Search PubMed⌕ Search

Biomedical subjects

J Albrecht

Publications and source records attributed to J Albrecht.

At least 181 records · Page 10Linked to original sources
PubMed1982

The binding of insulin to cerebral capillaries and astrocytes of the rat.

The binding [125I]insulin and its displacement by the unlabeled hormone was measured in vitro in the isolated cerebral capillaries and astroglia cell-enriched fraction as well as in the particulate fraction of cerebral homogenate and liver plasma membrane preparation. The results indicate the specificity and affinity of the hormone binding to astrocytes to be similar to that to cerebral homogenate and liver fractions and markedly higher than to cerebral blood vessels. The possible functional significance of the insulin receptors on astrocytes is discussed.

Animals↗
PubMed1981

Cerebral RNA synthesis in experimental hepatogenic encephalopathy.

Cerebral slices from rats subjected either to chronic (2- to 6-month) administration of carbon tetrachloride or to prolonged (21-day) portocaval shunting showed an increased above control ability to incorporate (3H]uridine in vitro into the RNA of the large cell nuclei, mostly derived from astrocytes but not the small oligodendroglial cell nuclei. This result is interpreted to indicate that brain reacts to extended periods of hepatogenic insult or chronic omission of hepatic circulation with a stimulation of RNA synthesis in the astrocytes. The possible relation of this phenomenon to the characteristic astrocytes response accompanying hepatogenic encephalopathy is discussed.

Animals↗
PubMed1980

Renal function and biopsy in patients on lithium-therapy.

The renal function of 46 outpatients from a lithium-clinic was examined in detail during 5 days of hospitalization on a nephrological ward. Lithium medication was stopped seven days before admission. In approximately 25% of the examined patients, a lithium-induced nephropathia must be assumed. Irreversibility of the disturbances cannot be excluded. The characteristic feature of this patient population is to be seen in an exclusive reduction of the renal concentrating ability. Urine osmolality showed a significant negative correlation to the product of duration of treatment times lithium serum concentration. In all patients with a reduced GFR a preexisting kidney disease could be demonstrated. The degree of polyuria was not related to the observed impairment of renal function. On the average it took seven years until a reduced concentration ability became apparent; the minimal time interval was three years. The lithium-associated nephropathy may be characterized as a rather frequently occurring damage of the kidney interstitium being dependent on serum-lithium concentration and duration of treatment. Progress of these pathological changes is obviously very slow and accompanied by only few and mild clinical symptoms. Kidney biopsy in 4 cases revealed focal fibrosis and tubular degeneration as has been described by other authors.

Adult↗
PubMed1980

Tick paralysis in a western harvest mouse.

An engorging female Ixodes pacificus was observed on a western harvest mouse (Reithrodontomys megalotis) in Humboldt County, California. The mouse demonstrated a flaccid paraplegia, but it appeared to recover fully after the tick was removed.

Animals↗