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Biomedical subjects

H Voigt

Publications and source records attributed to H Voigt.

At least 91 records · Page 5Linked to original sources
PubMed1981

[Ambulatory hemodilution therapy of peripheral arterial circulation disorders].

Ambulatory isovolaemic haemodilution in 10 patients with disturbances of the arterial blood supply of the stages II-IV after Fontaine resulted in an increase of the distance of claudication intermittens as well as in an occlusion-plethysmographically measurable increase of the reactive blood supply of the legs. The indications, contraindications and precautionary measures of the haemodilution therapy of advanced disturbances of the blood supply are discussed.

Adult↗
PubMed1981

[Thrombosis therapy and the prophylaxis of thrombosis recurrences in obstetrics].

IN general the therapy of thrombosis during pregnancy is carried out with heparin, in which case the initial hospital treatment may be continued later on with double subcutaneous applications of heparin in the out-patient department. Apart from coagulation-physiological parameters plethysmography and/or ultrasound Doppler method serve for the control of the course. Within the prophylaxis of recidivations in earlier thromboembolism during pregnancy regular clinical and apparative controls are performed, in which cases in the last third of the pregnancy the possibilities of the consideration work are used. Immediately pre-, intra- and postpartally heparin is injected with low dose up to the optimum phenprokoumon regulation (beginning with the 2nd day post partum). Thromboses in the anamnesis are no essential risk, when an optimum prophylaxis of thrombosis is guaranteed during pregnancy and puerperium

Adult↗
PubMed1981

[Veno-occlusive syndrome with acute liver dystrophy following decarbazine therapy of malignant melanoma (author's transl)].

Case report about death due to veno-occlusive liver disease following Dacarbazine treatment: 9 years after surgical treatment of malignant melanoma of the trunk a 68-years old patient developed lymph node metastases in the right axilla, which were removed immediately by surgical excision. One month before the patient had undergone surgical treatment of empyema of the gallbladder: Cholecystectomy and appendectomy were performed, postoperative recovery was uncomplicated. On account of the second lymph node metastasis within nine months adjuvant treatment with Dacarbazine was agreed and started one month later. After having performed the first course of treatment without any hints to intolerance the patient suddenly exhibited severe shock symptoms on the fourth day of the second course. Clinically residual myocardial infarct or pulmonary embolism were assumed, but could not be verified. The patient delivered increasing hepatomegaly. A massive increase in transaminase values was noted. Hemostasiologic changes with decreased Quick value occurred. The patient died of cerebral hemorrhage five days after beginning the second Dacarbazine cycle. Autopsy findings were severe liver cell necroses as well as liver vein thromboses, no metastases of melanoma could be found. Hepatotoxicity of Dacarbazine and the mechanism of liver vein thrombosis are discussed with special regards to possible hemostasiologic changes and sensibilisation due to Dacarbazine and/or previous liver cell damage.

Aged↗
PubMed1981

[Scintigraphy of liver after combined chemo-/immunotherapy with malignant melanoma (author's transl)].

Thirty patients with malignant melanoma received combined chemo-/immunotherapy with Dacarbazine and BCG after operation. Before therapy and 6-10 weeks after the liver was examined by clinical, laboratory and scintigraphic means. We wanted to find out the side effects of the therapy on liver and the use of the gated scintigraphy to diagnose liver parenchymal changes. Each of the patients had normal laboratory results as well as a normal scintigraphy before therapy. After chemotherapy 19 patients had a pathological liver scintigram. Also specific liver enzymes were elevated. While 12 patients showed a diffuse, inhomogeneous liver pattern with scintigraphy, 5 patients had an additional diffuse liver increase on top. Four patients also showed signs of intrahepatic cholestasis. In 11 patients the result was unsignificant. Related to the liver toxicity of Dacarbazine, liver scintigraphy is able to detect a liver reaction at a point where laboratory and clinical signs don't give a significant information.

Adult↗
PubMed1981

[Complications of experimental lung transplantations].

Experimental lung transplantations are burdened with a very high rate of complications even is there is a strict consideration of sterile precautions. These complications occur predominantly directly in connection with organ rejection. Extrathoracic complications are rare and predominantly attributed to arterial embolism. All untreated receivers of lung had thoracic complications in autopsy. Only 5% of immune suppressively treated receivers were free of complications. Most frequent complications are pleuropulmonary infections. Weighty complications are haemorrhagic infarcts of the transplant and insufficiency of the bronchus. Only without complications can survived about years the chronic rejection.

Animals↗
PubMed1981

[Results of studies on dogs after unilateral allogeneic lung transplantation without immunosuppression].

The observations and the results after allogenic lung transplantation in 24 receivers were reported. The animals were not treated immuno-suppressively. They survived 6.2 days on an average and died in consequence of the rejection. The transplant is progressively threatened of bacterial infections after the beginning of the rejection even in case of an operation under sterile conditions. The investigations confirmed a narrow correlation between the leucocyte count and the course of the rejection. However, the condition of the transplant can be estimated approximately certainly by means of complex clinical methods of examination.

Animals↗
PubMed1981

[Influence and importance of dacarbazine and BCG in sonography of the liver (author's transl)].

Basing on results obtained in a group of 30 patients with malignant melanoma, the authors investigated the influence of therapy with cytostatics and of immunotherapy with dacarbazine or BCG, respectively, on the sonographic findings in examination of the liver. In 6 patients, we recorded a larger echo reflex pattern subsequent to therapy, similar to the observations made in diffuse changes in the liver and in the formation of multiple metastases in the liver. This complicated the differential sonographic assessment in respect of excluding multiple liver metastases. Diffuse growth occurred in three patients; we did not observe any extended branches of the protal vein, nor did we see any changes in the biliary tract pattern.

BCG Vaccine↗
PubMed1981

[A contribution to bullous emphysema].

Bullous pulmonary emphysema is a disease predominantly occurring uni- or bilaterally in men. While smaller localized bullae in the apex of the upper lobes may be the cause of spontaneous pneumothorax in younger asthenic patients, it may be the cause of fatal situations in older patients by rupture of giant bullae. False diagnosis between partial spontaneous pneumothorax and bullous emphysema are common, even now. The therapy of choice in all patients with bullous emphysema and still sufficient pulmonary function is surgical treatment with taking away the bullae. Only in patients older than 70 years with cardiorespiratory failure a longer lasting drainage therapy seems to be indicated. The results of all cases with bullous emphysema (47) treated in the thoracicosurgical department of the Research Institute for Pulmonary Diseases and Tuberculosis within 27 years are reported.

Adult↗
PubMed1980

[Trials with therapeutic plasmapheresis in pemphigus vulgaris].

A seventeen year old female with pemphigus vulgaris was treated by exchange plasmapheresis. Plasmapheresis was performed five times over three weeks. Each procedure significantly reduced the serum level of intercellular antibodies. Without immunosuppressive therapy and with only moderate doses of corticosteroids the clinical symptoms had improved after the three weeks period. Plasmapheresis represents an alternative therapeutical possibility in the treatment of pemphigus vulgaris in order to achieve a rapid reduction in circulating levels of the intercellular antibodies.

Antibodies↗
PubMed1980

[Dependence of hippuric acid excretion in urine on the toluol concentration and the respiratory volume per minute].

In inhalative toluol loads lasting one hour a dependence of the secretion of hippuric acid on the concentration of toluol in the inspiration air influenced by the respiratory minute volume was shown. It is concluded that the estimation of the hippuric acid from a one- to two-hours' collective urine of the working shift may give actual references to the toluol load. The increase of hippuric acid in the urine of 1.5 g/l after toluol exposition refers to the transgression of the MAK-values according to TGL 22310.

Air Pollutants↗
PubMed1980

[Cardiac x-ray findings and vascular calcification in arterial obstructive disease in the pelvic and leg region. II].

In 117 patients with arterial obstructive disease in the region of pelvis and leg compared with test persons with healthy vessels the percentage of the deformation of the heart according to the classification after Richter was significantly higher for the left-side prevailing bilaterally loaded heart as well as for the left-ventricularly loaded heart. No differences could be ascertained between hypertonic and normotonic patients with ill vessels. In the patients compared with the clinically healthy test persons we registered surface-kymographically and electrokymographically more frequently a pathological marginal movement of the heart as a reference to a myocardial dysfunction. The distinct pathological surface-kymographical and electrokymographical findings on the heart correlated with the electrocardiographical findings. The data got on the heart confirmed the indication of a cardial basal therapy existing in most cases in older patients with vascular diseases. The slight diameter of the thoracic aorta as well as the restriction of the surface-kymographically provable amplitude of the movement in the region of the arc may, compared with the test persons with healthy vessels, refer to a disturbed wind kessel function of the aorta, they let us think of a primary rigidity of the wall. On the basis of the present results of examinations the sum of simply to be established X-ray findings--form of the heart, measure of the aorta, state of sclerosis, surface-kymographical findings at the heart and the aorta--may characterize an advanced vascular disease.

Angiography↗
PubMed1980

[Cardiac findings and vascular calcification in arteriosclerotic obstructive disease in the pelvis and leg region. I].

In 117 patients with angiographically ascertained arteriosclerotic obstructive disease in the region of pelvis and leg the smoking of cigarettes in a high degree confirmed itself as atherogenic factor of risk. The rate of hypertension of patients with vascular disease was increased in comparison with the average population. In contrast to a control group of test persons who after clinical angiological examination did not give a clue to a vascular disease the patients with vascular diseases shows a significantly higher percentage of radiologically visible calcifications in the region of the abdominal aorta, the iliacal and the peripheral arteries of the legs. The calcification of the vessels were generalized in 85%. Apart from the calcification of the abdominal aorta the sclerosis was visible above all in the vascular are switched after the obstruction. There were no differences between normotonic and hypertonic patients with vascular diseases concerning the state of sclerosis. Clear correlations between the proof of sclerosations of the vessels and the apparative angiologically measurable narrowing of the vascular system are not known. Nevertheless in our opinion the calcification of the arteries of the legs in younger patients may be regarded as a reference to a disturbance of the arterial blood supply which must be clarified. The densitometrically established content of calcium salt in the calcaneus showed a dependance on the formation of collaterals and the state of sclerosis in the corresponding type of obstruction and may give a quantitative measure for the degree of severity of an ischaemic osteoporosis.

Age Factors↗
PubMed1980

[Urinary fluoride excretion as proof of exposure in welding with lime electrodes].

In a model experiment 8 test persons each were given 1 mg and 2 mg fluoride per os. In a subsequent period of urine collection of 4 hours on an average 10% of the adduced fluoride were eliminated. Taking into consideration extraprofessional intake of fluoride may be concluded that the estimation of fluoride in the urine of welders working with Kb-electrodes may give references to the individual load of the respiratory tract by weld fumes.

Calcium↗
PubMed1980

[Effect of varicose vein sclerotization on the venous hemodynamics of the lower extremities].

Plethysmographic examinations on 47 females with slight primary varicosis to primary varicosis of medium degree resulted in excessive values of the swelling inclination and the change of the venous capacity V30 compared with the normal values reported in literature, whereas the venous regurgitation was in the superior normal region. By sclerosation treatment no significant change of the pathological venous measuring values could be achieved. In a good cosmetic success and directed influence of the locally disturbed haemodynamics could, therefore, not be spoken about the restoration character of the sclerosation treatment for the disturbed venous haemodynamics.

Adult↗