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Biomedical subjects

J C Patel

Publications and source records attributed to J C Patel.

At least 109 records · Page 6Linked to original sources

[Volvulus of the gallbladder. Apropos of a new case].

A case of volvulus of the gallbladder is reported, preoperative diagnostic of this rare lesion being difficult to establish in spite of the contribution of ultrasound imaging. The non-specific clinical findings suggest the need for cholecystectomy.

Aged↗

[Colectomy by combined resection-anastomosis using linear mechanical sutures].

In the technique described, anastomosis is started with a GIA mechanical stapler then completed with a TA stapler followed by resection of the segment involved. We prefer this technique to other mechanical procedures (triangulation, circular anastomosis) in all colectomies which do not require lower colorectal anastomosis. It is simple, economical and solves problems of incongruence. Finally--and this is the most important point in surgery of the colon--it considerably shortens the septic operative stages.

Colectomy↗

[Treatment of hepatic metastases].

Liver metastases usually result in death within 6 months, and excision is the only means of ensuring prolonged survival. Excision is justified in metastases, even multiple, localized in one lobe and arising from cancers of the colon or rectum, provided the cancer has apparently been adequately treated. Excision of metastases of other origins is disappointing. Among palliative treatments, infusion of antimitotic agents into the hepatic artery seems to give better results than dearterialization; implantable micropumps facilitate the infusion and prolong its duration. Embolization and radiotherapy mostly have an analgesic effect. Intravenous chemotherapy is much less effective.

Antineoplastic Agents↗

[Medical treatment of prostatic adenoma. Controlled trial: PA 109 vs placebo in 110 patients].

110 patients presenting with a prostatic adenoma sufficiently symptomatic to be treated medically, but not requiring surgical management, were included in a controlled test whose effectiveness was assessed after one month on the basis of objective criteria (nocturnal pollakiuria, urinary output, postmictional residue) and subjective criteria (dysuria, patients' opinions). PA 109 appeared significantly more effective than a placebo, especially in the objective criteria (p less than 10(-9]. Perfectly tolerated, clinically and biologically, this efficacy was again found in a supplementary study of forty seven patients, with a mean follow-up of 14.6 months, and over 2 1/2 years in some cases. Under the study conditions, and on the basis of the study criteria, PA 109 seems a good treatment for mictional disorders associated with non-surgical adenomas of the prostate.

Aged↗

[Paradoxical embolism through a patent foramen ovale. 4 cases].

Four cases of paradoxical embolism through a patent foramen ovale associated with massive pulmonary embolism are reported. In two cases, patency of the foramen ovale was demonstrated by a new technique: cross-sectional contrast echocardiography potentiated by coughing. The conventional surgical treatment included arterial embolectomy followed by insertion of a caval filter. Embolism recurred on three occasions under mechanical ventilation prior to insertion of the filter. A new sequence of investigations to facilitate detection of paradoxical embolism in patients with unexplained arterial embolism is suggested: (1) blood gas measurements, which reveal associated pulmonary embolism; (2) cough-potentiated cross-sectional contrast echocardiography, which demonstrates a patent foramen ovale and excludes emboligenic cardiopathies; (3) phlebography and pulmonary angiography which complete the diagnosis. To reduce the risk of recurrent embolism, it is recommended to begin treatment by blocking the vena cava without mechanical ventilation. This can be done by inserting a filter through the jugular vein under local anaesthesia. Arterial embolism can then be treated at lesser risk under mechanical ventilation.

Echocardiography↗

[Total gastrectomy. Primary esophagojejunal anastomosis, the organ in place, using linear mechanical suture staplers].

In "mechanical" surgery, continuity of the digestive tract may be re-established with either circular (E.E.A. - I.L.S.) or linear stapled anastomosis (G.I.A. - T.A.). For oesophago-jejunal anastomosis, the authors prefer the second method which provides wider anastomosis without the risk of stenosis attached to circular sutures. The stomach is kept for traction, thus facilitating the procedure, which can be performed through the abdominal incision.

Esophagus↗