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Biomedical subjects

J Clarisse

Publications and source records attributed to J Clarisse.

At least 55 records · Page 3Linked to original sources

[Dorsal disc herniation. 13 cases].

Thirteen patients with thoracic disc herniation have been operated on between 1960 and 1984. Nine presented with a progressive cord compression syndrome affecting sensory function more than motor. Four patients presented with acute cord compression. During this period, the authors have abandoned medullary angiography and myelography. The diagnosis is now based on computerised myelotomography. Three cases were treated by laminectomy with two postoperative deteriorations. Two cases were treated by a transthoracic approach which seemed to be too risky. Eight cases were treated through a postero-lateral approach, six being through a transverse arthropediculectomy using a microscope for better dissection of the vessels and Harrington rods to avoid secondary kyphosis. Seven of 9 cord syndromes were improved. Four cases with predominantly radicular syndromes were all improved.

Adult↗

Management of cavernous sinus meningiomas.

The management of intracavernous meningiomas remains controversial. The variety of methods of treatment reflects the difficulty of treating primary meningiomas of the cavernous sinus. Twelve personal cases and a review of the literature permit a choice between a direct surgical approach with or without radiotherapy, only radiation therapy or with no therapy. We think therefore that meningiomas of the cavernous sinus should nowadays be the subject of a surgical biopsy followed by radiotherapy according to their grading.

Adult↗

Medical treatment of hyperprolactinemia.

The current treatment of choice for primary hyperprolactinemia is medical. This is true not only for idiopathic forms, but also for micro- and macroprolactinomas, which are the most frequent causes of this pathology. Although questioned by some authors, the slow evolution of the illness, the rarity of transformation of a microadenoma into a macroadenoma, and the possibility of spontaneous cure cause most authors to favor medical treatment, with which they observe both normalization of gonadal function and tumor regression. By retrospective analysis of 95 hyperprolactinemic patients (72 women and 23 men including 26 cases of suspected microadenoma and 44 macroadenomas) treated with 3 dopamine agonists (bromocriptine, metergoline and CU 32085) between 1975 and 1983, and with the help of large series published in the literature, we have tried to review the present knowledge of this subject. After a quick review of different medications, we will consider their prolactin-suppressing effects, their influences upon gonadal and gonadotropic functions, and their antitumoral action. More specific problems will then be discussed: side effects, resistance, possibility of cure, the evolution of the prolactinoma, the place of medical therapy relative to surgery, and contraception in association with dopaminergics.

Adenoma↗

[Hydro-syringomyelic cavities. Contributions of x-ray computed tomography and nuclear magnetic resonance. Value of syringoperitoneal shunt].

Twenty one patients with a spinal cord cavity are reported: 14 presented syringomyelia, 3 had a syringomyelic syndrome of another etiology, 4 had clinical symptoms different from those usually observed with such cavities. All patients had a plain C.T. and 20 had a C.T. of cervical and thoracic spinal cord 6 hours after cervical myelography with metrizamide or iopamiron. Morphologic and dynamic features given by this examination are reported. They allowed a discussion about the pathogenesis of the cavity: some cases were consistent with Gardner's theory, but the majority were consistent with Aboulker's. Nine patients had an examination by magnetic resonance imaging which gave the morphologic features necessary for the treatment: spinal cord cavity, Chiari malformation, hydrocephalus. Eleven patients were treated by a syringoperitoneal shunt: in spite of the short follow-up, the results seem favourable, especially for sensitivity and trophic troubles. Surgery should be based upon aggravating course and hydrocephalus. The results of syringoperitoneal shunting allow new considerations about pathogenesis.

Adult↗

[Indications for selective embolizations in maxillofacial pathology].

There has been remarkable progress in the therapy of maxillofacial disorders, mainly as a result of the development of Djinjian and Merland's techniques for the exploration and selective embolization of the region supplied by the external carotid artery. These methods facilitate management of bone and skin angiomas and help to resolve problems of therapeutic arteriography for orofacial tumors. Two particularly hypervascular types of tumor: nasopharyngeal angiofibroma and carotid glomus tumor, as well as the hemorrhagic complications of facial epitheliomas, are conditions in which extremely useful data is obtained. Post-traumatic arteriovenous fistula can be treated by introducing inflatable balloons that are releasable or linked to a catheter. Acute severe epistaxis following injury responds to emergency embolization of the external carotid artery branches.

Arteriovenous Fistula↗

[Primacy of medical treatment of cerebral abscesses (19 cases)].

Therapy in 19 consecutive cases of cerebral abscess was limited to medical treatment whenever possible, using high doses of a combination of several antibiotics. Long-term follow up by serial computed tomography was performed. Antibiotic treatment alone was effective in 8 patients with multiple hemispheric abscesses of metastatic origin, though one patient seen late with three large abscesses die on the 4th day. In 8 cases with single abscesses, medical treatment alone was effective: 5 had lesions less than 4 cm in diameter; in 2 cases with lesions 4 to 5 cm in diameter, additional abscess puncture was carried out. One patient required early excision of an occipital abscess, and 2 cases of pontocerebellar angle abscesses were also treated surgically. Antibiotic therapy alone was effective in 1 patient with a large brain stem abscess. Treatment of cerebral abscess has largely changed since the availability of computed tomography, with a progressively more important place being accorded to antibiotic therapy alone. The stage of the abscess does not appear to be a decisive factor in the choice of treatment, medical therapy appearing to provide a definitive cure with a minimum of sequelae in the majority of cases. Abscess puncture may be an adjunct to antibiotic therapy in large abscesses with clinical signs.

Adolescent↗

[Septo-optic dysplasia. Apropos of a new case report].

Septo-optic dysplasia was detected in a 3 month-old boy. Abnormalities consisted of agenesis of septum lucidum as shown by cerebral CT scan and of hypoplasia of optic nerves resulting in pendular nystagmus and visual impairment. A slight visual improvement was observed at 10 months of age. Growth curve was normal and blood GH determination was not performed. Rubella infection had occurred in the 2nd month of pregnancy with rising antibody titers up to the 7 1/2 month.

Adult↗