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Biomedical subjects

I Kondo

Publications and source records attributed to I Kondo.

At least 289 records · Page 16Linked to original sources
PubMed1979

Trisomy 12p syndrome: de novo occurrence of mosaic trisomy 12p in a mentally retarded boy.

The first case of trisomy of probable 12p mosaicism originated de novo is presented. Comparison of the clinical findings of this patient with those of previously described cases of 12p trisomy derived from translocated chromosomes indicates that the symptoms of 12p trisomy are: (1) normal birth weight and physical development, (2) severe psychomotor retardation and generalized hypotonia, (3) peculiarly round face with prominent cheeks, hypertelorism, epicanthus, broad, flat nasal bridge, short nose with anteverted nostrils, large philtrum, broad, prominent lower lip, and (4) poly(syn)dactyly of feet.

Chromosome Banding↗
PubMed1979

A case of trisomy 3q21 leads to qter syndrome.

An infant with karyotype 46,XY,der(8),t(3;8)(q21;p23) is presented. The presence of trisomy 3q21 leads to qter syndrome is suspected on the basis of comparison of the clinical and laboratory findings of this patient with those of cases that have been reported as partial 3q trisomy. The common phenotypic features of this syndrome include growth failure and mental or developmental retardation, hypotonia, persistent lanugo, distorted head, congenital glaucoma, short and upturned nose, prominent maxilla, micrognathia, short, webbed neck, short limbs, retroflexed third and fourth toes, cutaneous syndactyly of the second, third and fourth toes, and elevated galactose-1-phosphate uridyl transferase activity in the red blood cells.

Blood Group Antigens↗
PubMed1979

A case of Turner's syndrome with familial balanced translocation t(1;2)(q32;q21)mat.

The first case of Turner's syndrome with the familial translocation not involving the X chromosome is described. The patient had a number of clinical signs of Turner's syndrome and her karyotype was 45,X,t(1;2)(q32;q2)mat. Though it is speculated that the altered structure of a chromosome may influence meiotic disjunction of a non-homologous chromosome, our case suggests that there may be no relationship between the two chromosomal abnormalities.

Chromosomes, Human, 1-3↗
PubMed1978

A case of Turner's syndrome with hyperthyroidism.

A female patient with classical gonadal dysgenesis associated with Graves' disease is reported. The karyotype was mosaicism of 45,X/46,X,i(Xq). The relationship among Graves' disease, Hashimoto's thyroiditis and Turner's syndrome is discussed along with a review of the reported cases.

Adult↗
PubMed1978

Survey of resistance to metals and antibiotics in clinical isolates of Klebsiella pneumoniae in Japan.

Clinical isolates of K. pneumoniae (746 isolates) were studied for the resistance to four metals and four drugs. The distribution patterns of their susceptibility to Hg, Cd and As clearly revealed two peaks, but only a single peak of resistance to Pb. It can be seen that resistance was demonstrable in media containing the following concentrations of the metals (micrograms/ml): HgCl2, 10; CdCl2, 400; and Na2HAsO4, 400. In K. pneumoniae, the frequency fo resistance to these concentrations of Hg, Cd and As were 65,8%, 98,3% and 83,8%, respectively. On the other hand, the frequency to antibiotic resistance of K. pneumoniae were 68,1% of SM, 51,2% of TC, 49,7% of CP and 36,7% of KM. Furthermore, many isolates (99,6%) were metal-resistant. Most of these metal-reisitant strains were multiple-metal-resistant and also multiple-drug-resistance. And about 30% of total isolates were metal-resistant but drug-sensitive, whereas the frequency of the metal-sensitive and drug-resistant strains was 0%.

Anti-Bacterial Agents↗
PubMed1977

Mercury resistance and R plasmids in Escherichia coli isolated from clinical lesions in Japan.

The mercury and antibiotic resistance of 338 strains of Escherichia coli isolated from hospital patients was determined. Resistance to mercury was found in 58.6% of the isolates. The frequencies of resistance to streptomycin (Sm), tetracycline (Tc), chloramphenicol (Cm), kanamycin (Kan), cephaloridine (Cer), and gentamicin (Gm) were 66.3, 60.3, 56.5, 42.9, 32.1, and 1.5%, respectively. Among the above, 198 mercury- and antibiotic-resistant isolates were selected and tested for their ability to transfer the resistance to susceptible strains of E. coli K-12 and Klebsiella pneumoniae JK5. R plasmids carrying mercury resistance were demonstrated in 89.9% of the mercury-resistant strains of E. coli. Furthermore, R(Hg,Sm,Tc,Cm) plasmids were demonstrated most frequently, followed by R(Hg,Sm,Tc,Cm,Kan), R(Hg,Cm,Kan), and R(Hg,Sm,Tc,Cm,Kan,Cer) plasmids.

Anti-Bacterial Agents↗
PubMed1977

Serotype B staphylococcal bacteriophage singly converting staphylokinase.

A new staphylococcal phage, Pphi-2, which could convert the capability of producing staphylokinase, was isolated. The phage is different from the phage reported by Winkler and co-workers [Nature(London) 195:407-408, 1962; J. Gen. Microbiol. 39:321-333, 1965]. The former is a single-converting phage belonging to serotype B, but the latter is a serotype F phage capable of converting not only staphylokinase but also beta-hemolysin. Staphylokinase, i.e., the fibrinolysin produced by Staphylococcus aureus, therefore, can now be classified into three types. One is controlled by the genes on the bacterial chromosome, and the other two are mediated by lysogenic conversion by prophage Pphi-2 and the classical phage reported by Winkler and co-workers.

Fibrinolysin↗
PubMed1977

Immunological properties in staphylococcal toxic epidermal necrolysis.

The analysis of host defenses in 4 patients with staphylococcal toxic epidermal necrolysis revealed normal serum immunoglobulin levels, but a deficiency in cell-mediated immunity as detected by the tuberculin reactions. We suspected that the transient deficiency of cell-mediated immunity may have contributed to the development of this disease.

Child↗