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Biomedical subjects

I Honjo

Publications and source records attributed to I Honjo.

At least 145 records · Page 8Linked to original sources

Significance of levator muscle sling formation in cleft palate surgery: evaluation by electrical stimulation.

The effect of levator muscle sling formation in cleft palate surgery was evaluated by electrical stimulation of the muscle at surgery. Palatal movement before and after sling formation was recorded through a force transducer. After muscle sling formation, the soft palate was elevated more effectively toward the retropharynx and its mobility increased remarkably. The surgical procedure, which had been proposed on the basis of anatomic considerations, was proved to be effective for improving velopharyngeal function.

Cleft Palate↗

Electromyographic study of patients with dysfunction of the Eustachian tube.

In order to determine how often dysfunction of the tube might arise from dysfunction of the tubal muscles, electromyographic examination of the muscles was carried out on 34 patients with occluded or patent tube. Using a monopolar needle electrode inserted through the nose, selective EMG of the tensor and levator veli palatini muscles were picked up during swallowing. It was found that the patients showed neither abnormally reduced nor increased muscle activity. Comparison of muscle activity of the normal tube and of both the occluded and patent tube revealed no significant differences. Therefore, myogenic cause of tubal dysfunction seems improbable from the clinical viewpoint.

Electromyography↗

Role of the tensor veli palatini muscle in movement of the soft palate.

To examine the role of the tensor veli palatini muscle in palatal movement, we conducted 1) quantitative measurement of palatal movement by selective stimulation of the tensor and levator muscles, and 2) EMG recording of the two muscles during phonation. The results were: 1) negligible palatal movement upon tensor stimulation, despite a marked velar elevation by levator stimulation; and 2) little EMG activity of the tensor and marked EMG activity of the levator during phonation. It was concluded that the tensor plays no role in the palatal function.

Animals↗

In vitro actions of some antibiotics on phospholipases.

The effects of some antibiotics on activities of phospholipase A2, B and C were investigated in vitro. Tetracyclines, macrolides, chloramphenicol and carbenicillin inhibited the activity of Crotalus adamanteus phospholipase A2 towards phospholipids of egg-yolk emulsions. When the ability to inhibit the activity of Penicillium notatum phospholipase B towards mixed micelles of phosphatidylcholine and Triton X-100 was investigated, polymyxin B was found to be inhibitory while chloramphenicol and carbenicillin were found to stimulate the activity of the phospholipase. The activity of Bacillus cereus phospholipase C towards the mixed micelles was inhibited by bleomycin, oleandomycin and chloramphenicol.

Carbenicillin↗

Reexamination of the acoustic method in measurement of Eustachian tube function.

In order to assess the reliability of the acoustic method in examination of Eustachian tube function, 30 subjects with normal, obstructive or patent tubes were examined twice, by the acoustic method, and by the aerodynamic method which we have developed. The reliability of the aerodynamic method has been confirmed by repeated clinical examinations. 60% of the results of the acoustic method were found to disagree with both the results of the aerodynamic method and the clinical findings of the tested ears. One cause of this disagreement was shown to be the influence of motion accompanying deglutition upon the sound transmission.

Acoustic Stimulation↗

Aerodynamic pattern of Eustachian tube dysfunction.

Detailed aerodynamic patterns for various disorders of the Eustachian tube function were reported. Simultaneous recording of the pressure in the ear canal and the pharyngeal cavity during Valsalva's maneuver and deglutition permitted an objective evaluation of different tubal dysfunctions. The patient with occluded tube showed either disturbance of the air flowing into the tube or outflowing from the tympanum to the pharynx. Depending on the degree of patency, the patulous tube showed either a synchronous change of the tympanal pressure with that of the pharyngeal cavity or an early and sudden drop of the tympanal pressure without deglutition. Through this rather simple aerodynamic technique, evaluation of different tubal dysfunction is possible.

Adult↗

Changes after major resection of experimental cirrhotic liver.

Liver cirrhosis was induced experimentally in dogs--hemodynamically, by constriction of the hepatic vein and pharmacologically, by administration of dimethylinitrosamine (DMNA)--after which approximately 45 per cent of the liver was resected. Results indicate that death after major resection of a cirrhotic liver was caused not only by too extensive a resection but also by the rapid progression of cirrhotic changes in the remnant liver during the postoperative course.

Animals↗

Congenital cystic dilatation of the common bile duct as a cause of primary bile duct stone.

Of the 101 patients with congenital cystic dilatation of the common bile duct, eighty-eight with adult-type cysts are reported on. The association of primary bile duct stone and adult-type cyst of this anomaly is discussed and found to be higher than previously recognized. In the cases without calculi, abnormal arrangement of the pancreaticobiliary ductal system is indicated to play an important role in the manifestation of the symptom. The anatomic and clinical features and the results of treatment for this type of cyst are reviewed.

Adult↗

Clinicopathologic classification of congenital cystic dilatation of the common bile duct.

From 1970 to 1975, 103 patients with a localized dilatation of the biliary passages were treated at the First Department of Surgery of Kyoto University Medical Center. Of the 103, 101 had congenital cystic dilatation of the common bile duct (Alonso-Lej type I). These dilatations were classified into two sub-types, "infant type" and "adult type," based on the anatomic location and clinical features. Infant type cyst was typically large cyst of the choledochus and most common in infancy and childhood. Adult type cyst was fusiform dilatation of the biliary tract, and most common in adults. Gallstones were seen in most of the patients with this type cyst.

Adolescent↗