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I Katayama

Publications and source records attributed to I Katayama.

At least 343 records · Page 19Linked to original sources
PubMed1982

Non-Hodgkin's lymphomas. analysis of 109 Japanese cases with the use of LSGJ classification.

Recently the Lymphoma Study Group of Japan (LSGJ) proposed a new classification of non-Hodgkin's lymphomas (NHLs), diving NHLs into the follicular group consisting of three subsets and the diffuse group, 7. Each subset of the diffuse group is further divided into B or T cell types according to immunologic markers and/or morphologic prediction. In the review of 118 malignant lymphomas, the authors studied the 109 cases of NHLs, attempting to assess the clinicopathologic utility of this classification. Morphologic criteria, enzyme histochemistry, and immunoperoxidase technique were used to ensure the accuracy of the immunologic phenotyping. The results suggest that the LSGJ classification is easily reproducible and yields a more precise clinicopathologic correlation than traditional, morphologic classifications. Consistent with similar studies in Japan, this study demonstrated a low incidence of Hodgkin's disease (7.6% of all lymphomas) and follicular lymphomas (8.3% of all NHLs) and a high incidence of T cell lymphomas (34.9% of all NHLs). The incidence (45.9%) of extranodal presentation was high. These four features seem characteristic of lymphomas in Japan.

Adolescent↗
PubMed1981

Differences in synthesis of membrane proteins by leukemic cells from spleen and peripheral blood indicate distinct subsets of malignant cells in a patient with prolymphocytic leukemia.

Morphological and biochemical differences were demonstrated between prolymphocytic leukemia cells obtained from the spleen and peripheral blood of one patient. Peripheral blood prolymphocytes had consistently smaller nuclear-cytoplasmic ratios than did splenic prolymphocytes. Percoll gradient-purified prolymphocytes from the spleen synthesized abundant amounts of some membrane proteins which were hardly expressed by peripheral blood prolymphocytes. Peripheral blood prolymphocytes did not change their expression of membrane proteins during three days in culture. These findings are consistent with the view that prolymphocytic leukemia cells from the spleen exist, on the average, at an earlier stage of differentiation than do circulating leukemic cells, and that peripheral blood leukemic cells are frozen at a specific phase of differentiation.

Aged↗
PubMed1981

Antibodies to Epstein-Barr virus-specific antigens in patients with hairy-cell leukemia.

Antibody titers to Epstein-Barr virus (EBV)-specific antigens of 19 patients with hairy-cell leukemia (HCL) were markedly elevated. All patients showed high titers of IgG anti-viral capsid antigen (VCA) reactivity equal to or greater than 320 (reciprocal titer). The anti-VCA reciprocal geometric mean titer (GTM) was 1106 in contrast to a GMT of 80 for healthy controls (p less than 0.001). No IgM anti-VCA antibody was detected, but three patients had IgA anti-VCA antibodies. Fourteen patients had elevated anti-early antigen (EA) titers (GMT = 177) which were indicative of active infections with EBV. Seven of the 14 patients demonstrated the diffuse component antibody of the early antigen (EA) complex at a GMT of 98. Anti-Epstein-Barr virus nuclear antigen (EBNA) was detected in sera of 16 patients (GMT = 64, controls GMT = 79). It is noteworthy that three patients with anti-VCA titers lacked anti-EBNA titers. These anti-body responses suggest that immunodeficiency secondary to HCL allowed reactivation of the virus.

Adult↗
PubMed1981

Suppression of contact sensitivity by IgG1 antihapten antibody in contact-sensitized guinea pigs.

The guinea pig sera obtained 2 weeks after 1-fluoro-2,4-dinitrobenzene sensitization had ability to suppress elicitation of contact sensitivity when transferred intravenously into contact sensitized guinea pigs. The activity was found only in the sera obtained 2 weeks after the sensitization, whereas the sera obtained 1 and 3 weeks after the sensitization had no effect on contact sensitivity. Pretreatment of cyclophosphamide abolished the generation of the suppressive factor. The suppressive factor was hapten-specific. It was eluted from a Sephadex G-150 column into 7S gamma-globulin fraction and from DEAE ion exchange cellulose column into IgG1 fraction. The suppressive activity was absorbed on a dinitrophenylated bovine gamma globulin Sepharose 4B column and was eluted by either acidic buffered solution or dinitrophenol from the affinity column. It was absorbed by antiguinea pig IgG1-Sepharose and not by antiguinea pig IgG2-Sepharose, Therefore, the suppressive activity found in the sera of 1-fluoro-2, 4-dinitrobenzene sensitized guinea pigs was attributed to IgG1 antihapten antibody.

Animals↗
PubMed1981

Subacute necrotizing lymphadenitis --a clinicopathologic study.

This report describes the clinical and pathologic findings of 21 patients with subacute necrotizing lymphadenitis (N.L.). Clinical features of all but 2 patients were as typically described in the literature; young age, enlargement of cervical or axillary lymph nodes, slight to moderate fever with poor response to antibiotics, and invariable spontaneous resolution. Two patients showed atypical clinical findings; remittent high fever with profound prostration in both patients, generalized lymphadenopathy in one, and being a Caucasian in the other. Systemic symptoms resolved gradually, and both patients are now doing well. One patient, however, underwent a staging laparotomy due to a misdiagnosis as unclassifiable lymphoma of the lymph node biopsy. Biopsies of the lymph nodes from all patients demonstrated the typical pathologic features of N.L.; i.e., an intensive proliferation of leukocytes were characteristically absent. Bacteriologic and serological studies were negative. We conclude that some patients with N.L. run a protracted course with remittent high fever before spontaneous resolution and that a correct pathologic diagnosis helps precluding unnecessary diagnostic or therapeutic measures on such patients.U

Adolescent↗
PubMed1981

Enzyme histochemistry on paraffin embedded tissue sections.

To obtain diagnostic enzyme reactions in paraffin embedded tissue sections, we compared four fixatives (buffered formol sucrose, Baker's formol calcium, periodate lysin paraformaldehyde, and buffered formalin acetone) and subsequent acetone dehydration with or without graded concentrations of Triton X-100. Four spleens and 14 lymph nodes were tested for peroxidase, naphthol ASD chloroacetate esterase, acid phosphatase, alpha naphthyl acetate esterase, and alpha naphthyl butyrate. Best results were obtained by a processing method using buffered formalin acetone, Holt's gum sucrose, dehydration in acetone with 0.03% Triton X-100, and paraffin for embedding.

Histocytochemistry↗