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Biomedical subjects

J Clark

Publications and source records attributed to J Clark.

At least 451 records · Page 25Linked to original sources
PubMed1979

Pseudomonas sternotomy wound infection and sternal osteomyelitis. Complications after open heart surgery.

Pseudomonas aeruginosa sternotomy wound infections occurred in five patients who underwent open heart surgery. The initial isolate in each case was from a mediastinal chest tube routinely cultured on removal. Soft-tissue infection developed in two patients, and sternal osteomyelitis developed in three patients. Pseudomonas-typing studies showed a correlation between five isolates from chest-tube suction pumps used postoperatively and the wound isolates. Analysis of antibiograms of Pseudomonas wound isolates from the cardiac surgery ward from 1975 to 1977 showed eight of 15 with the same antibiogram as the sternotomy pathogens, compared with two of 13 isolates from other wards.

Cardiac Surgical Procedures↗
PubMed1979

Distribution of plasma-bound hydroxyproline in breast cancer, benign breast disease and healthy females.

In normal adult females, patients with benign breast disease and patients with breast cancer, hydroxyproline (OHPro) was found in the plasma attached to the protein fractions which were separated by Sephadex gel filtration. In addition, a distinct moiety, probably a protein sub-unit, containing substantial amounts of this imino acid, occurred in between gel filtration fractions III and IV. Quantitative differences in the OHPro content of these various fractions were observed in the groups of patients studied. Significant elevations in the peptide-bound OHPro (fraction IV) were found only in patients with breast cancer and the level appeared to correlate with the degree of advancement of the disease. Similar findings relate to the OHPro content of the sub-protein moiety which is found between gel filtration fractions III and IV. A reduced level of high molecular weight hyproprotein (fraction I) was found in the breast cancer group.

Breast Diseases↗
PubMed1979

The British National Health Service 1948-1978: should we start again?

The author concludes that since the British National Health Service is the product of a complex history, it is impossible th start again: however, the removal of three factors and the development of one would greatly improve it. The factors to be removed are: (i) the witch hunt against management, which has become the scapegoat for other ills; (ii) the medical model of health care, which is no longer relevant or practical; (iii) the industrial model, which has forced the NHS into an inappropriate style of management, trade unionism and employment patterns. The factor to be developed is the clinical skill of the nurse; such development requires improved educational opportunities and a clinical career structure.

Collective Bargaining↗
PubMed1978

Visual evoked cortical potentials in men during compression and saturation in He-O2 equivalent to 400, 800, 1200 and 1600 feet of sea water.

Visual evoked cortical potentials and related EEG activity were recorded from subjects during rapid compression and exposure to pressures of 400, 800, 1200 and 1600 fsw. In one phase, subjects made repeated excursions to 1200 fsw from a base at 800 fsw; in the second phase, the saturated base was 1200 fsw with excursions to 1600 fsw. The results included: (1) For the visual evoked potentials, sizeable and significant decreases in amplitude and increases in latency of the response with depth; (2) Changes in the visual evoked potentials which varied systematically with depth but not with related changes in compression rate or decompression. The changes were small but consistent alterations of normal responses to visual stimulation; and (3) Theta activity in discrete EEG recordings increased progressively with depth. With all subjects showed increases in theta activity the pattern of increase varied individually.

Alpha Rhythm↗
PubMed1978

Tracing the fate of oxygen consumed during phagocytosis by human neutrophils with 15O2.

1. The metabolism of oxygen by phagocytosing neutrophils was traced by using 15O2. 2. The isotope did not exchange with the incubation medium or cells to an appreciable extent and unmetabolized oxygen was readily eluted by gassing the cell suspension. 3. The polarographic measurements of oxygen consumption closely paralleled the recovery of metabolized 15O2. 4. Almost all the metabolized 15O2 was converted into water, both in the presence and absence of KCN, supporting the concept that the oxygen consumed by neutrophils is converted into H2O2. It is unlikely that an appreciable proportion of this oxygen is incorporated into the organic composition of the cell or of the ingested micro-organism.

Humans↗
PubMed1978

Value of laparoscopy in the diagnosis and management of pancreatic carcinoma.

Our experience with laparoscopy in the diagnosis and staging of 23 cases of pancreatic cancer is reported. This endoscopic procedure has proved useful in the diagnosis of the disease, in the assessment of operability, and in the retrieval of material for histological and cytological confirmation of pancreatic cancer. An infra-gastric laparoscopic method for inspection of the body and tail of the pancreas is described and the technique may allow the earlier detection of neoplasms in this region.

Adult↗