[The myocardium in patients with ischemic heart disease].
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Biomedical subjects
Publications and source records attributed to I V Maev.
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The paper covers questions of the emergence and progressing of cardiorespiratory disturbances in coronary patients with defective atrioventricular conduction. The authors characterize central and peripheral hemodynamics in the above patients, diastolic ventricular filling, external respiration, the disturbances of which were studied in correlation with hemodynamic features and lipid peroxidation. The patients were examined for effects on their cardiorespiratory system of cardioselective beta-blockers, adrenomimetics, antioxidants, membrane stabilizers.
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The paper gives the data on hemodynamic features in patients with bundle-branch block. Based on the data available in the literature, the authors outline hemodynamic abnormalities occurring in various bundle-branch blocks, mechanisms of their development, influences of hemodynamic changes occurring in the blocks on the general condition of patients.
Electrocardiographic, echocardiographic and Doppler echocardiographic studies were performed in 44 patients with coronary heart disease and complete right bundle branch block. The patients were found to have an impaired phase pattern of left ventricular systole and diastole as more prolonged length of its isometric relaxation and contraction, lower economic feasibility and efficiency of its contraction, moderate dilation and hypertrophy. Hemodynamic abnormalities in the left heart in these patients are closely correlate with the changes in the phase pattern of right ventricular systole and they turn out to be so greater as the degree of its hypertrophy is. In complete right bundle branch block, left ventricular pump dysfunction leads to decreased cardiac output and cardiac index, increased total peripheral vascular resistance, thus predisposing to impaired greater circulation.
The authors carried out a complex clinico-instrumental investigation of the effect of a new cardioselective beta-blocking agent leprozor in 116 patients with hypertensive disease (stage II). A quantitative evaluation of the hemodynamics of the left compartments of the heart with two-dimensional echocardiography was carried out. Evaluation of the efficacy of using leprozor in this category of patients was based on an analysis of the state of their hemodynamics against the background of systematic intake of the drug for 7 months. Selection of the dosage was individual under the control of circulation parameters. It is concluded that leprozor proved effective in normalization of the hemodynamics in patients with hypertensive disease.
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A complex Doppler echocardiographic study was performed in 134 patients with complete block of the left bundle branch, its anterior branch or with concurrence of these two types of intraventricular conduction disturbance. The authors identified 5 types of paradoxical ventricular septal motion, which were related to the specific features of intraventricular asynchronism and ventricular electric systole. Type I shows the greatest decrease in left ventricular contractility, left atrial overload and phasic destruction of left ventricular systole, which reflects the processes of depolarization and repolarization propagation in the myocardium. Type IV is characterized by the lowest number of hemodynamic abnormalities. Cardiac hemodynamics is also related to the type of intraventricular block, being the least changed in isolated anterior left bundle-branch and the most changed in concurrent anterior branch and entire left bundle-branch block.
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Diagnostic potentialities of Doppler sonography in assessment of portal hemodynamics in patients with chronic active hepatitis and hepatic cirrhosis were compared to those of noninvasive (rheohepatography) and invasive (angiography) techniques. Dopplerograms of the portal vein and its branches are described in specific details. Meals and treatment with beta-adrenoblockers reducing portal hypertension are evaluated in relation to their influence on the portal hepatic circulation.
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The paper reviews literature data available and first-hand experience in relation to hemodynamics of portal blood flow, lesser and greater circulation in patients with chronic diffuse hepatic diseases. Relevance of circulatory changes to hepatic lesions is also considered. With regard to specific features of hemodynamic disturbances in hepatic lesions it is suggested to use cardiovascular drugs. A pharmacodynamic effect is compared for beta-adrenoblockers, calcium antagonists and nitrates administered to patients with affected hepatobiliary system.
The paper presents clinical and instrumental evidence on 47 patients with hepatic cirrhosis. The revealed ventilatory disorders and worse bronchial permeability closely correlated with the degree of pulmonary hypertension which in its turn depended on portal hypertension degree. Pulmonary hypertension decreased with a decline in the activity of the pathological process in the liver due to treatment. External respiration insufficiency observed in hepatic cirrhosis contributes to the onset of arterial hypoxemia and hypoxic impairment of the liver activating in it a pathological process. It is recommended that such patients should receive a combined treatment incorporating oxygen therapy, calcium antagonists, antioxidants.
Two-dimensional and Doppler echocardiographies were used to examine right cardiac and pulmonary hemodynamics in patients with various types of coronary heart disease (CHD). All the patients were divided into 3 morphofunctional groups of CHD according to the left ventricular volume/mass index. They all were found to exhibit decreased left cardiac contractility and pump function, parallel with moderately elevated pulmonary pressure and right cardiac compensatory hyperfunction, which was largely evident in hypertrophic morphofunctional CHD. The degree of pulmonary hypertension was related to the severity of left ventricular pump dysfunction, but to its disturbed contractility in the dilated type.
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