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Biomedical subjects

I Katayama

Publications and source records attributed to I Katayama.

At least 361 records · Page 20Linked to original sources
PubMed1980

Significance of leukocyte alkaline phosphatase in hairy cell leukemia.

Peripheral blood samples of 23 patients who had hairy cell leukemia were examined for leukocyte alkaline phosphatase scores. Leukocyte alkaline phosphatase levels were elevated in seventeen patients (74%), were normal in six (26%), and were not decreased in any patient. The mean leukocyte alkaline phosphatase score was 166 (normal range, 11-95). High leukocyte alkaline phosphatase scores correlated inversely with the absolute number of neutrophils in peripheral blood and were unrelated to other clinical factors, including age and time since splenectomy. High leukocyte alkaline phosphatase scores were also associated with a shift to more immature forms of neutrophil differentiation. These findings are consistent with the view that high leukocyte alkaline phosphatase levels in hairy cell leukemia are secondary to decreased marrow granulocyte reserves and do not necessarily indicate the existence of primary abnormalities of multiple bone marrow cell lines, including the granulocytes, in hairy cell leukemia. The role of the leukocyte alkaline phosphatase assay in the differential diagnosis of hairy cell leukemia with respect to non-Hodgkin's lymphoma, chronic lymphocytic leukemia, and other lymphoid malignancies is discussed.

Adult↗
PubMed1980

B-lineage prolymphocytic leukemia as a distinct clinicopathologic entity.

Prolymphocytic leukemia (PLL) was described originally by Galton and his colleagues as a special variant of chronic lymphocytic leukemia (CLL) with distinct clinical and hematologic features. Subsequent authors have described considerable heterogeneity in the clinical and immunologic features of PLL but have not dealt in detail with pathologic descriptions of their cases. Consequently, one might question whether PLL represents one disorder or a heterogeneous group of disorders. Three patients who satisfied Galton's original diagnostic criteria for PLL were examined by pathologic and immunologic methods. The spleens of these patients showed distinctive pseudonodular pathologic features. The malignant prolymphocytes were characterized as B-lineage by the presence of surface IgM and IgD, the expression of HLA-DR antigen, the absence of E-rosette formation, and the absence of natural killer cell activity. The existence of B-lineage prolymphocytic leukemia is affirmed as a distinct entity with unique pathologic, clinical, and immunobiologic characteristics.

Aged↗
PubMed1979

Internal synthesis of p23,30 by several lymphoid malignancies.

The aim of this study was to prove the internal synthesis of p23,30 antigen (HLA-D related determinant) on human leukemias and lymphomas on which it has been detected with complement-dependent cytotoxic assays. Murine Ia antigens similar to p23,30 antigen are found on many subsets of cells in the mouse (B lymphocytes, macrophages, allogeneically activated T lymphocytes) and on intercellularly transferred immunoregulatory molecules, which may be adsorbed to other cells. The question exists whether the p23,30 antigen, which occurs on a wide range of human leukemias, is internally synthesized by these tumors or, in some instances, is synthesized by normal lymphocytes and is adsorbed to the leukemic cells. The expression of p23,30 antigen on a limited series of human leukemias and lymphomas was detected by a complement dependent, cytotoxicity assay. The internal synthesis of p23,30 antigen and p44,12 (HLA-A and -B antigens and beta2-microglobulin) was confirmed by immunoprecipitation and these antigens from [35S]methionine labeled, detergent solubilized membranes of tumor cells. In each instance, the synthesis of p23,30 antigen by the malignant cells was confirmed. The distribution of p23,30 antigen (and 1a antigen) on subsets of normal cells and in immunoregulatory molecules was reviewed. In view of these findings, the role of p23,30 antigen in the diagnosis of subsets of human hematologic malignancies was reconsidered.

Antigens, Surface↗
PubMed1978

Leukemic reticuloendotheliosis: report of a case with peripheral blood remission on androgen therapy.

Leukemic reticuloendotheliosis (LRE) has been generally considered to be poorly responsive to therapy other than splenectomy. The patient presented below developed a complete peripheral blood remission after prolonged therapy with an androgen (oxymetholone). There is very little published experience with androgen therapy in LRE. The experience with this patient suggests that androgens may produce a clinical remission by inducing significant improvement in the peripheral blood in some patients with this disease.

Adult↗
PubMed1978

Angiogenic activity in culture supernatant of antigen-stimulated lymph node cells.

The culture supernatant of antigen- and phytohaemagglutinin-stimulated lymph node cells contained angiogenic activity when applied to hamster cheek pouch vascular membranes. New capillary growth was observed about 7 days after such application. This activity was generated by culturing lymph node cells with antigens for at least 12 hr, while migration inhibitory factor (MIF) was detected in the culture supernatant of 6 hr cultures. The angiogenic activity was separated from blastogenic activity, clot-promoting activity and antibody activity. However, it was not completely separated from MIF by gel-filtration. The molecular weight of the angiogenic activity was estimated to be between 35,000 and 55,000 daltons.

Angiogenesis Inducing Agents↗