Acutely administered polychlorinated biphenyls (PCBs) decrease splenic cellularity but increase its ability to cause graft-versus-host reactions in BALB/c mice.

J W Carter; J Clancy

doi:10.1016/0162-3109(80)90018-1

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Acutely administered polychlorinated biphenyls (PCBs) decrease splenic cellularity but increase its ability to cause graft-versus-host reactions in BALB/c mice.

J W Carter·J Clancy

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Abstract

A single intraperitoneal injection of 1000 mg/kg body weight of a PCB mixture (Aroclor 1242) to adult male BALB/cc mice caused not only a relative spleen enlargement, but also an absolute spleen lymphocyte depletion. However, there was an enrichment of spleen T cells necessary to cause a graft-versus-host reaction (GVHR) in (C3H x BALB/c) F1 neonates. The effect was present 6 days after PCB administration and was no longer present on days 12-13. These studies suggest a transient effect of acutely administered PCBs on splenic lymphocytes (B cells, null cells, some T cells) other than mature GVH inducing T cells. The effect may be either similar to or possibly indirectly mediated by corticosteroids.

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Animals Female Graft vs Host Reaction Mice Mice, Inbred BALB C Organ Size Polychlorinated Biphenyls Spleen Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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J W Carter, J Clancy. 1980. Acutely administered polychlorinated biphenyls (PCBs) decrease splenic cellularity but increase its ability to cause graft-versus-host reactions in BALB/c mice.. https://doi.org/10.1016/0162-3109(80)90018-1

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