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Biomedical subjects

I Fukuda

Publications and source records attributed to I Fukuda.

At least 163 records · Page 9Linked to original sources
PubMed1986

Two-dimensional echocardiographic evaluation of the severity of mitral stenosis with reference to the prediction for mitral valve commissurotomy or replacement.

Thirty patients with mitral stenosis were classified into three grades of severity reflected by anterior mitral leaflet and subvalvular apparatus using two-dimensional echocardiography in order to study the possibility of predicting the type of surgery indicated, and were evaluated pre- and postoperatively for systolic and diastolic volumes; left heart function using left ventricular posterior wall movement (LVPWVSmax, LVPWVdmax) and posterior wall excursion (PWE) and newly devised left atrial empty volume ratio (LAEVR). The LVPWVSmax was increased from 57 +/- 7 to 74 +/- 7 mm/s (p less than 0.001) in grade I, from 48 +/- 13 to 63 +/- 9 mm/s (p less than 0.02) in grade II, and from 44 +/- 6 to 64 +/- 7 mm/s (p less than 0.001) in grade III. The LVPWVdmax showed an increase from 68 +/- 15 to 91 +/- 15 mm/s (p less than 0.001) in grade I, from 57 +/- 17 to 86 +/- 18 mm/s (p less than 0.01) in grade II, and from 55 +/- 11 to 83 +/- 6 mm/s (p less than 0.01) in grade III. In the PWE, there was an improvement from 12.4 +/- 1.6 to 15.5 +/- 2.1 mm (p less than 0.01) in grade I; from 10.5 +/- 2.0 to 12.5 +/- 1.5 mm (p less than 0.02) in grade II; and from 9.4 +/- 1.5 to 14.4 +/- 1.5 mm (p less than 0.001) in grade III. In the LAEVR, there was also an improvement from 65 +/- 12 to 39 +/- 21% (p less than 0.01) in grade I.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1986

Stability of endotoxin detected in human plasma against endotoxin-inactivating factor (EIF): quantitative analysis of EIF using chromogenic endotoxin assay.

Using a quantitative blood endotoxin assay utilizing chromogenic substrate coupled with perchloric acid pretreatment (PCA-LCT), we showed the presence of endotoxin-inactivating factor (EIF) in human plasma in vitro. EIF activity inactivated added endotoxin to about 10(-4) of the initial level within 20 min, followed by a stable phase where the residual endotoxin became resistant to EIF and was not further inactivated. The residual endotoxin may represent the endotoxin in patient plasma which is also EIF resistant. We postulate that endotoxin, upon entering the blood, is rapidly inactivated by chemical modification of its active site, lipid A, through EIF. Subsequently, inactivated endotoxin, mainly consisting of polysaccharide, is gradually removed from circulation by endocytosis in the reticuloendothelial system.

Chromogenic Compounds↗
PubMed1985

Endotoxemia in liver diseases: detection by a quantitative assay using chromogenic substrate with perchloric acid pretreatment.

With a quantitative blood endotoxin assay using a chromogenic substrate with a perchloric acid pretreatment (PCA-LCT), endotoxemia in various liver diseases was studied. With PCA-LCT, recovery of added endotoxin in human plasma was nearly 90%, as evidenced by an intra- and inter-assay coefficients of variation of 5.7% and 11%, respectively. Because the recovery of endotoxin was not affected in severely icteric plasmas, PCA-LCT proved to be applicable to patients with liver diseases where various degree of jaundice exist. In none of the plasmas from patients with chronic hepatitis, acute hepatitis without hepatic failure or liver cirrhosis without ascites did the endotoxin level exceed the normal range of less than 5 pg/ml. With the presence of ascites, however, endotoxemia became detectable, but at low levels and not in all cases. At the stage of hepatic failure complicated with renal failure or disseminated intravascular coagulation, endotoxemia was more frequent and endotoxin concentration greater. It is uncertain, at present, whether endotoxemia itself is deteriorating factor in hepatic failure or is merely concomitant phenomenon resulting from Kupffer cell failure.

Ascites↗
PubMed1985

[Studies on the surgical therapy of early gastric cancers].

Surgical treatment were performed for 1190 patients with early gastric cancer at the Center for Adult Diseases, Osaka, during these 20 years. We studied on the following three clinical problems in surgical therapies for early gastric cancer; appropriate margin to resect the stomach, lymph node dissection and adjuvant chemotherapy. It is important to resect the stomach to allow an enough surgical margin, because of multiple foci and ill-defined lesion. During surgical operation special attention should be paid to multiple foci or unexpected extension of the lesion. As to lymph node dissection, N1 and N2 lymph nodes have to be removed but in elevated type lesions invading within mucosal layer, the dissection of N1 only can be permitted. Early gastric cancer patients with lymph nodes metastases had less favorable survival after surgical operation, indicating the necessity of adjuvant chemotherapy.

Humans↗
PubMed1984

[Clinico-pathological study on the appropriate range of pancreatic resection to obtain operative curability of pancreatic head cancer].

We studied the mode of spread on the pancreatic head carcinoma histologically in association with the patient survival period and the mode of cancer recurrence. The histological materials were 41 surgically resected specimens and 12 autopsied specimens. The mode of cancer spread were classified into 5 factors: continuous spreading along the caudal pancreatic duct wall; dysplastic lesion; multicentric cancer lesion; lymphatic infiltration; lymph node metastasis and direct invasion toward the retroperitoneal space. As a result, total pancreatectomy is considered as rationale only when continuous ductal infiltration spreads into the duct in pancreatic tail, but the cut margin of the pancreas should be 2 cm distant, at least, by the macroscopical observation. Additionally, frozen section of the cut line, cytological examinations of the pancreatic juice and duct epithelium in remaining pancreas should be negative. It was remarkable that the patient's prognosis depended upon the lymph-node involvement and retroperitoneal invasion at the surgical resection. Therefore, it is most important to do prophylactic resection of a soft tissue behind the pancreas including lymph nodes in the retroperitoneal space.

Adenocarcinoma, Papillary↗
PubMed1984

[pm Gastric cancer and modes of invasion to the pm layer].

Two hundred and eighty-eight cases of gastric cancer, whose deepest layer of cancerous invasion was the tela muscularis propria (pm), were divided into the following 4 types according to modes of invasion to the pm layer: 1) minimal invasion type (45 cases, 16%); 2) localized invasion type (128 cases, 44%); 3) diffuse invasion type (98 cases, 34%), and 4) vascular invasion type (17 cases, 6%). This classification of modes of invasion to the pm layer was useful and reflected the gross findings of cancer, grade of vascular invasion and prognosis quite well.

Adult↗