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J C Huber

Publications and source records attributed to J C Huber.

At least 127 records · Page 7Linked to original sources
PubMed1987

[Stimulation of prolactin secretion by vasoactive intestinal peptide].

Dopamine has already been recognized as an inhibiting factor of prolactin. On the other hand, the stimulators of prolactin are still judged diversely at the moment. In addition to hypothalamic TRH, serotonine as well as endogenous opiates and VIP are under discussion. The object of our studies was testing the function of VIP in directing prolactin secretion on three different groups of patients: 1. hyperprolactinaemic women of WHO-group VI; 2. patients who had undergone a TRH-test along with an endocrine check-up; 3. post partum in childbed. The determination was made from analyzing peripheral blood by radioimmunoassay. In 20 amenorrhoeic patients of WHO-group VI, their prolactin and VIP levels were determined between 8 and 10 a. m. Only 4 patients showed a VIP-concentration below 20 pg/ml (which represents the limit of detectability). The other 16 patients showed an increased concentration of VIP. In 15 cases there was an obvious correlation of VIP and prolactin concentrations according to the linear regression. In the course of a TRH-test to 20 and 40 minutes after initial blood examination prolactin and VIP were again determined. After 20 minutes all patients showed a threefold increase of the initial prolactin value. On the other hand, VIP increased in 3 cases only. Apart from all those patients who wanted to become pregnant, these three women--being postmenopausal--showed increased initial values already in the unstimulated condition. The third group of patients consisted of 26 women in childbed. Their prolactin and VIP were determined between the second and eight day post partum.(ABSTRACT TRUNCATED AT 250 WORDS)

Female↗
PubMed1987

[Incidence of hyperandrogenemia].

Within two years 341 amenorrheic patients treated in our endocrinological outpatient department were listed up retrospectively in WHO-classification groups. In 30 patients a primary amenorrhea and in 311 patients a secondary amenorrhea could be registered. In 28.3% a hypothalamic pituitary disorder must be diagnosed, in 5.1% a hypergonadotropic profile was observed. Uterine amenorrhea was seen in 0.6%, a hyperprolactinemia in 6.1%. The hyperandrogenemia with an incidence of 42.1% is remarkable and should be included in the WHO-classification.

Adult↗
PubMed1987

[Endocrine profile of patients with post-pill amenorrhea].

"Post-pill amenorrhea" is still a much-debated subject in gynecological endocrinology. The authors therefore studied the reproductive history and endocrinological parameters of 145 patients with the presumptive diagnosis of post-pill amenorrhea, seen in their department during the last two years; 166 cases of secondary amenorrhea served as a control group. The incidence of late menarche (20%), previous oligomenorrhea, and elevated androgen serum levels was high in both groups. There were no significant differences between the two collectives. These findings suggest that although oral contraceptives may have an unfavorable influence on the menstrual cycle, there is no causal relationship between such agents and the development of secondary amenorrhea. It seems that in many cases of presumptive post-pill amenorrhea the common condition of juvenile hyperandrogenemic ovarian insufficiency might be the underlying problem.

Adolescent↗
PubMed1987

[Hyperandrogenemia as a cause of amenorrhea].

The so-called postpill amenorrhea remains a much debated subject in gynecological endocrinology. We have therefore scrutinized the reproductive history and endocrinological parameters of 145 patients with the presumptive diagnosis of postpill amenorrhea, seen at our department during the last two years. 166 cases of secondary amenorrhea served as a control group. Both groups showed a high incidence of late menarche (20%), previous oligomenorrhea and elevated androgen serum levels. There were no significant differences between both collectives. These findings suggest that although oral contraceptives may unfavorably influence the menstrual cycle, there is no causal relationship between such agents and the development of secondary amenorrhea. It seems that in many cases of presumptive postpill amenorrhea the common juvenile hyperandrogenemic ovarian insufficiency might be the underlying problem.

Adolescent↗
PubMed1986

[Simplified hamster ovum-sperm penetration test (HSPT) in routine sterility testing].

In 67 patients, in most of whom the spermiogram did not, a priori, furnish definitive proof of fertility, the hamster egg human sperm penetration test was performed as part of a screening programme for infertility therapy conducted from February 1984 to February 1985. Evaluation of the test was facilitated by identification of the decondensed spermatozoon head in the penetrated hamster egg with a simple fluorescein staining instead of the usual aceto-lacmoid staining. The penetration rate (= percentage proportion of the hamster ova liberated from the zona pellucida which are penetrated within 3 hours following incubation with 1 million motile spermatozoa) was evaluated statistically in comparison to the fertility criteria of the spermiogram (motility, density, pathoforms), in order to verify the existence of possible fertility disturbances due to inability to penetrate despite the motility of the spermatozoa. In 42 patients the diagnosis of infertility was confirmed by a penetration rate of less than 10%. In 17 patients fertility was conformed according to HSPT (penetration rate of over 20%), while in 7 patients fertility was in the lower normal range. In the light of the authors' findings fertility confirmed by the HSPT is a precondition of referral for extracorporeal insemination. In the light of the authors' findings intrauterine insemination appears advisable for women whose fertility is in the lower normal range according to HSPT.

Adult↗
PubMed1984

Maternal hyperventilation as a possible cause of fetal tachycardia sub partu. A clinical and experimental study.

Examination of 28 agitated, hyperventilating patients with fetal tachycardia showed that the mothers were in a hyperventilation-related state of hypocapnia and alkalosis. The mean maternal pCO2 was 17.48 +/- 6.79 mm Hg, the pH 7.54 +/- 0.14, which caused a reflex spasm of the umbilical veins, fetal acidosis and fetal tachycardia. Additional experiments on sheep revealed a similar correlation between maternal hyperventilation, hypocapnia, respiratory alkalosis and fetal tachycardia while the flow volume of the uterus showed no change.

Alkalosis, Respiratory↗
PubMed1984

[Serum plasminogen levels and timing of ovulation].

During diagnosis and treatment of female sterility, plasminogen and fibrinogen degraduation products were measured from patient's vein blood in the cycle of menstruation on the days round menstruation. On the days round ovulation and also before beginning of menstrual bleeding an elevated plasminogen level by unchanged fibrin(ogen) degraduation products was found. Therefore the plasminogen modulation as a causal factor for the rupture of follicles is discussed.

Anovulation↗
PubMed1983

[Amniotic fluid cytology and foetal lung maturity--a comparison with the dynamic surface tension measurement of the amniotic fluid for predicting foetal lung maturity].

79 samples of amniotic fluid in 69 pregnancies between 29-40 weeks of gestation were examined for foetal lung maturity (dynamic surface tension) and general maturity (Nile Blue cytological test). Both parameters were compared with the pulmonary maturity of the newborn post partum in 24 cases born within 72 hours after the last amniotic fluid examination. In 49 cases the Nile Blue cytological test showed mature values, in 24 cases immature - and in 6 cases borderline values. The dynamic surface tension measurement showed 55 mature, 19 immature and 5 borderline results. These findings show an earlier maturation of the foetal lung compared with the foetal sebaceous glands. Between 36 and 40 weeks of gestation we found a significant (p less than 0.01) correlation between the two methods. Between 32 and 35 weeks of gestation, the significance was less (p less than 0.05) and between 29 and 31 weeks of gestation no correlation could be found. The Nile Blue cytological test for lipid cells is easy to perform, requires less than 1 ml amniotic fluid and is not influenced by blood and meconium and shows no false positive results. Immature findings with the Nile Blue cytological test should be confirmed by other lung maturity tests, like LS-ratio or amniotic dynamic tension measurement. Therefore we can recommend this simple method for the screening of foetal lung maturity as well.

Amniotic Fluid↗
PubMed1982

[Real time ultrasound in routine breast diagnosis].

Ultrasound examination of the breast is used in three indications: the premenstrual syndrome, the examination of cyst and the short-time control of high-risk patients. The differential main point is the diagnosis of cysts, which may save the patient from "blind" puncture. In this field, ultrasound is more competent than mammography; furthermore, the oedematous changes occurring before the onset of menstruation can be easily seen with sonography. For the early detection of cancer of the breast, ultrasound is merely additional but its diagnostic value is bound to rise with progressing development.

Adult↗
PubMed1982

[Prognostic value of haematocrit in cases of severe EPH gestosis (author's transl)].

Haematocrit values were determined in 48 of 65 women hospitalised for severe EPH gestosis in 1979. Values in excess of 38 per cent were recorded from two thirds of the probands. An unambiguous correlation also was found to exist between gestosis severity, as reflected in gestosis index, and haematocrit values. False negative findings were obtained merely from mild cases, whereas false positive findings could be eliminated by repetitive measurement and resulting trend projection. -- Correlations were found to exist also between foetal outcome and elevated blood viscosity. These findings were likely to suggest that while classical gestosis symptoms might be aggravated by rise in haemoconcentration, via reduced perfusion resistance and increased peripheral vascular resistance, such higher haemoconcentration might deserve more attention for prognostication.

Adolescent↗