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Biomedical subjects

I Fujimoto

Publications and source records attributed to I Fujimoto.

At least 127 records · Page 7Linked to original sources
PubMed1988

[Relationship between peritoneal cytology and prognosis in endometrial carcinomas].

From 1971 to 1985, peritoneal cytologic examination was performed at the time of operation in 235 previously untreated patients with endometrial carcinoma. The relationship between the cytologic findings and prognoses by stage was investigated. The results were as follows: 1. In the peritoneal cytologic examination, 44 (18.7%) out of 235 cases were positive for cancer cells in all stages, 25 (14.5%) out of 173 cases in stage I, 7 (21.2%) out of 33 cases in stage II, and 8 (32.0%) out of 25 cases in stage III. 2. Among the 20 cases of stage I endometrial carcinoma that had no macroscopic metastasis and had positive peritoneal cytologic findings for cancer cells, 5- and 10-year cumulative survival rates were 94.7 and 94.7%, against 92.7% and 90.9% in cases with negative peritoneal cytology respectively. The recurrence rate in the same stage was 12.0% for positive cases, against 9.5% for negative cases. No significant differences between positive and negative cases were found. 3. In stages II and III, the difference between the survival rates for 9 cases which have positive peritoneal cytology without macroscopic peritoneal metastasis and 47 cases with negative peritoneal cytology were not statistically significant. 4. In endometrial carcinoma without macroscopic peritoneal metastasis, the appearance of cancer cells in peritoneal cytologic examination is not correlated with the prognosis.

Ascitic Fluid↗
PubMed1988

[Significance of preoperative diagnosis of endometrial carcinoma by angio-CT].

Angio computed tomography (CT) was performed in 87 previously untreated patients with endometrial carcinoma to study its clinical usefulness. All the patients subsequently underwent surgery and the angio CT findings were correlated with the surgical and pathologic findings. The results were as follows: 1. The tumor appeared as areas of low density in comparison with the surrounding myometrium after intraarterial infusion of contrast medium. 2. Angio CT proved to be useful in determining the depth of myometrial invasion. The myometrial invasion measured from the serosal surface in millimeters was assessed on angio CT. The CT findings were correlated well with pathologic findings. 3. Patients with intact myometrium greater than 10mm from the serosal surface assessed by angio CT had no nodal metastases. Angio CT provides a better display of cross-sectional uterine pathology than CT after intravenous infusion of contrast medium. The depth of myometrial invasion measured from the serosa on angio CT seems to be a useful prognostic factor in patients with endometrial carcinoma.

Female↗
PubMed1988

[Renal toxicity by intraperitoneal administration of CDDP].

Renal toxicity following intraperitoneal (ip) CDDP therapy after laparotomy in twenty patients with ovarian cancer was examined. Four patients had renal toxicity. Patients who received CDDP at a dose of 150 mg (2/2) had a statistically higher incidence of toxicity than those who received less than 100 mg (2/18) (p less than 0.05). Patients who underwent ip therapy on the same day as laparotomy had a statistically higher incidence of the toxicity (4/15) than those underwent it on the fourth day after (0/5) (p less than 0.05). Renal toxicity was revealed in the mean urine volume of 1,100 ml on the day of therapy, but the toxicity did not appeared in those with a mean urine volume of 2,131 ml, whose volume was statistically different (p less than 0.01). These data suggest maintenance of renal blood flow during CDDP treatment plays an important role in preventing renal toxicity even following ip therapy. By investigating preoperative laboratory data, it is seen that patients with FDP values higher than 32 micrograms/ml have a higher risk of renal toxicity.

Adult↗
PubMed1988

[Significance of total hysterectomy in uterine cervical cancer persistent in the uterine cervix after radiotherapy].

Radiation therapy is an important means for treating advanced cases of cervical cancer. There are cases, however, in which cancer cells persist even after treatment has been completed. We in the Department of Gynecology at the Cancer Institute Hospital actively performed total hysterectomies in such patients with no distant metastases and no extension of the parametrial induration to the pelvic wall, and obtained favorable results. In the present study, the clinical stage, histological type, degree of removal of involved tissue, and relationship between the prognosis and the maximum diameter of the tumor in the extirpated uterus were examined in 28 patients with advanced cervical cancer treated during the thirty-year period from 1957 to 1986. The following results were obtained: 1. The clinical stage and histological type of the cancer prior to radiation therapy did not significantly affect the prognosis after total hysterectomy. 2. The 3-year survival rate for the patients in whom all involved tissue could be removed was 81.0 percent. In contrast, all those in whom complete removal was impossible survived less than 3 years, despite additional therapy. 3. Prognosis was better in the patients who had tumors with a maximum diameter of less than 2 cm than in those who had tumors with a maximum diameter of 2 cm or more (p less than 0.05). 4. Patients in whom all involved tissue could be removed and in whom the maximum diameter of the tumor was less than 2 cm had a good prognoses, with 88.9 percent surviving at least 3 years after surgery.

Adenocarcinoma↗
PubMed1987

Changing incidence of hepatocellular carcinoma in Japan.

A trend in the incidence of hepatocellular carcinoma (HCC) in Japan was studied from the data of the Osaka Cancer Registry (population, 8,512,351 in 1981) for the period of 1963-1983, the Vital Statistics of Japan, Ministry of Health and Welfare, and the Japan Autopsy Registry which contained 594,132 individually filed cases in the 26-year period from 1958 to 1983. Both cancer registry data and autopsy records showed a more than 2-fold increase in HCC incidence, particularly in the last 10 years or so, among males and a less pronounced increase in females. The same trend was borne out by the cancer registries of Nagasaki City and Miyagi Prefecture and the Vital Statistics. When studied with the autopsy data, it was found that the numbers of autopsies for cirrhosis without HCC and autopsies for HCC (with and without cirrhosis) were about the same in 1958-1961 and that currently (1980-1983) the latter is about 2 times the former. As one of the possible causes of increase in HCC incidence other than prolonged survival of patients with cirrhosis, chronic non-A, non-B hepatitis is discussed.

Age Factors↗
PubMed1987

Time trends of the prevalences of hepatitis B e antigen positives among hepatitis B virus carriers in Japan.

In order to examine time trends of the prevalences of HBeAg positives among HBV carriers in Japan, we analysed data on HBeAg of HBsAg positive voluntary blood donors (23,560 males, and 8659 females) at the Osaka Red Cross Blood Centre between January 1977 and March 1984. Age-specific prevalences of HBeAg positives decreased year by year for both sexes, especially for those in their teens and twenties. The prevalences of HBeAg positives decreased with age, but at any given age it was lower for the later than for the earlier birth cohorts. Although reasons for the secular declines are unknown, the findings suggest that the prevalence of HBeAg positives among HBV carriers will continue to decrease in Japan. This, together with the immunization programme implemented this year, may lead to a future reduction in the risk of HBV related liver diseases in Japan.

Adolescent↗
PubMed1987

[Immunohistochemical study of new monoclonal antibodies--E29, 115D8 --to an epithelial membrane antigen (EMA) in ovarian tumors].

Mouse monoclonal antibodies E29 and 115D8 have been raised in the human milk fat globule membrane. The distribution of the antigen detected by these two monoclonal antibodies has been examined in formalin-fixed paraffin-embeded human ovarian tumors by an indirect immunoperoxidase technique. The highest positive rate of E29 and 115D8 was obtained in the malignant group suggesting that there is relationship between this positive rate and the histological malignancy. As for serous cystadenocarcinomas, a strong staining area of E29 was observed in the diffuse cytoplasm in poorly differentiated cases. These results suggest that the presence of E29 is a useful tumor marker for ovarian cancer.

Adenocarcinoma↗
PubMed1987

[Metastatic brain tumor after chemotherapy of ovarian cancer].

A case of brain metastasis in ovarian cancer is reported. Recently cis platin-containing combination chemotherapeutic regimens have improved the prognosis of patients with advanced ovarian carcinoma. Metastasis to the brain in ovarian cancer is very rare. However, the incidence of cerebral metastasis after chemotherapy for ovarian carcinoma seems to be increasing, and this may be related to prolonged survival due to chemotherapy. Thus, neurological examination after chemotherapy with cis platin is necessary to detect metastases to the brain.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1987

[Hachimijiogan having no estrogenic activity is effective for senile colpitis].

The effects of Hachimijiogan, a Chinese medicine, were studied in patients with senile colpitis. Eighty-eight postmenopausal patients, aged 42-76 years, were treated. Hachimijiogan was effective in 65 of 66 cases with abnormal discharge, 10 of 11 with pruritus vaginae and 60 of 62 with subepithelial hemorrhage. Overall more than ninety per cent of the patients responded well. The serum FSH, E1 and E2 levels were not statistically changed in this treatment. The vaginal Pap smear showed a significant decrease in parabasal type cells and an increase in intermediate type cells (p less than 0.01). Radioimmunoassay of E1, E2, E3, testosterone, FSH, LH and prolactin in Hachimijiogan were below the levels of sensitivity. These data suggest that Hachimijiogan is effective for senile colpitis and patients with senile colpitis associated with estrogen dependent tumors could be safely treated by Hachimijiogan.

Aged↗
PubMed1987

[The effect of bismuth subnitrate on cisplatin toxicity].

Bismuth subnitrate (BSN), a bismuth compound medically used for antidiarrheics, was orally administered to see whether it can reduce CDDP nephrotoxicity or not. Thirteen patients aged 19 approximately 60 with ovarian cancer entered this BSN-CDDP trial. A total of thirty three courses of BSN-CDDP treatment was undergone. BSN was administered orally at a dose of 50 mg/kg for five days before CDDP therapy. CDDP was infused for two hours. No vigorous hydration or diuresis was performed. Only 2,000 ml of saline with 20 mEq per liter of KCl was given for post-hydration. The median dose of CDDP was 100 mg/m2. The renal toxicity of BSN-CDDP treatment was minimum. 82% of the courses at the sixth day after the treatment had creatinine clearance levels which were more than 80% of those before the treatment. But twenty-four hour NAG and beta 2-microglobulin excretion were significantly increased. Bone marrow suppression and gastrointestinal disturbance were commonly observed. The results of our study indicate that BSN pretreatment reduces the renal toxicity of CDDP to some extent.

Acetylglucosaminidase↗
PubMed1987

[Clinical study of primary carcinoma of the fallopian tube: experience with 14 cases].

Between 1950 and 1986, 14 cases of primary carcinoma of the fallopian tube were treated and diagnosed at the Cancer Institute Hospital. These cases constituted 0.13% of the total number of gynecologic malignancies at the hospital during the period. The clinical/pathological findings and prognoses were described. Of the 14 cases, the average age was 56.0 years. The most frequent symptom was atypical genital bleeding, seen in 11 cases (79%). Massive watery discharge was seen in four cases (29%). In preoperative cytologic examination of vaginal smears, six cases (43%) were positive for cancer. All cases underwent operation as therapy. Postoperative irradiation, adjuvant chemotherapy, and/or second-or third- look operation was also used. Histopathologically, all materials were found to be adenocarcinoma. Four cases were well differentiated, seven were moderately differentiated, and three were poorly differentiated. Two patients with stage III and IV cancers died of the disease. Nine patients were still alive at the end of this study. The five-year survival rate was 57% (4/7). In stage I cancers, the five-year survival rate was 80% (4/5). The prognosis of stage I cancer patients was estimated as rather good.

Adenocarcinoma↗
PubMed1987

[An immunohistochemical study of the distribution of epithelial membrane antigen (EMA) in uterine carcinoma].

Epithelial membrane antigen (EMA) is a component of the human milk fat globule membrane. The production of EMA is increased in both squamous and non-squamous epithelium in a variety of diseases including many neoplasms. Using antihuman EMA monoclonal antibody, an immunoperoxidase stain for EMA was done in normal or neoplastic cervical epithelia and endometrium. Formalin-fixed paraffin-embedded tissues were obtained by either colposcopic biopsy or surgical excision of the uterus from 61 patients. Ethanol fixed imprint smears were obtained from surgically removed uteri from 84 patients. The difference between normal cervical squamous epithelium and dysplasia or carcinoma of the cervix in intensity or patterns of staining for EMA reflected the progression of the neoplastic change in the cervix. The different EMA localization in well differentiated adenocarcinoma and moderately or poorly differentiated adenocarcinoma of the cervix and the endometrium was correlated with histological differentiation.

Adenocarcinoma↗
PubMed1987

[Epidemiologic study of carcinoma in situ of the cervix].

During the period from 1950 to 1983, 1633 patients with cervical carcinoma in situ (CIS) were treated at the Cancer Institute Hospital, Tokyo. These cases were retrospectively investigated to determine the relation between the epidemiologic features and social phenomena. The number of patients with CIS tends to increase year by year. The incidence of CIS tends to be larger in the younger age group. Delay in the age of primiparity, a lower incidence of multiparas and a higher incidence of artificial abortion were seen in the CIS patients. Recurrence was seen in 0.4% of the CIS patients, and the recurrence site was most frequently the vaginal stump.

Abortion, Induced↗
PubMed1987

Second primary cancers following female breast cancer in Osaka, Japan--a population-based cohort study.

Using the data accumulated in the Osaka Cancer Registry, a cohort study was conducted on the occurrence of second primary cancers following the first breast cancer in females. Of the 9,503 breast cancer patients newly diagnosed in the period 1965-1982 who were followed up until the end of 1983 (average follow-up period, 5.7 years), 344 developed second cancers, whereas the expected number had been 211 (relative risk (RR) = 1.6; 95% confidence interval (CI) = 1.5-1.8). The increased risk was observed throughout the observation period, and was higher in patients of less than 45 years of age at diagnosis than in older women. Significant excess risks were found for second cancers of the opposite breast (RR = 4.2; 95% CI = 3.4-5.2), buccal cavity (RR = 3.6; 95% CI = 1.6-7.2), stomach (RR = 1.4; 95% CI = 1.2-1.8), colon (RR = 1.8; 95% CI = 1.1-2.1) and thyroid gland (RR = 3.2; 95% CI = 1.5-6.1). The effects of chemo- and radiotherapy administered for initial breast cancer on the increased risk of the above mentioned second cancers were also examined. These therapeutic measures were found not likely to be related to the excess risks for cancers of the buccal cavity, stomach and colon. For second cancer of the opposite breast, however, both chemotherapy and radiotherapy remained as possible risk factors. The effect of radiation was proposed as being a likely explanation for the excess risk of second thyroid cancer.

Age Factors↗
PubMed1986

Evaluation of a mass screening program for stomach cancer with a case-control study design.

In order to evaluate the effectiveness of a mass screening program for stomach cancer, a case-control study was conducted in Nose town in Osaka, Japan. The case series consisted of all deaths from stomach cancer during the period 1969-1981 (54 in males and 37 in females). For each case, 3 controls of the same sex and from the same precinct as the case, and born within 5 years of the case birth-year, were selected at random from Nose town residents alive at the date of death of the relevant case. We then investigated whether each case and corresponding controls had ever had screening tests before the date of diagnosis of the case. From the matched analysis of the distribution of screening in case-control combination, the odds ratio of screened vs. unscreened among those who died from stomach cancer compared to those who did not was calculated as 0.595 (90% confidence interval: 0.338-1.045) among males and 0.382 (0.185-0.785) among females. When the screening tests conducted within 12 months of diagnosis were ignored on the presumption that they were symptom-related, the odds ratio was calculated as 0.519 (0.297-0.905) among males and 0.486 (0.239-0.986) among females. These data strongly suggest that the mass screening program is effective in reducing stomach cancer mortality.

Adult↗
PubMed1986

Mortality among Koreans living in Osaka, Japan, 1973-1982.

The mortality pattern of Koreans living in Osaka, Japan was surveyed by comparing their age-specific and age-adjusted death rates with those among Japanese during 1973-1982. Cancer was the leading cause of death among Korean males, while cerebrovascular disease was most common among Korean females in Osaka. Mortality rates from tuberculosis, cancer, mental disorder, cerebrovascular disease, chronic obstructive pulmonary diseases (COPD), liver cirrhosis, accidents and suicide were significantly higher for Korean males than for Japanese males. COPD, liver cirrhosis and accidents were more frequent for Korean females than for Japanese females. In cancers, liver cancer was most common among Korean males, followed by stomach and lung cancers. Stomach cancer was most frequent among Korean females, followed by uterine and liver cancers. The ratio of cancer mortality rates for Koreans and Japanese was significantly higher than 1.0 for oesophagus, liver and lung among males, and for liver among females. Koreans had considerably higher levels of liver cancer and liver cirrhosis compared with Japanese. Mortality from stomach cancer was significantly lower in both sexes among Koreans in Osaka and the reduction of this disease among Koreans in Japan occurred more rapidly than among Japanese.

Adolescent↗