of bone mineral content (MC) of the limbs in normal populations have shown there is an increase of MC during adolescence, a maximum MC for both sexes between 30 and 40 years of age and a subsequent decrease which is at least twice as great in females than in males. There are different findings in the literature on the course of these MC changes with aging. The present cross-sectional study of 180 subjects over age 70 showed a slight increase in the annual decrease of radius MC in females and a distinct acceleration of the MC decrease in males after about 80 years. This occurred for both a pure cortical measuring site of the radius (1/3-site) and for a mixed cancellous/compact site of the distal radius (1/10-site). These findings differ from those in other populations.

Adolescent↗
PubMed1984

Reversible hypertension in primary hyperparathyroidism--pre- and posteroperative blood pressure in 75 cases.

In 75 operatively proved cases of primary hyperparathyroidism (PH) mean systolic and diastolic blood pressure (BP) values were significantly higher pre- than postoperatively. There were 27 patients (36%) who showed hypertension before operation (systolic BP greater than or equal to 150 mm Hg, mean 169 +/- 20 mm Hg). In 20 of these the hypertension was reversible after successful treatment of PH, in seven cases elevated values persisted. The mean age of patients with persisting hypertension was significantly higher than the group with normalization of BP after operation (P less than 0.01). As far as clinical presentation of PH was concerned it were those cases with hypercalcaemic syndrome and with accidentally discovered hypercalcaemia who most often showed hypertension. In cases with recurrent urolithiasis and with osteitis fibrosa as leading symptoms there was no significant increase of hypertension as compared to the whole group. Because of the relatively high incidence of hypertension in PH this possibility should be taken into consideration in each diagnostic clarification of hypertensive patients.

Aged↗
PubMed1984

Frontometaphyseal dysplasia: symptoms and possible mode of inheritance.

Frontometaphyseal dysplasia is a rare syndrome of which only 20 cases have been described thus far. In this paper we report a 46-year-old man who showed a medium degree of manifestation of the disorder. The variable expressivity in both sexes, as derived from the careful study of reported symptoms in all known cases, was discussed. On the basis of the published pedigrees and additional information from our case, the possible mode of inheritance was debated.

Bone Diseases, Developmental↗
PubMed1984

[Quasi-distribution-free multivariate assessment of clinico-chemical patient data using of van der Waerden's X-transformation].

A reference group (252 males, 436 females) and a group of patients with primary hyperparathyroidism (34 males, 67 females) and cirrhosis of the liver (33 males) were subjected to a multivariate data assessment; the analyses were performed on the Technicon autoanalyzer SMA 12/60 (sodium, potassium, chloride, total protein, albumin, inorganic phosphorus, cholesterol, urea nitrogen, calcium, creatinine, bilirubin, uric acid) and the SMA 6 plus (iron, copper, magnesium, alkaline phosphatase, acid phosphatase, glucose). A multivariate test statistic containing age as a regressor variable was used, thus correcting for age. Derivation of the test statistic required multivariate normality of the distributions of the clinical-chemical values, a condition which is generally not fulfilled in the data of patients. In order to arrive at the multivariate normality of the distributions, we applied the X-transformation of van der Waerden [1965) Mathematische Statistik, Springer Verlag, Berlin--Göttingen-Heidelberg) to the marginal values. We introduced the concept of group-conformity behaviour of the patient data. According to our definition, a patient behaves in conformity with a given group of patients with respect to a clinical-chemical value, if the patients' value deviates from the estimated age-specific expected value of the reference group and the deviation lies in the same direction as that of the mean value of the respective group of patients. Using this procedure, disease-specific deviation patterns were determined from the data, thus enabling us to make clear separations of the patient groups from the reference group and from each other. Furthermore, the computed deviation patterns throw light upon the pathobiochemical modifications of the parameters in the examined diseases.

Acid Phosphatase↗
PubMed1983

[Staphylococcal spondylitis--cause of a recurrent fever for 24 years].

A 72-year-old man had had recurrent fever of undetermined cause, for which he had repeated periods in hospital. There were no specific organ-related symptoms. Conventional radiology of the vertebrae, tomography, CT scan and CT-guided needle biopsy finally revealed the presence of staphylococcal spondylitis of thoracic vertebrae 11 and 12 with bilateral paravertebral abscesses. Particularly valuable diagnostically was the CT scan with demonstration of bony destruction in the axial plane and of the paravertebral soft-tissue changes, as well as the use of CT-assisted puncture of the abscess. Asymptomatic spondylitis should be thought of as a possible cause of pyrexia of unknown origin.

Aged↗
PubMed1983

[Preoperative localization diagnosis of parathyroid adenomas in 72 cases of primary hyperparathyroidism by selective catheterization of neck veins and parathyroid hormone determination].

In 72 cases of primary hyperparathyroidism, selective venous catheterization was performed preoperatively to localize parathyroid adenomas. Diagnosis of primary hyperparathyroidism was proved by operation in all but 5 cases, in which no adenomas could be found intraoperatively. By venous catheterization of the neck and upper region of the thorax, an average of 10 blood samples per patient were taken. Parathyroid hormone was estimated by radioimmunoassay with high sensitivity against the intact PTH-molecule and carboxy-terminal fragments. Only in 24 out of 72 cases was localization of parathyroid adenomas prognosticated correctly with respect to side and height, while in a total of 38 cases localization on the right or left side only could be determined preoperatively. These unsatisfactory results can be improved only by a much more extensive catheterization technic which would be justified only in patients already operated on before without success. The final evaluation of non-invasive methods, e.g. ultrasonics and computerized tomography, is still under discussion.

Adenoma↗