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Biomedical subjects

J C Patel

Publications and source records attributed to J C Patel.

At least 127 records · Page 7Linked to original sources
PubMed1983

[Colonic occlusions. Retrospective cooperative study of 497 cases].

A retrospective multicenter study involving 12 digestive surgery centers was conducted on 497 cases of colon obstruction. The most frequent cause of colon obstruction was colo-rectal cancer (71 p. cent of cases), but many other etiologies were involved, including 61 cases of torsion and 37 patients with occlusive sigmoiditis. Differential clinical and radiological features in each etiological group are discussed, the results of therapy undertaken analyzed, and a reasonable line of conduct proposed, adapted to each situation, with the objective of attempting to reduce mortality which still affects 25 p. cent of cases operated upon.

Adult↗
PubMed1982

[Indications and future of the Hartmann operation. Cooperative study of 126 cases (author's transl)].

The main indications for the Hartmann operation are cancer and sigmoiditis. It is done as an emergency in 70% of the time, more often for peritonitis, generally from diverticulitis. (45% of the time) than for occlusion usually due to cancer (30% of the time). The high mortality (33%) is due to the precarious condition of the patients, and only 25% are due to the operation, usually from disruption of the rectal stump. The reestablishment of the intestinal continuity, now facilitated by the clip forceps, was possible in 37 cases with no mortality. This represents 28.9% of the group, but only 52.1% were alive six months later. Only 6.8% of the cancer cases were benefited; however, 51% of the sigmoiditis cases and 87.5% of the cases of traumatic perforation were benefited. These results plus the advantages furnished by the autosuturing forceps justify renewal of interest in this operation first described 60 years ago.

Adult↗
PubMed1981

[Pre-operative preparation of the colon: a controlled prospective multicentre study in 215 patients (author's transl)].

Three procedures for pre-operative preparation of the colon were compared during a controlled multicentre study in 215 patients. Though mechanical irrigation with a 10 p. cent mannitol solution is definitely superior as far as the degree of intestinal emptying obtained, no significant difference was noted in the frequency or severity os postoperative infections after conventional preparations by digestive tract irrigation with or without intestinal antibiotics. This method is limited by its tolerance (67 p. cent), its advantages are its rapidity and cost, elective indications being ascending colon lesions with little or no stenosis in young subjects. In other circumstances it has to be compared with the conventional methods of preparation, which should still be employed before operation in subjects who are elderly and/or have moderate to severe stenosis. The addition of antibiotics (neomycin, metronidazole by mouth) reduces the incidence of postoperative sepsis to a marked but non-significant degree, independently of the lesion (cancer, sigmoiditis) and its site. A recent study by F. Lazorthes has led him to prefer an association of antibiotics active against aerobic and anaerobic flora: orally preoperatively, and systemically during surgery.

Adult↗
PubMed1981

Bronze diabetes.

Explore the source record for details and available documents.

Adolescent↗
PubMed1981

[Biliary regeneration. Experimental studies in rats (author's transl)].

Cholangiographic and histological examinations after partial hepatectomy in rats have demonstrated the presence of biliary as well as hepatocyte regeneration. Commencing very soon after hepatectomy, biliary degeneration is confirmed by radiological investigation, showing hypertrophy of the intra-hepatic biliary canals, and corroborated histologically by evidence of mitoses in the biliary epithelium. This suggests that intravenous cholangiography can be a simple means of evaluating hepatic regeneration after partial hepatectomy in humans.

Animals↗
PubMed1980

[Hyperalimentation after digestive surgery: influence on immune state and on prognosis (author's transl)].

Immunocompetence was measured in 320 gastrointestinal surgery patients using the delayed hypersensitivity test. The frequency of complications and death from sepsis was greater (p less than 0,001) in anergic patients (39%) than in patients with normal response (5%). A close correlation was observed between anergy and malnutrition as determined on the basis of biological criteria (triceps skinfold, arm circumference, ratio between actual and deal weights). This double correlation led to study the influence of hyperalimentation on immune response and prognosis. Parenteral hyperalimentation with nitrogen and calories was administered to 26 anergic patients with heavy or complicated intestinal surgery (peritonitis) for from 10 to 37 days (av.: 19, 2 days). One or more test(s) had turned positive by the 10th day in 7 patients; by the 30th day in 16 and by the 69th day in 20. Out of 26 anergic patients, 19 were nutritionally normal; hyperalimentation had no influence on biological criteria and began to modify body measurements only after 17 days; in the 16 anergic malnourished patients,, hypernutrition led to the development of a positive nitrogen balance (3,60 +/- 1,7 days) and to a return within normal range of biological criteria (7,2 +/- 2,3 days), and body measurements (14,3 +/- 9,2 days). Death from sepsis in anergic patients with hyperalimentation was lower (11,2% and 44,4%; p less than 0,01) than in anergic ones without hyperalimentation. Hyperalimentation with nitrogen and calories modified the nutritional status, immunological response and improved prognosis in anergic patients.

Digestive System Surgical Procedures↗
PubMed1980

[Value of Noxyflex for peritoneal toilet in acute generalized peritonitis. A controlled study of 48 cases (author's transl)].

The efficacy of Noxythiolin in solution for peritoneal toilet during operation on 48 patients with acute generalized peritonitis was evaluated. The trial was prospective, with random selection of patients who were divided into two groups with identical backgrounds, initial affections, and therapies applied. No significant differences were noted in prognosis, bacteriological findings or subsequent course in the survivors in the two groups. The only favorable effect noted in the group treated with Noxythiolin was the frequency with which further operations had to be performed, but the difference was nos significant. Though the use of peritoneal antiseptics isjustified when positive bacteriological test are reported, the determining element in peritoneal toilet appears to be the volume of liquid employed, independently of its composition.

Acute Disease↗