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Biomedical subjects

I Fukuda

Publications and source records attributed to I Fukuda.

At least 145 records · Page 8Linked to original sources
PubMed1988

Computed tomographic diagnosis of enterovesical fistulae: barium evacuation method.

We reviewed and compared the computed tomographic (CT) findings for 5 patients suspected of having enterovesical fistulae with convential radiographic studies and the results of cystoscopy. Prior to scanning, patients were rectally administered 200 ml of 0.8% wt/vol barium solution, and then evacuated before they were administered 200 ml of olive oil via the anus and 100 ml of olive oil via the urethra. The CT following the barium evacuation successfully demonstrated the enterovesical fistulae in 4 patients. It was also diagnostic in a clinically suspected case in verifying the absence of an enterovesical fistula.

Barium Sulfate↗
PubMed1988

Practical usefulness of lymphatic and connective tissue clearance for the carcinoma of the pancreas head.

We performed a retrospective review of 59 pancreatic resections for ductal carcinoma of the pancreas head performed between 1971 and 1983. In addition to pancreaticoduodenectomy, 37 consecutive patients (from 1971 to 1981) received lymphatic dissection adjacent to the pancreatic head (Group R1), whereas another 22 patients (from 1981 to 1983) received a wider range of lymphatic and soft tissue dissection, including the para-aortic region (Group R2). These groups did not differ with regard to operative mortality rate or background factors in the patients who tolerated operation. The 3-year cumulative survival rate was 13% in the R1 group vs. 38% in the R2 group (p less than 0.05). Almost all of the deaths from cancer recurrence occurred within 3 years after operation; the cumulative rate of death from local recurrence decreased from 67 to 16% (p less than 0.05) at 3 years. Among the patients with nodal involvement, there was no 3-year survivor in the R1 group, but four (27%) in the R2 group (p less than 0.05) survived. Among the patients whose tumor size exceeded 4 cm with retroperitoneal invasion, there was no 3-year survivor in either group and most patients died of distant metastasis. Extended clearance of regional lymph nodes and soft tissue appears to benefit patients with ductal carcinoma of the pancreatic head whose tumor size is less than 4 cm without severe invasion to the retroperitoneal space.

Carcinoma, Intraductal, Noninfiltrating↗
PubMed1988

[Transcatheter arterial chemoembolization in liver metastases of colorectal cancer (lipiodol cisplatin sandwich therapy].

The transcatheter arterial chemoembolization (LPD-CDDP Sandwich Therapy) developed by us was applied to 15 patients with unresectable liver metastases (H2-H3) of colorectal cancer. Computed tomography or ultra-sonography revealed an overall response rate of 27%. Serum CEA values decreased to lower than the pre-TACE value in 11 (78%) of 14 patients excluding one showing the normal range before TACE. The post-TACE CEA values were completely normalized in 2 of the 11 patients. One-year cumulative survival rate was 72% and median survival was 18 months, showing a prolongation compared with intraarterial or systemic chemo-immunotherapy. The histological antitumor effect of LPD-CDDP Sandwich Therapy was examined in the hepatic specimens from 6 patients who underwent hepatectomy after this therapy for liver metastases (H1-H2) of colo-rectal cancer. The necrotic area in the main tumor was 95-100% in 3 patients, 75-94% in 2 patients and 50-74% in one patient. LPD-CDDP sandwich therapy was considered an effective treatment without any serious side effects for liver metastases of colo-rectal cancer.

Cisplatin↗
PubMed1988

[Effectiveness of preoperative transcatheter arterial embolization for improved survival rates in patients with hepatocellular carcinomas (sandwich therapy using ethiodized oil, cisplatin and gelatin sponge].

The effect of hepatic transcatheter arterial embolization (TAE) therapy was evaluated in 153 patients with hepatocellular carcinomas who underwent radical hepatectomy. They were divided into 3 groups. Group A (n = 56) received preoperative TAE using ethiodized oil, cisplatin and gelatin sponge (sandwich therapy). Group B (n = 29) received preoperative TAE using adriamycin + gelatin sponge, ethiodized oil + adriamycin + gelatin sponge or adriamycin + degradable starch microsphere. Group C (n = 68) did not receive TAE preoperatively. The 3-year disease-free survival rates in Group A, B, and C were 56%, 34% and 32%, respectively. The rate was significantly higher in Group A than Group C (p less than 0.05). The 1-year disease-free survival rates after partial hepatectomy were 89% in Group A (n = 22), 53% in Group B (n = 15) and 67% in Group C (n = 22). The 3-year survival rate of these patients in Group A was significantly higher (95%), compared to Group C (70%) (p less than 0.05). Preoperative TAE using ethiodized oil, cisplatin and gelatin sponge (sandwich therapy) was considered a useful therapy for improvement of disease-free survival rates or survival rates after hepatectomy in patients with hepatocellular carcinomas.

Aged↗
PubMed1988

[A case of colorectal cancer showing complete response to UFT].

A 33-year-old male patient underwent a low anterior resection for sigmoid colon cancer. Bloody stool developed about one month after discharge and a small, circumscribed, ulcerated adenocarcinoma was found about 1 cm anal to the site of anastomosis. After oral administration of FT 0.6 g/day for 42 days, UFT 0.6 g/day was administered successively. As a result, complete tumor response was observed within about four months. UFT 0.3 approximately 0.6 g/day has been administered daily since then. The patient has been in good health without any sign of relapse for three years after achievement of the complete response.

Adenocarcinoma↗
PubMed1988

[A clinicopathological study on conservative surgery and extended surgery for gastric cancer].

There are two problems in conservative surgery for early gastric cancer. 1) To resect the stomach at a sufficient surgical margin, brushing cytodiagnosis of the gastric mucosa and frozen section examination at the stump are performed during operation. After all these examinations, the stomach is resected at a sufficient margin because of the possibility of multifocal cancer. 2) Regarding lymph node dissection, only N1 lymph nodes are to be removed in minute cancer (less than 5mm in diameter) which have no lymph node metastasis (0%). Thirty-one cases of Borrmann type 4 gastric cancer which underwent left upper abdominal evisceration plus Appleby's method (LUAE + Apl) were compared with 31 patients who had undergone total gastrectomy with pancreatico-splenectomy (TG) before LUAE + Apl series. The 3-year survival rate in stage II-III cases was higher with LUAE + Apl (77.8%) than with TG (35.0%). There was no difference between the two groups in the incidence of postoperative complications or the function after operation. Angiography must be performed before conducting operations by LUAE + Apl preventing liver necrosis. And for patients aged over 70, we propose to reduce the procedure of LUAE + Apl.

Humans↗
PubMed1988

The organ distribution of [3H]endotoxin following partial hepatectomy.

3H-labeled endotoxin was intravenously injected into Wistar rats 24 hours following 70% hepatectomy and also into the normal rats. They were sacrificed 12 hours, 24 hours or 5 days after the injection. Microscopical autoradiography was performed on the rats' organs. The distribution of endotoxin in the organs was investigated by quantitatively measuring their radioactivity. Endotoxin was taken up mainly by Kupffer cells of the liver in all the groups. Endotoxin was observed also in macrophages of the spleen and the lung in all the groups. The amount of endotoxin per 1 g organ weight of the hepatectomized rat was significantly smaller in the liver, and significantly larger in the spleen, lung and blood (per 1 ml) than that of the control groups early after hepatectomy. These differences of the organ accumulation of endotoxin between groups diminished 5 days later. Deficient tolerance of the liver to endotoxin at the peak phase of regeneration following partial hepatectomy was suggested.

Animals↗
PubMed1988

[A staged surgical treatment of an abdominal and iliac aneurysm associated with hydronephrosis and urinoma: report of a case].

Hydronephrosis and urinoma are extremely rare complication of the abdominal aneurysm. A case of the aorto-iliac aneurysm associated with right hydronephrosis and urinoma is reported. The patient is 71 year-old female. She was admitted because of right lower abdominal pain. A diagnosis of the infrarenal abdominal aneurysm with involvement of the common iliac artery and right hydronephrosis due to ureter obstruction was made. A leakage of urine from right renal pelvis (urinoma) was also confirmed. A staged treatment for hydronephrosis was selected. At first, percutaneous nephrostomy was made under ultrasonographic guidance. Urinoma was completely disappeared thereafter. Two weeks later, the aneurysm was replaced with a Y-shaped Dacron graft and the right ureter was mobilized from the perianeurysmal fibrous tissue. On the 35th postoperative day, balloon ureteroplasty was performed through the nephrostomy catheter. Three months after operation, nephrostomy catheter was successfully withdrawn because of improved urinary passage through the right ureter. We emphasize the efficacy of staged surgical treatment combined with percutaneous nephrostomy for the abdominal aneurysm associated with hydronephrosis.

Aged↗
PubMed1988

[Local chemo-hyperthermotherapy of recurrent rectal cancer].

Local radiofrequency hyperthermia combined with chemotherapy was performed on five patients with pelvic recurrence of rectal cancer. Relief of pain was obtained in all four patients with uncontrolled pelvic pain due to recurrent rectal cancer. In some patients, CEA levels of peripheral blood were decreased and tumor necrosis was proved histologically. These results suggest that this combined therapy may be useful for patients with pelvic recurrence of rectal cancer.

Adenocarcinoma↗
PubMed1988

Fate of 3H-labeled endotoxin in partially hepatectomised rats.

Organ distribution of endotoxin was compared in normal and previously hepatectomised rats after administration of endotoxin lipopolysaccharide labeled at the galactose moiety. Most of the radioactivity was found in the liver in both cases, but total recovery was much higher in the organs of normal rats. In the liver, the amount of endotoxin per total organ and per 1 g organ weight was significantly reduced in the hepatectomised rats as compared with the intact controls. In normal rats, the radioactivity decreased 12 to 24 hours in the liver, but in the hepatectomised rats, no significant change was observed during this period. The total radioactivity in the lungs, spleen and blood (1 ml), as well as that per unit weight bases, was significantly higher in the hepatectomised rat than in normal rats. These results and autoradiographical studies suggest that endotoxin clearance activity of Kupffer cells in the liver is decreased by partial hepatectomy of the rats at the peak phase of regeneration, and that remaining endotoxin flow out of the liver is disposed mainly by the macrophages in the spleen.

Animals↗
PubMed1987

Subglottic neurofibroma in a child.

Reported here for the first time is a case of subglottic neurofibroma in an infant which was removed by laryngofissure. Neurofibromas are ubiquitous in distribution, but very rare in the larynx and also extremely rare in infancy. Only 9 cases had been reported in children under 9 years of age. In the present case, H.T., a boy aged 2 years and 7 months, complaining of inspiratory stridor since the beginning of December 1985, was admitted to our hospital on Jan. 21, 1986. The tumor was completely removed by laryngofissure and pathological diagnosis showed it to be a neurofibroma. Laryngeal neurofriboma cases are reviewed and discussed.

Child, Preschool↗