Search PubMed⌕ Search

Biomedical subjects

J Clark

Publications and source records attributed to J Clark.

At least 487 records · Page 27Linked to original sources
PubMed1977

The significance of pulmonary changes associated with cerebral perfusion with hypoxic blood in monkeys.

Parameters of cerebral and pulmonary function were studied in ten animals whose brains were perfused with hypoxic right atrial blood according to the Moss method. All animals died as a result of cerebral hypoxia at about 95 minutes after the onset of perfusion. Gross pulmonary congestion, edema, and leukocyte plugs occurred in the seven animals breathing spontaneously, but positive pressure ventilation prevented these changes in three. The resumption of cerebral perfusion with oxygenated blood after 30 minutes of the Moss procedure did not prevent the pulmonary changes and, of more importance, did not prevent cerebral swelling and death at about the same time as that of all the other animals. There were no changes in oxygen uptake or in arterial oxygen tension to indicate that progressive pulmonary failure contributed to death. It is concluded that this model produces brain swelling and brain death with incidental pulmonary pathological changes indistinguishable from early findings in hemorrhagic shock models and that the cerebral hypoxic perfusion model in monkeys is not suitable for studying the effects of "shock lung" therapy.

Animals↗
PubMed1976

Low lead levels and mental retardation.

Borderline and mildly retarded children attending the hospital developmental evaluation clinic were divided into two groups on the basis of the presence or absence of a pred with a paediatric control group using blood-lead concentration as the independent variable. Children with a history of diagnosed lead posisoning were excluded from the study. The group of mentally retarded children "aetiology unknown" had statistically significantly raised blood-lead concentrations but the mentally retarded sample with "probable aetiology" showed no significant difference in lead concentrations from those of the normal controls. It is concluded that the association between lead and mental retardation extends over a much wider range than hitherto suspected and that the nature of this association is independent of a history of "encephalopathic" lead poisoning. It is suggested that physicians should consider raised lead levels in their examination of all children suspected of mental retardation and that the numerical definition of lead toxicity should be re-evaluated.

Child↗
PubMed1976

Family planning.

Explore the source record for details and available documents.

Family Planning Services↗
PubMed1976

Non-deflating Foley catheter.

The different methods of removal of a non-deflating ureteral catheter were compared with the stylet technique. Two hundred and sixty randomly selected catheters were tested. Overdistention of the balloon with water or air and chemically induced rupture of the balloon produced fragments of various sizes in almost 100%. Our stylet technique failed to demonstrate any of the complications reported in the literature i.e., chemical or mechanical injury to the bladder or retained rubber fragments causing stone formation.

Humans↗