The interpretation of thallium-201 cardiac scintigrams. Studies in experimental ischemic heart disease in dogs.
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Biomedical subjects
Publications and source records attributed to J Clark.
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Measurement of the dynamic pulmonary compliance was carried out on 27 normal dogs weighing 11-8 to 26-4 kg Variations in the results of repeated observations and difficulties in allowing for differences in lung size between dogs limited the usefulness of the measurement as a test of lung function. Pulmonary compliance was found to correlate better with trunk length than with bodyweight or chest circumference. The mean value for dynamic pulmonary compliance measured during inspiration in 27 normal dogs was 0-117 litre/cmH20 with a standard deviation of 0-046 litre/cmH2O. Measurements were made on six dogs with clinical respiratory disease.
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Previous work has demonstrated an association between hyperactivity and increased body lead burdens in school-age children. In the present study it is shown that within a group of hyperactive children those for whom an organic etiology is present have lead burdens lower than in those for whom no apparent cause could be found. These data lead us to reject the notion that hyperactivity per se is responsible for the acquisition of elevated lead levels, and further strengthen the suspicion that for some children lower lead level absorption may be implicated in the development of the hyperkinetic disorder.
The lower esophageal high pressure zone (HPZ) was characterized manometrically and reflux status determined in eight male rhesus monkeys. The studies were repeated six weeks and six months after 50 per cent distal small bowel resection. At the same time fasting serum gastrin and gastric inhibitory polypeptide values were assayed. In seven animals precise antrectomy with gastroduodenal anastomosis was performed and the studies repeated. HPZ pressure increased from 6.7 +/-0.67 mm Hg (+/-1 SEM) to 10.3 +/- 0.76 mm Hg at six weeks (p less than 0.005). At six months the pressure was 9.3 +/- 1.02 mm Hg (p less than 0.02) and after antrectomy 15.2 +/- 3.1 (not significant from 6 month value, p less than 0.02 from control). Serum gastrin and GIP values showed significant elevations at six weeks, but six month and postantrectomy results were not statistically different from control. Reflux episodes for the group were reduced at six weeks and six months. After antrectomy increased reflux was noted.
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Attenuation values were obtained from 50 CT examinations of the upper abdomen. A normal range of values, obtained for the organs in the upper abdomen, was compared with patient size and age. Rank ordering according to the mean attenuation values was also performed. The most significant finding was that the liver normally had the highest attenuation value of any of the viscera measured. When another organ in the upper abdomen had a mean value greater than that of the liver, this reflected severe systemic disease.
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