Search PubMed⌕ Search

Biomedical subjects

J Clancy

Publications and source records attributed to J Clancy.

At least 91 records · Page 5Linked to original sources
PubMed1983

Panic disorder and primary unipolar depression. A comparison of background and outcome.

Outcome at discharge and during a follow-up averaging 5 years clearly distinguished 116 panic disorder inpatients from 123 age- and sex-matched inpatient controls with primary unipolar depression - 60.2% of the primary depression patients recovered at some time during follow-up compared to only 15.5% of the panic disorder patients. Differences in recovery rates grew larger with increasing follow-up length and were undiminished by the exclusion of patients who received antidepressants or convulsive therapy. Furthermore, these two groups had no predictors of outcome in common. These findings accord with other family and follow-up studies in support of a clear separation between panic disorder and primary depression.

Adolescent↗
PubMed1982

Excess mortality in panic disorder. A comparison with primary unipolar depression.

We located 113 former inpatients with panic disorder 35 years after index admission. According to age- and sex-specific Iowa population figures, patients with panic disorder had significant excess mortality due to death by unnatural causes. Other studies suggest that secondary depression and alcoholism may have had a role in these deaths. Men with panic disorder also exhibited excess mortality due to circulatory system disease. In an age- and sex-matched patient group with primary unipolar depression, both men and women showed excess mortality. Suicide accounted for 20.0% and 16.2% of deaths in the panic disorder and primary depression groups, respectively. We conclude that panic disorder accounted for much of the excess mortality formerly noted in the "neuroses."

Agoraphobia↗
PubMed1982

Acute lethal graft-versus-host disease stimulates cellular proliferation in the adult rat liver.

The present investigation was designed to analyse the effects of acute lethal graft-versus-host disease (GVHD) in adult (DA x LEW)F1 rats on cellular proliferation within the liver. The influence of the host thymus on GVHD-induced proliferation was also assessed. From 1-28 days after initiation of GVHD [3H]thymidine ([3H]-TdR) was injected i.v. and rats were killed one hour later. Percentage labelled cells (LI) of periportal infiltrating cells (PIC), hepatocytes (H), and sinusoidal lining cells (SC) were counted. Mean values for control rats were 0.3 +/- 0.1% (H), 0.4 +/- 0.1% (SC) and 0.2 +/- 0.1% (PIC). GVHD rats demonstrated a significant increase in LI of PIC (days 1-21), SC (days 2-17) and H (days 2-17). Most labelled cells in PIC were large lymphocytes. Peak LI values were 7.0 +/- 1.0% PIC (day 17), 6.8 +/- 0.9% SC (day 17), and 5.2 +/- 0.9% H (day 7), with all cellular compartments returning to near normal LI values by day 28. Stimulation of cellular proliferation occurred in all three liver cell compartments in neonatally thymectomized (TXM) rats. The intensity of GVHD-induced cell proliferation was significantly decreased at day 7 in all compartments and PIC was dramatically decreased at day 21 in TXM-GVHD rats as compared to non-TXM-GVHD rats. It is hypothesized that the general stimulation of hepatocyte cell proliferation in GVHD is related to the secretion of lymphokines by primarily donor and secondarily host T cells in the periportal infiltrate.

Animals↗
PubMed1981

A rapid technique for detecting IgGFc and complement receptors on T and B cells in the neonatally thymectomized and normal adult rat.

Numerous studies have demonstrated the presence of IgGFc and C3 receptors on mammalian lymphoid cells. However, the further characterization of these cells as T, B, or null has been cumbersome and time consuming. A simple method is described for surface fluorescent labeling of (DA X L)F1 rat cell suspensions indirectly with either anti-rat IgM (sIg+) or monoclonal anti-rat thymocyte (sT+) antibody and then rosetting with EA or EAC. Staphylococcus protein A had no significant effect on the level of sIg+ or sT+ attained. From 58-78% of IgGFc+ cells were SIg+ with 14-18% sT+ in the spleen, lymph nodes, and peripheral blood. Almost 100% of C3+ cells were sIg+. Neonatally thymectomized adults exhibited a 254-413% decrease in sT+ cells but a 154-329% increase in sIg+ and a 177-330% increase in null cells. They also exhibited a 140-400% increase in IgGFc+ and C3+ cells in all lymphoid compartments. Fifty-two to 65% of IgGFc+ cells and again almost 100% of C3+ were sIG+. The methods and results are discussed as a basis for studies of B and T lymphocyte maturation and function within various rat lymphoid compartments.

Animals↗
PubMed1981

Another Colicin V phenotype: in vitro adhesion of Escherichia coli to mouse intestinal epithelium.

Two assays were designed with which isogenic laboratory strains of Escherichia coli K-12 with and without ColV plasmids were compared for their ability to adhere in vitro to mouse intestinal epithelium. In both assays, disks of intestinal tissue were exposed to bacteria. In the first, disks were homogenized and the numbers of viable bacteria adherent to them were estimated from colony counts of plates inoculated with dilutions of the homogenates. In the second, bacteria were labeled with [(14)C]aspartic acid; the number of adherent cells per disk was estimated by liquid scintillation spectrometry. Data from each assay were compared by analysis of variance. In both assays, strains bearing the ColV plasmid adhered in two- to threefold-greater numbers than isogenic strains without the plasmid. These differences were highly significant statistically. A non-colicinogenic strain free of the ColV plasmid was selected by treatment of a ColV strain with sodium dodecyl sulfate. In the radioisotopic assay, the ColV strain associated with the epithelium in significantly greater numbers than the cured derivative. A ColV strain was created by conjugation; in the radioisotopic assay this strain bound to epithelium in significantly greater numbers than the recipient strain without the plasmid. The original ColV strain, when negatively stained and examined by electron microscopy, had pili that adsorbed male-specific bacteriophage, whereas its isogenic variant without ColV did not. Some such properties, coded by the plasmid, may increase the virulence of the bacteria.

Animals↗
PubMed1980

The prognosis of anxiety neurosis.

One hundred twelve anxiety neurotics originally seen in the medical clinics of a university hospital were interviewed after six years, and their outcome was compared with that of 110 surgical control subjects. Although socially impaired to a greater extent than control subjects, the majority of patients with anxiety neurosis, despite persisting symptoms, were shown to have a favorable outcome. Sixty-eight percent were either recovered or mildly impaired at follow-up examination. Of the prognostic variables examined, duration of illness and social class proved predictive of outcome. Secondary depression, which was reported by 44% of the neurotic subjects, represented the most frequent and potentially serious complication.

Adult↗
PubMed1980

Propranolol in chronic anxiety disorders. A controlled study.

In a double-blind crossover study the beta-adrenergic blocking drug propranolol hydrochloride reduced symptoms in 17 of 26 patients with chronic anxiety disorders. Both somatic and psychic symptoms improved as judged by patient and observer ratings. The most frequent side effects (dizziness, fatigue, and insomnia) were difficult to distinguish from anxiety symptoms and were, for the most part, mild. The therapeutic and side effects observed suggested CNS activity of the drug. Although propranolol is of benefit to patients with anxiety, its efficacy, compared with that of other antianxiety drugs, has not been established.

Adolescent↗
PubMed1980

Acutely administered polychlorinated biphenyls (PCBs) decrease splenic cellularity but increase its ability to cause graft-versus-host reactions in BALB/c mice.

A single intraperitoneal injection of 1000 mg/kg body weight of a PCB mixture (Aroclor 1242) to adult male BALB/cc mice caused not only a relative spleen enlargement, but also an absolute spleen lymphocyte depletion. However, there was an enrichment of spleen T cells necessary to cause a graft-versus-host reaction (GVHR) in (C3H x BALB/c) F1 neonates. The effect was present 6 days after PCB administration and was no longer present on days 12-13. These studies suggest a transient effect of acutely administered PCBs on splenic lymphocytes (B cells, null cells, some T cells) other than mature GVH inducing T cells. The effect may be either similar to or possibly indirectly mediated by corticosteroids.

Animals↗
PubMed1980

Effects of adult F1 thymocytes on graft-versus-host splenomegaly and homing of parental normal and cortisone-resistant thymocytes in F1 neonates.

In Simonsen assays parental cortisone-resistant thymocytes (P-CRTs) accounted for all of the thymic graft-versus-host reactivity (GVHR) of 3- to 6-week-old BALB/c males in (C3H X BALB/c) (CBF1) neonatal recipients. In the course of these studies, it was observed that coinjection of P-CRTs with large numbers of normal CBF1 thymocytes (F1 NTs) significantly reduced the GVHR of the P-CRTs as measured in Simonsen splenomegaly and [3H]TdR splenic proliferation assays. Homing experiments indicate that one explanation for the reduction in GVHR was a specific decrease in the homing of P-CRTs to spleens of F1 neonatal hosts when P-CRTs were coinjected with F1 NTs.

Animals↗