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Biomedical subjects

J C Patel

Publications and source records attributed to J C Patel.

At least 145 records · Page 8Linked to original sources
PubMed1978

[Assessment of postoperative infective risk by delayed hypersensitivity tests. The influence of deficient nutrition and its correction (author's transl)].

Cellular immunity was assessed in 120 patients by simple skin tests (tuberculin, candidine, varidase, C.C.B., trichophyton). There is a close relationship between total anergism and the risk of severe infection in digestive surgery, and between anergism and deficient nutrition as determined by laboratory and anthropometric criteria. Preoperative correction of nutritional deficiency, which is often underestimated, has an inconstant effect upon skin test responses, but seems to decrease severe postoperative infective complications.

Adolescent↗
PubMed1978

[Ulcers of the neck in hiatal hernias. Perforation into the free peritoneum (author's transl)].

Perforation into the free peritoneum of ulcers of the neck of hiatal hernias is a rare complication. On the basis of one case, which would appear to be the third reported in the literature but the only one in which the special circumstances resulted in the diagnosis being made preoperatively, the authors propose a new therapeutic attitude based upon the physiopathology of ulcers of the neck, combining suturing and reduction of the hernia with anterior repositioning of the greater curvature of the stomach, mobilised according to Thal's technique, and thereby simultaneously producing an anterior hemi-valve.

Aged↗
PubMed1978

[Single centro-hepatic biliary cyst (author's transl)].

This is a rare condition, often presenting late as a result of compression of adjacent organs, as demonstrated by radiological examinations. Laparoscopy reveals only hepatic hypertrophy whilst the intrahepatic lesion is seen on isotope scan, its irregular appearance sometimes leading to confusion with metastatic disease. Study by scanner confirms its cystic nature. This dysembryoplasic nature of this lesion is now generally accepted, its origins lying in the vestiges of the hepatic ducts. Resection of the overling dome is the usual treatment of exteriorised biliary cysts. The evacuation of large central cysts may be associated with haemorrhagic complications as a result of decompression, which explains the need for slow evacuation or even the preference sometimes expressed for excision at the outset, in particular in the case of a left-sided lesion.

Cysts↗
PubMed1978

[Pancreatic transplantation. Implantation of auto and allografts of the pancreas into the gastric wall of the diabetic rabbit (author's transl)].

The author's studied pancreatic autotransplants and allotransplants in the gastric submucosa of the rabbit after removal of the pancreas. Pancreatctomy causes severe diabetes with hyperkaliemic acidosis which is always fatal with 72 hours. Auto or allotransplantation cures the diabetes within two to three days, and maintains normal glucose balance for about 60 days. Early death after transplantation occurred when the graft was totally ineffective. After transplantation, the blood sugar rose progressively towards the 15th day, then suddenly and definetely at the time of necrosis of the graft towards the 15th or 21st day. The follow up in some transplanted animals exceeded two months. The interest of the procedure resides in the implantation of a large critical mass (25 to 30% of the pancreas ) in a well-vascularised area, drained by the portal system, and permitting the digestive tract elimination of the pancreatic necrosis whether of vascular or immune origin.

Animals↗
PubMed1978

[Anaerobic bacteria in digestive surgery. Pathogenic role and prognostic incidence (author's transl)].

The authors isolated in common surgical practice 83 anaerobic bacteria mainly bacteroides and clostridia. They analyse their pathogenic role in relation to the site of sampling. Comparing the bacteriological results with a clinical study of 96 cases of generalised peritonitis, there appeared to be no significant differente between the prognosis in peritonitis and anaerobic bacteria and those without anaerobic bacteria. The mortality was identical in septicemia due to anaerobic and aerobic bacteria; jaundice was just as frequent in both series. However, the prognosis of peritonitis due to anaerobic bacteria seems better when antibiotic treatment is adapted to the bacteria, e.g. lincomycin, metronidazole. With regard to anaerobic bacteria, which represent only part of the fecal flora, it may be dangerous by selection of resistant strains to use prophylactic antibiotics as a routine; local treatment of the septic focus seems the most important. The pathogenic role of anaerobic bacteria in digestive pathology is far from clearly defined; one should not follow the fashion of using even specific antibiotics without justification.

Adolescent↗
PubMed1978

[Perforation of the abdominal esophagus and peritonitis (author's transl)].

Perforation of the abdominal esophagus is not exceptional, either after endoscopy of the esophagus or after surgery of hiatus hernia. The clinical symptoms are not always clear especially during surgery. Immediate diagnosis is however essential for any delay in treatment causes the mortality to rise from 15% to more than 60% for repairs carried out under septic conditions. The best surgical attitude is difficult to determine under these conditions.

Adult↗
PubMed1978

[Colonic preparation for surgery. Interest of digestive irrigation (author's transl)].

Colonic surgery is still relatively lethal and there is a morbidity related to the breakdown of sutures which seems linked to the quality of the colonic preparation. Although everyone agrees today that this preparation is necessary, the choice of the procedure remains debated. High flow rate digestive irrigation with a solution of 10% mannitol presents numerous advantages compared with standard preparations. It definitely ensures better emptying of the colon; its role on the colonic flora is variable, minor and transient, which raises the problem of complementary antibiotic therapy. The encouraging results with regard to septic post-operative complications should lead one to extend the indications and to undertake random studies after definition of strict criteria of comparison on large series to find the procedure best adapted to each situation.

Anti-Bacterial Agents↗