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Biomedical subjects

H Wilken

Publications and source records attributed to H Wilken.

At least 55 records · Page 3Linked to original sources

[Pre-, peri- and postnatal factors in 419 handicapped children of a specific region].

A retrospective analysis was done in 419 children with handicaps, born 1966-1980 in a territory. In comparison with 419 children with normal development the following factors were found more often in the group with handicaps: Mother older than 30 years, brothers and sisters with handicaps, low birth weight, low placental weight, obstetric operations, vaginal labour in breech presentation, low Apgar score, neonatal reanimation, transfer in a children hospital, pathological reflexes in newborn, retardation of early development, bad social environment.

Abnormalities, Multiple↗

[Prevention of sterility].

An overview is given about possibly preventable causes of infertility. The best chances for prevention are in tubal sterility and ectopic pregnancy. Methods of "primary prevention" are reduction of STD by health education and epidemiologic actions, by reduction and improvement of intrauterine operations in young women. The most important methods in "secondary prevention" are early and optimal treatment of PID and organ preservation in ectopic pregnancy. The difficulties in prophylaxis of endocrine infertility are discussed. For prevention of male infertility some procedures are necessary: Prevention resp. optimal treatment of genital infections, early treatment of development disorders and varicocele and elimination of chemical and physical noxes on male fertility.

Female↗

[Damage pattern in 419 handicapped children in one region].

Report about 419 children with handicaps, born 1966-1980 in one territory. 9.8 per cent of these 419 children have a severe damage, not able for education. 11.9 per cent have a moderate damage and 78.3 per cent a mild one. The mental retardation is combined with damage of senses, cerebral palsy and seizures. Frequency of children with handicaps seems to decrease in the last years.

Adolescent↗

[In vitro fertilization program in therapy of the sterile marriage. International status and personal experiences].

A review is given about in vitro fertilization (IVF/ET) and embryo transfer in the treatment of sterile couples. Programmes of in vitro fertilization of successful international groups are analysed and discussed, especially the improvements of the method. These international reports were the basis of the programme of in vitro fertilization at women's hospital of the Wilhelm Pieck University at Rostock. The organization of the programme depends on local conditions. Treatment is performed in some so-called IVF-series. The results of the first and second series with 52 patients are reported. The only pregnancy during the second series was an ectopic pregnancy.

Adult↗

[Problems of ethics in research and practice in reproduction medicine].

The methods in management of infertility with manipulating of gametes require new ethical positions. In GDR artificial donor insemination, in vitro fertilisation and embryo transfer are ethically accepted because they are important possibilities for accomplishment of life in a childless partnership. The problems with egg and embryo donation, surrogate mother and other new methods are discussed.

Embryo Transfer↗

[The toxic shock syndrome].

The toxic shock syndrome in a serious disease. It occurs predominantly in menstruating women using tampons. About 40 deaths are associated with toxic shock syndrome. In the majority of cases Staphylococcus aureus was isolated from cervix and vagina. Most of the cases were observed in United States.

Female↗

[Current status of the development of interceptive agents].

An account is given of present applications of interceptively acting substances. Pharmaceuticals used so far for postcoital conception (oestrogens, gestagens, and combinations of these) are suitable for single application, but their regular use is limited by side-effects. Various approaches are being taken to the development of effective interceptives for high-continuity application but with low side-effects. Antigestagens, LHRH-analogues, and immunological contraceptives seem to be among the most promising classes of substances for the above purpose. Yet, none of these substances has been developed as yet to the level of clinical applicability.

Animals↗

[Is the treatment of breast diseases the responsibility of gynecologists?].

The answer is affirmative to the question whether mammary diseases should be treated by the gynaecologist. An attempt is made to substantiate this view by making reference to essential aspects relating to diagnosis and therapy of mammary diseases. Examination of the female breast is part of gynaecological routine diagnosis. Women with mammary complaints usually apply first to their gynaecologist. The female breast, after all is one of the reproductive organs exposed to endocrine effects, just as the genital organs are. Methods of endocrinological therapy have gained growing importance for both benign mammary diseases and mammary carcinoma.

Adult↗

[Problems of intra-uterine infections (author's transl)].

Mental and/or physical defects are recordable from seven or eight per cent of all children. While many causes may be responsible, some of them are associated with intra-uterine infections. Aetiological relationship between intra-uterine infection and embryonic or foetal damage has been studied in greater detail and secured so far only for some pathogens. These are quite often grouped under the acronym of TORCH (T = toxoplasmosis, O = others, including syphilis, listeriosis, and varicella, R = rubella, C = cytomegalovirus, H = herpes simplex). The following complexes are also related to the problem of intra-uterine infections: prevention of the infection in pregnant women and thus embryos (primary prevention), diagnosis of certain infections during pregnancy and resulting steps (secondary prevention) as well as early diagnosis and therapy of newborns for congenital infections. Every pregnant woman should be included in a screening scheme for detection of rubella, toxoplasmosis, and, possibly, cytomegalovirus infection, somewhat comparable to what has been general practice for syphilis for a long time. Better methods actually are available for such schemes, against the background of more or less recently devised approaches to diagnosis, such as the ELISA technique by which to identify specific IgM antibodies.

Congenital Abnormalities↗

[Psychic attitude of women to irreversible contraception (author's transl)].

Thirty-four of 100 women who had undergone officially sanctioned irreversible contraception at the Gynaecological Department of Wismar Regional Hospital were selected at random for follow-up investigation, two-and-a-half to one year after the intervention. The following psychological tests were taken: a standardised interview based on abridged psychopathological method, Freiburg personality inventory, record of complaints according to Kasielke, and the multiple-choice vocabulary test according to Lienert. Psychiatric examination was added on the basis of a structured psychopathological record system according to Grünes and Kühne. The following results were obtained from the study: All probands exhibited positive attitudes to the method of irreversible contraception. They said they would choose the same option, if they had to were asked again. They recommended the same decision to other women. Inner conflicts because of the irreversible nature of the intervention, problems of selfvalue, and impairment of partnership relations were not reported. Nor did any of the women wish refertilisation. The gynaecological intervention did in no single case turn out as source for neurotic developments or other psychiatrically relevant symptoms. However, the possibility of neurosis must be reckoned with, as it must with any other medical intervention. This risk may be effectively encountered by due consideration of the patient's personality, clarified indication, adequate information, and therapeutic support for the patient's effort to get to grips with the psychic problem. Hence, irreversible contraception can be an alternative, also for its psychic consequences, for women above 35 to whom safe reversible contraceptives cannot be applied for whatever reasons, although they have completed their own family planning.

Adult↗

[Results obtained from lumbar catheterisation for epidural analgesia for painless labour (author's transl)].

Experience obtained from 115 childbirths with catheterisation for epidural analgesia is reported in this paper. Reduction of labour pain was optimum with all patients.--The rate of CTG alterations and acidosis of foetal blood was not beyond that recordable from normal deliveries. The rate of vaginal surgery was increased to 14.8 per cent due to one patient in whom expulsion was delayed and the expulsion period thus prolonged.

Anesthesia, Epidural↗