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H Wuthe

Publications and source records attributed to H Wuthe.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Discriminating power of multivariate parameters of respiration in epidemiological studies (author's transl)].

Applying a broad scale of lung function tests in epidemiological surveys (929 metal workers of a big industrial shop, 211 of them with signs of chronic obstructive lung disease, COLD, and 1,266 pupils of 2 towns with different dust exposition) we found similar multivariate discriminant functions in all age groups between 7 and 79 years of age to differentiate between COLD-population and normal population. Residual volume in % of total capacity (RV/TC) seems to be the most relevant central parameter in all age groups, which should be combined with one of the inhomogeneity parameters of single breath or multi breath distribution tests ( delta F/ delta V or breath of inhomogeneity IHB) in juveniles between 7 to 16 years of age and with closing volume (CV/VC) in adults between 20 to 79 years of age. Conventional ventilation parameters and the arterial oxygen tension don't contribute additional information to multivariate analysis, which isn't already summarized by the parameters RV/TC.

Adolescent↗
PubMed1981

[Airway-resistance in pregnancy measured by oscillation-technique (author's transl)].

Measurements of resistance were performed in 430 healthy pregnant women, 30 non-pregnant women and 33 puerperae by employing the oscillation-technique. The patients were studied in sitting and standing positions. It was found, that 2 maxima of resistance exist in pregnancy: the first in the 6th, the second in the 9th month. In the sitting position the resistance was higher than in the standing one.

Airway Resistance↗
PubMed1981

[A contribution to bullous emphysema].

Bullous pulmonary emphysema is a disease predominantly occurring uni- or bilaterally in men. While smaller localized bullae in the apex of the upper lobes may be the cause of spontaneous pneumothorax in younger asthenic patients, it may be the cause of fatal situations in older patients by rupture of giant bullae. False diagnosis between partial spontaneous pneumothorax and bullous emphysema are common, even now. The therapy of choice in all patients with bullous emphysema and still sufficient pulmonary function is surgical treatment with taking away the bullae. Only in patients older than 70 years with cardiorespiratory failure a longer lasting drainage therapy seems to be indicated. The results of all cases with bullous emphysema (47) treated in the thoracicosurgical department of the Research Institute for Pulmonary Diseases and Tuberculosis within 27 years are reported.

Adult↗
PubMed1980

Site and type of impaired lung function in extrinsic allergic alveolitis.

We investigated 109 persons exposed and sensitized against organic antigens. 46 of them (group I) are affected with the typical clinical and roentgenological signs of allergic alveolitis. The other 59 subjects (group II) were sensitized only. Included in all examinations were immunological diagnosis by means of counterimmunoelectrophoresis, systematic interviewing for case histories, and registration of respiratory symptoms. Pulmonary function was recorded by means of the following techniques: analysis of ventilation (flow-volume indices), respiratory mechanics of the larger airways and lung (body plethysmography, esophageal balloon technique), respiratory mechanics of the small airways (closing volume, amplitude of cardiogenic oscillations), distributional analysis, diffusion analysis, blood gas analysis, and right heart catheterization. Extrinsic allergic alveolitis caused changes in lung mechanics, in airways as well as in lung tissue. The most impressive findings in allergic alveolitis are mechanical inequalities of ventilation. These inequalities may be caused by changed mechanics of overall airways indicated by obstruction parameters and by changed structure of lung tissue reflected in decreased compliance, transfer factors and increased pulmonary arterial pressure. Not only a restrictive but also an obstructive disturbance of ventilation is found. Impairments are less in sensitized persons. We find slight mechanical and ventilatory inhomogeneities. An overall airway obstruction is obvious but not to such a large extent as in allergic alveolitis. On the contrary, here the lung tissue is not affected. Compliance and diffusion are within the normal range. There is no typical functional pattern specific for the diagnosis of allergic alveolitis.

Adult↗
PubMed1979

[Reference values of the residual volume for the rvo2-method (author's transl)].

Residual volume and the relative RV/TLC (total lung capacity) were measured in 632 men and 191 women aged 15 to 70 years. The residual volume showed a significant correlation to age and body height, but not to the relative body weight (Broca-Index). The values of RV/TLC showed a correlation to age and Broca-Index, but not to the body height. The regression formular to calculate the normal range are given; they comply with the data of other authors.

Adolescent↗
PubMed1978

[Frequency of lung function disturbances of industrial poultry farmers (author's transl)].

The frequency of antibodies against organic dusts of fowls were examined on 339 poultry farmers. 22% of workers had 1 antibody and 3% had 2 antibodies in the serum. The ventilation, the arterial oxygen tension, the residual volume, the Slope Index, the closing volume of each person were measured in the mobile laboratory. Signs of central obstruction and equal ventilation were found in sensitized persons (2 antibodies) about four times more than non-sensitized persons. Suitable lung function screening parameters were the FEV1/FVC and the Slope Index.

Allergens↗
PubMed1978

[Reference values of respiratory parameters in adults 4th paper: reference values for screening parameters of lung mechanics (author's transl)].

Reference values for screening parameters, evaluating the shape of flow-volume-curves on forced expiration, were calculated from measurements in 1127 healthy subjects aged between 13 and 72 years. The following parameters were determined by means of the electronic spirometer pneumo-test: 1. the peak flow value Vmax, 2. the whole time constant tauges of the flow volume diagram and its components tau1 and tau2 from the upper and the lower part of the flow volume curve, 3. the most frequent time constant taumax in the distribution function of time constants. In relation to age Vmax-values show a maximum at 35 years and a significant decrease in younger and older subjects. Values in women are significant smaller than in men throughout the range of age. The time constants tauges and tau1 decrease significantly with increase in age. Differences between females and males are not statistically significant for these parameters. The time constants tau2 and taumax are age-independent. Their mean values are identical in all age decades and in women significantly smaller than in man.

Adolescent↗
PubMed1977

[Smoking in the childhood--results of the school study Berlin-Karow 1976 (author's transl)].

The smoking habits and the lung function of 369 boys and 340 girls aged 6-16 were examined in a school. The boys are beginning to smoke at the age of 9, the girls at the age of 13. 62 per cent of the children aged 16 are smoking (20 per cent of the girls and 30 per cent of the boys are smoking regularely more than 1 cigarette/day). 58 per cent of the children have a smoker in their family. Only 10 per cent of the parents have knowledge about the smoking of their child aged 12, and 59 per cent of the parents of their child aged 16. The lung function tests (ventilation, distribution, bodyplethysmography, single-breath-test, blood gases) of the healthy teen-agers dont show differences between smokers and non-smokers.

Adolescent↗
PubMed1976

[Results of comprehensive respiratory function tests in CNSLD (author's transl)].

34 persons with CNSLD, but fit for work, were examined with the aim to record the degree of disturbance of pulmonary function and the underlying pathophysiological mechanism. The results were compared with 30 healthy subjects. The following function tests were carried out under resting conditions and bicycle ergometer exercises: Analysis of ventilation (FVC% pred., FEV1% FVC, RV% pred., RV% TLC), analysis of lung mechanic (Raw, CL) measurement of diffusion (DL, DM, Vc, DL% pred.) and analysis of lung inhomogeneity (RE/REO, V2/V1, CL6/CL100, deltaFN2/deltaV500, deltaFCO2/deltaV500,IHB). The results were analyzed and evaluated by using the digital computer C 8205. Persons suffering from CNSLD were showing among typical clinical symptoms the following disturbances of lung function: The obstructive ventilation disturbance stands in the foreground in connection with signs of inhomogeneity of lung mechanics and ventilation. While the resistance already shows the airway obstruction objectively under resting conditions, the decreased compliance is measurable at first under exercise. The disturbance of diffusion, which is pointed out, is mainly a latent decreased diffusing capacity of alveolo-capillary membrane. These disturbance of diffusion gets more importance because the inhomogeneity of lung hides the real disturbance of diffusion. The pathophysiological consequence of disturbed partial functions of respiration is the latent hypoxaemia without hypercapnia, therefore the signs of respiratory partial insufficiency.

Adult↗
PubMed1976

[Comparison of lung-mechanical and physico-chemical Parameters in view of the pulmonary surfactant system (author's transl)].

Evaluation of static pressure-volume-diagram of lungs and of surface-tension-area-diagram of lung-elutions measured on the Lamgmuir-balance is tested. Well known parameters are used to characterize alveolar surfactant activity in guinea pigs after perbronchial application of extracorporal surfactant Tacholiquin and detergent "Fit" 1% and after application of vagomimetics Acetylcholine 1% and Histamine 0.1%. Mean values of physico-chemical parameters show the most significant increase of the area of hysteresis (Benzer) during Tacholiquin and Acetylcholin application; the minimal surface-tension: gamma min, and the compressibility-index: gamma min/delta gamma (Kötter, Rüffer) decreased, the difference between maximal and minimal surface-tension: delta gamma and the stability-index: 2 delta gamma/(gamma max + gamma min) (Clements) increased. Tacholiquin and Acetylcholin both improve pulmonary surface-activity. The Tacholiquin-effect is documented in lung mechanics only by elevation of the inspiratory volume-rations: V10I/V20I (Clements) and V10I/Vmax (Kittelmann) referred to static pressure 10, 20 cm H2O and maximal pressure but not by elevation of the expiratory stability index V10E/Vmax (Gruenwald). The area of hysteresis is decreased indicating a preponderant inspiratory effect. The Acteylcholin-effect is covered by the well-known bronchial obstructive effect. Both inspiratory constants are decreased, and the area of hysteresis is increased. We did not find any significance of the expiratory stability index. Both inspiratory constants and the area of hysteresis are conditional surfactant parameters in view of bronchial obstruction.

Acetylcholine↗
PubMed1976

[Functional analysis in experimental respiratory distress syndrome (author's transl)].

After injection of an anti-lung -serum a respiratory distress syndrome could be produced in spontaneously-breathing guinea pigs. Reduced compliance, increased resistance and work of breathing was found. Morphological investigations showed intraalveolar and interstitial bleedings and a lung edema. Biochemically a decreased total phospholipid content could be found. Surface tension characteristics, examined with the Langmuir balance, were deteriorated. A complete restitution of surface tension parameters and total phospholipid content was obtained by administration of bromhexin metabolit Na 872.

Animals↗