Search PubMed⌕ Search

Biomedical subjects

I Fujimoto

Publications and source records attributed to I Fujimoto.

At least 109 records · Page 6Linked to original sources
PubMed1989

[CDDP-ACR treatment in patients with recurrent ovarian cancer with prior chemotherapy containing CDDP--a preliminary study of a 14-day continuous infusion of CDDP with ACR].

Six patients with recurrent ovarian cancer who had prior chemotherapy were studied for the clinical efficacy of CDDP-ACR treatment. Five out of the 6 had received CDDP a total doses of 1,320, 780, 750, 475, and 340 mg. CDDP-ACR therapy consisted of continuous infusion of CDDP at a daily dose of 10 mg/m2 over 14 days (total CDDP doses; 140 mg/m2) and of intermittent infusion of ACR (aclarubicin) at a dose of 20 mg/body every other day (total ACR doses: 140 mg). There were one CR and five PR and a response rate up to 100% was noted. Toxicity was manifested in slight nausea or vomiting, but there was no nephrotoxicity. However bone marrow was severe. Thrombocytopenia less than 50,000/mcl in 4 pts (67%) and leukopenia less than 1,000 mcl in 3 pts (50%). The mean filterable platinum exposure measured by area under the concentration-time curve (AUC) was as high as 19.7 +/- 6/0 mg.hr/ml. In conclusion the bone marrow toxicity in this regimen was severe, but the therapeutic efficacy was promising. Further studies on the appropriate infusion time and the minimum effective dose of CDDP are needed.

Abdominal Neoplasms↗
PubMed1989

[Comparison of ultrasound and computed tomography (CT) for the diagnosis of paraaortic lymphnode metastasis in patients with gynecologic malignancies].

Fifty-one patients with gynecologic malignancies were tested for paraaortic lymphnode metastasis by ultrasound and computed tomography (CT). Eleven patients were found to have paraaortic lymphnode metastasis by ultrasound, and CT also showed the same metastatic image in the same patients. The site and size of the positive image found by both means were identical. The other forty patients diagnosed by ultrasound as free of metastasis were also proved to have no metastasis by CT. Ultrasound is as useful as CT in the evaluation of paraaortic nodes. However, ultrasound is more convenient and easier to use than CT.

Adenocarcinoma↗
PubMed1989

[The role of epidemiologic research of the natural history of cancer for evaluating cancer screening programs--a prospective study of colorectal polyps on the occurrence of colorectal cancer].

In order to elucidate the natural history of colorectal polyps and to examine the effectiveness of endoscopic polypectomy in reducing the incidence of colorectal cancer, we conducted a retrospective cohort study of all patients who had undergone endoscopic examination at the Center for Adult Diseases, Osaka in 1970-82. The study subjects consist of 653 non-polyp cases and 431 colorectal polyp cases including 222 cases treated by endoscopic polypectomy. These were followed up until the end of 1985 by the method of a record linkage with the Osaka Cancer Registry's file. The colorectal polyp group and the endoscopic polypectomy group experienced 4.4 and 2.9 times, respectively, as much incidence of colorectal cancer as the non-polyp group. The magnitude of the prevented fraction by the use of endoscopic polypectomy was estimated at 31.3%. A large-scale and long-term study is necessary to elucidate the original study purpose.

Adult↗
PubMed1989

[Cervical cancer after subtotal hysterectomy (so called "stump cancer")--clinical studies on 226 cases].

The Department of Gynecology of the Cancer Institute Hospital diagnosed and treated 226 cases of stump cancer between 1950 and 1983. We obtained the following results. 1) The age of the subjects ranged from 32 to 78 years. The highest frequency age group was 50 to 59 (44.7%) with 101 cases, giving an average age of 53.8 years. 2) Subtotal hysterectomy was performed at ages 23 to 64, the average age being 39.5. 105 patients (46.5%) underwent subtotal hysterectomy between the ages of 40 and 49. 3) The major reasons for subtotal hysterectomy were myoma in 181 cases (80.1%), benign ovary tumor in 12 cases (5.3%), ectopic pregnancy in 10 cases (4.4%), cystic mole in 6 cases (2.7%) and cesarean section in 5 cases (2.2%). 4) Major subjective symptoms of stump cancer were metrorrhagia in 164 cases (72.6%) and fluor in 30 cases (13.3%). 24 cases (10.6%) were asymptomatic. 5) The hystological types were squamous cell carcinoma in 208 cases (92.0%), adenocarcinoma in 17 cases (7.5%), and adenosquamous cell carcinoma in 1 case (0.4%). These ratios were similar to those of cervical cancer cases treated over the same period. 6) The stages of cancer advancement were stage 0 in 24 cases (10.6%), stage I in 51 cases (22.6%), stage II in 96 cases (42.5%), stage III in 50 cases (22.1%), and stage IV in 5 cases (2.2%). The percentage of stage 0 cases was lower than that for general cervical cancer of the uterus.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenocarcinoma↗
PubMed1989

[Clinicopathological study on clear cell carcinoma of the ovary].

The clinical and pathological findings in 23 cases of clear cell carcinoma of the ovary treated at Cancer Institute Hospital from January 1951 to September 1987 are discussed. Clear cell carcinoma accounted for 7.1% of all malignant tumors of the ovary. In the last 21 months of the study, the incidence of clear cell carcinoma increased to 23.7 at the institute. This tumor was frequently associated with endometriosis, and the ratio of nulliparous women was as high as 47.8%. Operative findings revealed adhesion of the tumor to surrounding tissues in more than half of the cases. Moreover, rupture of the tumor capsule during operation occurred in 42.1% of the cases. Incidences of clear cell carcinoma by clinical stage were 82.6% for stage I, 8.7% for stage II, 8.7% for stage III, and 0% for stage IV. The incidences of serous carcinoma were 20.8%, 24.2%, 45.8%, and 9.2%, respectively. Histologically, clear cell carcinoma could be divided into solid and tubular types, with the solid type being slightly more frequent. The three-year survival rate for stage I cases was 95.2% for serous carcinoma and 54.5% for clear cell carcinoma, showing a poor prognosis for clear cell carcinoma. When classified by the histologic type of clear cell carcinoma, the three-year survival rate was 50.0% for solid type and 60.0% for tubular type, with no significant difference. For clear cell carcinoma, the prognosis was poor despite even though most cases were stage I.

Adenocarcinoma↗
PubMed1989

Peritoneal fluid cytology and prognosis in patients with endometrial carcinoma.

Cytologic examination was performed on peritoneal fluid collected from a total of 235 consecutive patients with endometrial carcinoma who underwent laparotomy as the initial treatment at the Cancer Institute Hospital from 1971-1985. The rate of cases positive for cancer cells in the peritoneal cytologic examination was 18.7% for all stages (44 of 235 cases). In stage I endometrial carcinoma, the 5-year and 10-year cumulative survival rates with positive peritoneal cytologic findings were 91.6 and 90.0%, respectively; those in cases with negative cytologic findings were 90.2 and 90.2%, respectively, with no significant difference. The recurrence rate in the same stage was 12.0% for cytologically positive cases versus 9.5% for negative cases. In stages II and III, no significant difference was noted in the survival rate between nine cases with positive peritoneal cytologic findings without macroscopic peritoneal metastasis and 47 comparable cases with negative cytologic findings. Therefore, in endometrial carcinoma, the presence of malignant cells in peritoneal fluid is not a useful prognostic factor.

Female↗
PubMed1989

[A case-control study of stomach cancer in young females, with special reference to the effects of pregnancy and delivery].

To investigate the effects of pregnancy and delivery on stomach carcinogenesis, we have conducted a case-control study. The cases consisted of females aged 34 or below who had been histologically diagnosed as having a stomach cancer, covering a period from 1967 to 1986 at the Center for Adult Diseases, Osaka. Our birth-year-matched controls were selected from female examinees who had undergone a gastroendoscopy in 1986. In this manner, a total of 79 cases and 158 controls were obtained. For women in the age group from 30 to 34, a history of their pregnancies and deliveries seemed to have protective effects on stomach carcinogenesis (RR = 0.36, P less than 0.05), whereas for those in the age group under 30, it appeared to be a risk factor for stage IV stomach cancer (RR = 4.42, P less than 0.05).

Adult↗
PubMed1988

Relationship between cigarette smoking and histologic type of lung cancer, with special reference to sex difference.

In order to clarify sex differences associated with the relationship between smoking and each histologic type of lung cancer, the smoking histories of 2,083 lung cancer patients (1,660 men and 423 women) diagnosed at the Center for Adult Diseases, Osaka, from 1965 to 1983 were analyzed. The rates expected of smokers among these cases were calculated from the sex and age specific rates of smokers in the general population, reported annually by the Japan Tobacco and Salt Public Corporation. The odds ratios for smoking were estimated to be 5.2, 3.1, 6.9, and 4.1 in men for squamous cell carcinoma, adenocarcinoma, small cell carcinoma and large cell carcinoma, and 7.2, 1.8, 14.4 and 3.8 in women respectively. Significant differences in the odds ratios for each histologic type between men and women were observed only for adenocarcinoma. In squamous cell carcinomas, the odds ratios were estimated by dividing them into two groups according to location. No difference was found between men and women in this respect.

Adenocarcinoma↗
PubMed1988

A comparative epidemiologic study on geographic distributions of cancers of the lung and the large intestine in Japan.

To examine what kinds of factors could have caused the geographic variation observed in lung cancer morbidity in Japan, a correlation study was performed comparing various regional traits. The same study was also conducted on large intestinal cancer, aiming to distinguish the possible urban factors associated with both cancers. Lung cancer was highly correlated with industrialization-related factors such as localization of manufacturing industries, automobile traffic and air pollution, whereas colon cancer was correlated with the population density of workers in the tertiary industries such as services, trade and government. A multiple regression analysis could not detect any single factor with an exceptionally strong influence on either cancer. The present findings suggest that the hazardous environmental condition of urban areas has, to some extent, contributed to the recent increase of lung cancer cases in this country.

Age Factors↗
PubMed1988

A case-control study of the effectiveness of cervical cancer screening in Osaka, Japan.

In the small town of Nose in Osaka, Japan, a population-based screening program for cervical cancer by Papanicolaou smear has been conducted since 1965. In order to evaluate the effectiveness of screening in terms of the reduction of the mortality and the incidence of invasive cervical cancer, two types of case-control studies were carried out. In the first study, the case series consisted of all women who died of cervical cancer under 80 years of age at the time of diagnosis in 1965-1987 (N = 15). For each case, 10 controls were chosen from living residents, matched by year of birth. It showed that the odds ratio (OR) of dying of cervical cancer for screened versus non-screened women was 0.22 (95% CI = 0.03-1.95). In the second study, the case series consisted of all women who were diagnosed as having invasive cancer under 80 years of age at the time of diagnosis in the same period (N = 28). For each case, 10 controls were chosen from living residents without invasive cancer, matched by year of birth and according to whether or not they were screened at the year of the diagnosis of the matched case. It showed that the OR of getting invasive cancer for screened versus non-screened women was 0.41 (95%CI = 0.13-1.29). From these results, it was estimated that 78% of cervical cancer mortality and 59% of invasive cervical cancer incidence among non-screened women could be prevented by cervical cancer screening.

Adult↗
PubMed1988

Comparison of lung cancer incidence rates by histological type in high and low incidence countries, with reference to the limited role of smoking.

To find a clue to lung cancer etiology in Japan, differences in the pattern of lung cancer histology and related time trends between Osaka, Japan, and the North West Region of England were investigated. Material comprised all incident lung cancer cases registered in both regional registries (14,521 in the Osaka Cancer Registry and 29,859 in the North West Regional Cancer Registry). (1) The age-standardized incidence rate of lung cancer was higher in the North West Region than in Osaka (80.4 among males and 20.9 among females per 100,000 population in 1979-82 versus 32.1 and 9.2 respectively). (2) A higher proportion of adenocarcinoma was observed in Osaka (36.3% in males and 62.0% in females) than in the North West Region (12.3% and 18.9% respectively). (3) Using the relative frequencies of each histological type according to sex and age-group, age-standardized incidence rates were calculated for the main lung cancer histological types. It was shown that the incidence rates of adenocarcinoma were similar in the two areas (10.6 in males and 5.3 in females in Osaka versus 10.0 and 3.5 in the North West Region, respectively) while those of squamous cell and small cell carcinomas were much higher in the North West Region than in Osaka. (4) Time trends of incidence rates showed an increase only for adeno- and small cell carcinomas in Osaka. Slight increases were observed for adenocarcinoma in both sexes and for squamous cell carcinoma in females in the North West Region. (5) Considering cigarette consumption and the relative risks of smoking in the two areas, the possible existence of other risk factors for adenocarcinoma in both sexes in Japan, besides active smoking, was suggested.

Adenocarcinoma↗
PubMed1988

[Effect of medical vagotomy on the CDDP induced nausea and vomiting evaluated by the chemotherapy-vomiting time (CV time)].

Twenty-eight patients with gynecologic malignancies receiving combination chemotherapy containing cisplatin (80 mg/m2) entered into a randomized controlled trial to evaluate the effect of medical vagotomy for acute cisplatin-induced emesis. Medical vagotomy consisted of 0.5 mg of atropine and 50 mg of hexamethonium bromide, and was injected three times at two hour intervals intramuscularly. A good antiemetic effect (no emesis during the 24 hours after cisplatin administration) was obtained in 40% (6/15) of patients with medical vagotomy but in 0% (0/13) in controlled cases. The time free of vomiting after cisplatin injection (CV time) was statistically prolonged in patients with medical vagotomy (805 +/- 563 min.) when compared with controlled cases (148 +/- 70 min.) (p less than 0.01). Toxicities with medical vagotomy were slight; mild hypotension and dimness of vision only. Individual differences in responding to medical vagotomy were investigated by the acetaminophen method, which showed that high and low responded cases were among these tested patients who had undergone medical vagotomy. In conclusion, medical vagotomy has an excellent antiemetic effect on acute cisplatin-induced emesis without notable side effects. If combined with other antiemetics, a much better antiemetic effect can be expected.

Acetaminophen↗
PubMed1988

[Predictions of the incidence of cancer in Japan in the year 2000].

The incidence of cancer in Japan in the year 2000 was predicted according to sex, age-group, and primary site, using the annual incidence data in the Osaka Cancer Registry for 1966-83 and the annual standardized mortality ratio of Osaka residents to all residents of Japan in 1966-83. (1) The incidence of cancer in Japan in the year 2000 was predicted to reach 479,500 cases (365.5 per 100,000 population), or a 1.66-fold increase over that of 1985. Forty-nine percent of these cases would be aged 70 years or older. (2) As for the 5 leading cancer sites in the year 2000, out of this total of 479,500 cancer cases, 80,300 were estimated to occur in the lung, 77,200 in the stomach, 45,200 in the colon, 35,500 in the liver and 28,000 in the breast.

Female↗