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Biomedical subjects

I Kondo

Publications and source records attributed to I Kondo.

At least 271 records · Page 15Linked to original sources
PubMed1981

Clinical evaluation of intraoperative radiotherapy for carcinoma of the urinary bladder.

Intraoperative radiotherapy using one shot high dose electron irradiation was performed for 116 bladder cancer patients as a radical means of treatment for superficial bladder cancer. Additional fractionated external supervoltage irradiation covering the whole bladder was given in most of the cases. The one-, three-, and five-year survival rates were 100%, 100%, and 96.3% for T1 cases and 100%, 87.2%, and 61.6% for T2 cases, respectively. Heterotropic recurrences in the bladder were 5.3% within one year, 9.4% within two years, and 19.3% within five years, respectively. Normal vesical function was well preserved except in five patients who underwent total cystectomy subsequently because of multiple recurrences after radiotherapy and one patient who underwent urinary diversion because of contracted bladder and progressive bilateral hydronephrosis. Intraoperative radiotherapy was established as a reliable and superior method for the treatment of superficial bladder cancer because of the low recurrence rate and good preservation of vesical functions after treatment.

Adult↗
PubMed1981

The bovine genes for phosphoglycerate kinase, glucose-6-phosphate dehydrogenase, alpha-galactosidase, and hypoxanthine phosphoribosyltransferase are linked to the X chromosome in cattle-mouse cell hybrids.

Bovine embryonic trachea cells were hybridized with mouse A9 cells deficient in hypoxanthine phosphoribosyltransferase, and cattle-mouse hybrid cells clones were isolated after HAT/ouabain selection. In these interspecific cell hybrids, bovine glucose-6-phosphate dehydrogenase, alpha-galactosidase, and phosphoglycerate kinase were expressed concordantly with bovine HPRT. Their expression depended on the presence of bovine X chromosome. These data indicated that the genes for G6PD, PGK, and HPRT are linked and can be assigned to the bovine X chromosome.

Animals↗
PubMed1980

Prominent increase in the amount of a cytosol protein in transformed fibroblasts and ascites hepatoma cells.

Analysis of cytosol proteins by sodium dodecyl sulfate polyacrylamide slab gel electrophoresis revealed a prominent increase in the amount of a cytosol protein with molecular weight of 88 000 in transformed human adult, human embryo, mouse adult, and hamster embryo fibroblasts as compared with normal fibroblasts. The cytosol protein with Mr 88 000 is also increased in the cytosol of four kinds of rat ascites hepatoma cell as compared to normal and regenerating liver. The protein with Mr 88 000 exists as one of the major cytosol proteins in transformed fibroblasts hepatoma cells and HeLa cells, constituting 7--10% of total cytosol proteins. The data suggest that the cytosol protein with Mr 88 000 is associated with certain growth characteristics of cells.

Adult↗
PubMed1980

A cytogenetic survey of 449 patients in a Japanese institution for the mentally retarded.

A cytogenetic survey was carried out on 449 patients (261 males and 188 females) in an institution for the mentally retarded in Japan. A total of 37 patients (8.1%) were shown to have chromosome abnormalities. There were 33 individuals (7.3%) with 21 trisomy. In addition, we found one patient with 46,XY/47,XY,+12p, one with 46,XY,r(22), and one with 45,XY,-13,-14,+t(13q14q). Only one female was found to have an abnormal sex chromosome constitution, 47,XXX. The significant contribution of chromosome abnormalities in the etiology of mental retardation is also shown in the present survey. The most common chromosome abnormality was 21 trisomy, as seen in other similar surveys.

Adolescent↗