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Biomedical subjects

I Katayama

Publications and source records attributed to I Katayama.

At least 379 records · Page 21Linked to original sources
PubMed1977

Histiocytic lymphoma with sclerosis arising from a nodular lymphoma with a special stromal reaction.

Histiocytic lymphoma with sclerosis was found together with a small nodular lymphoma in a cervical lymph node biopsy from a 48-year-old man. Since the cellular origin of this entity is unclear and its ultrastructure has not been described before, we processed formalin-fixed samples for electron microscopy, which revealed three cell types: small lymphocytes with cleaved nuclei, large lymphocytes with vesticular noncleaved nuclei, and mesenchymal stromal cells occasionally bearing desmosomes or hemidesmosomes. In addition, there was an increase of the intercellular connective tissue, which consisted of a mixture of normal and fibrous long spacing collagen fibers. The results indicate that histiocytic lymphoma with sclerosis can evolve from a nodular lymphoma, and that diagnostic information can be obtained by electron microscopy of tissue samples previously fixed in formalin.

Connective Tissue↗
PubMed1977

Reassessment of a cytochemical test for differential diagnosis of leukemic reticuloendotheliosis.

Reports of negative tartrate-resistant acid phosphatase reactions in a few cases of leukemic reticuloendotheliosis prompted the authors to re-evaluate the diagnostic specificity of this test. As a result, they modified the test by (1) incorporating a dual-control system for excluding a false-negative test due to technical errors, and (2) instituting an objective grading system for assuring consistent interpretation of the test on blood smears. When these modifications were applied to materials of patients suspected to have leukemic reticuloendotheliosis, there was an excellent, although not specific, correlation between the positive test and the diagnosis of leukemic reticuloendotheliosis. Tartrate-resistant acid phosphatase reactions were positive, intermediate, and negative for 76, 21, and 3% of 29 patients who had leukemic reticuloendotheliosis, whereas the figures were 3, 32, and 65%, respectively, for 37 patients who had chronic lymphocytic leukemia and other hematologic disorders.

Acid Phosphatase↗
PubMed1977

Further ultrastructural characterization of hairy cells of leukemic reticuloendotheliosis.

Studies with transmission and scanning electron microscopes (TEM and SEM) were performed on specimens from patients suspected of leukemic reticuloendotheliosis (LRE), irrespective of the final diagnoses. The blood samples were fixed immediately in order to avoid in vitro changes of leukocytes. Leukemic reticuloendotheliosis cells demonstrated numerous long microvilli and pseudopods, whereas the immediately fixed lymphocytes demonstrated fewer, shorter microvilli and no pseudopods. These surface features distinguishing LRE cells from lymphocytes and monocytes were appreciated by both SEM and TEM. In addition, TEM revealed significant differences in the incidence of certain ultrastructural alterations. Whereas nuclear pockets were rare in lre cells, they were relatively frequent in lymphocytes of other hematologic disorders. The inclusions of ribosome-lamella complexes were not only more prevalent in patients with LRE but were seen in a higher percentage of leukemic cells from patients with LRE than in those from patients with other hematologic disorders. Electron microscopy can play a role in the laboratory diagnosis of LRE.

Bone Marrow↗
PubMed1976

The heterogeneity of leukemic reticuloendotheliosis, "hairy cell leukemia". Evidence for its monocytic origin.

The presence of B, T, and monocyte markers were studied on the spleen and peripheral blood mononuclear cells from two patients with leukemic reticuloendotheliosis. A high proportion of cells from both patients bore a receptor for cytophilic antibody, both in suspension and frozen tissue section. Cells in suspension lacked surface immunoglobulins or a receptor for sheep red blood cells. These results favor the evidence that "hairy cells" are monocytic in origin.

Animals↗
PubMed1975

The platelet in leukemic reticuloendotheliosis. Functional and morphological evidence of a qualitative disorder.

Platelets were studied in a group of 10 patients with typical clinical course, morphological findings, and specific histochemical criteria for leukemic reticuloendotheliosis. In 8 of these, marked qualitative abnormalities were found. These included lack of aggregation following epinephrine stimulation (6 patients), and decreased platelet factor 3 availability following ADP stimulation (4 patients). In addition, platelets in 4 of the 10 patients were studied by electron microscopy. All had granular abnormality, and 1 case showed the presence of rough-surfaced endoplasmic reticulum. The functional and ultrastructural abnormalities of platelets reported here may be responsible for the clinically important bleeding episodes which were not attributable to thrombocytopenia in 2 of our patients. The findings also provide a clue to the basic nature of this histogenetically controversial malignancy.

Adenosine Diphosphate↗