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Biomedical subjects

J C Patel

Publications and source records attributed to J C Patel.

At least 163 records · Page 9Linked to original sources
PubMed1977

[Diagnosis of hepatic metastasis by enzymatic assay. Value of gamma-glutamyltranspeptidase].

Variations in serum enzyme levels were studied in 50 patients suffering from various types of neoplasm, 25 of whom had hepatic metastases. In the absence of any associated hepato-biliary or pancreatic disorder, gamma-glutamyl-transpeptidase would appear to be a reliable test in 96 % of cases. It represents a factor of assessment which merits a place in the prognostic study of all types of neoplasia.

Adult↗
PubMed1977

[Hydroelectrolytic disturbances secondary to high flow lavage used for the prevention of posthemorrhagic encephalopathy in cirrhosis].

The authors carried out high flow intestinal lavage during gastrointestinal bleeding in cirrhotics in order to obtain rapid elimination of blood from the intestine and thereby reduce the risk of encephalopathy. The fluid used had been developed for preparation of the colon for surgery and was responsible for water and electrolyte disturbances with water and salt retention. Without criticising the principle of lavage in the prevention of encephalopathy, the authors express certain reserves with regard to the use of this solution and suggest the use of a sodium-free substance remaining within the intestinal lumen (hypertonic mannitol) which does not cause any water/electrolyte imbalance, is more effective and would appear to have a slight though definite action on the resorption of ascites.

Brain Diseases↗
PubMed1977

[Continuous and interrupted intestinal sutures. Experimental and clinical study (author's transl)].

The authors report a clinical study of 101 cases of continuous digestive suture and an experiment comparing intestinal healing after continuous and interrupted sutures. A certain discrepancy exists between the excellent clinical results and the pathological and microscopic findings with continuous sutures, and in particular the presence of pseudo-diverticular pouches in 20% of cases developing at the expense of a mucosal evagination within the suture. If carefully performed, continuous suture seems excellent, preventing by its watertightness, the onset of early fistula.

Animals↗
PubMed1977

[Intestinal mechanical sutures: macroscopic and histological aspects (author's transl)].

The authors studied healing in digestive sutures carried out using automatic clips in the Dog. The mechanical conditions of the suture and in particular the absence of crushing are responsible for an almost perfect scar healing by first intention. The absence of ischemic necrosis remains the main factor differentiating these sutures from manual sutures where necrosis is constant, whether due to repeated trauma from forceps or ischemia due to tightening the threads, and above all, constant inclusion of the mucosa within the scar. The use of non-ischemic sutures explains undoubtedly the low incidence of fistulas, but explains, on the contrary, the large number of cases which bleed from the divided margins of the sutured or anastomosed layers; in rare cases, severe bleeding requires reoperation. These sutures are everted sutures causing a significant number of adhesions. We did not find any significant difference in the healing of inverted or everted sutures from the 15th day onwards.

Animals↗
PubMed1977

[Rational use of antibiotics in digestive surgery].

The abusive and inappropriate use of antibiotics in digestive surgery has led to the selection of multi-resistant strains responsible for sometimes dramatic infective complications. The study of the normal digestive flora under pathological conditions, knowledge of the mechanisms of resistance, led us to propose the use of antibiotics with circumspection, depending on the germ isolated and the probable efficacy of the drugs. Prophylactic antibiotic therapy is only justified with regard to gram positive anaerobic bacteria or, in exceptional cases, where the risk seems high and may irremediably compromise the surgical procedure. Curative antibiotic therapy, after treatment of the infective focus, is often sufficient but depends on the bacteria: Whether anaerobic, staphylococci of Gram negative bacilli, with regard to which one should use narrow spectrum single antibiotics.

Anti-Bacterial Agents↗
PubMed1977

[Electric study of myotomy of the small intestine (author's transl)].

The electric activity of the small intestine above and below an oblique myotomy was studied in the rabbit. In most cases, there was noted a definite increase in the amplitude of the electric recording above the functional obstruction showing increased peristalsis. This phenomenon seems to become attenuated with time, perhaps owing to the technical conditions of this study. Myotomy of the small intestine seems, in the light of these recordings, to be very efficacious. The authors compare it with other procedures which may be used to slow intestinal transit and suggest carrying out long or multiple myotomies, perhaps associated with one of the other techniques to increase the efficacy.

Animals↗