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Biomedical subjects

H Voigt

Publications and source records attributed to H Voigt.

At least 109 records · Page 6Linked to original sources
PubMed1980

[Prophylaxis of thrombosis in surgical gynecology and obstetrics (author's transl)].

An account is given of possible approaches and means available today to cope with physical and medicamentous prophylaxis of thrombosis in gynecologico-obstetric practice. Literature is evaluated, and preference is given to methods which have been safely established by verifiable diagnostic techniques as being applicable to prophylaxis of thrombosis. Due consideration is given to individual inclinations to thrombosis and haemorrhage. Therefore, emphasis is laid on low doses of heparin or dextran.

Adult↗
PubMed1980

[Gynaecological and obstetric operations in coagulative disorders (author's transl)].

Evaluated in this paper are 16 gynaecological operations which had been performed on 14 women for haemostatic disorders, between 1973 and 1979. Von Willebrand's disease had been recorded from ten patients, thrombocytopenia from two, and hyperfibrinolysis from another two. Haemorrhagic complications were observed in six cases, although specific haemotherapy had been applied to them. - Twelve analysable courses of labour of patients with known coagulative disorders were recorded from among those who had been under obstetric care, between 1963 and 1979. Two of the above three diseases ranked high on the list again, with von Willebrand's disease being diagnosed in six cases and thrombocytopenia in four. Hyperfibrinolysis was recorded from one patient and an unelucidated plasmatic coagulation disorder from another one. All twelve women had spontaneous deliveries without complications. Foetal death had occurred in two women with thrombocytopenia, prior to their admission to hospital. One of the deaths had been caused by umbilical cord strangulation. Secondary haemorrhage was observed in two cases, both late in the puerperium. - Diagnosis and therapy are discussed. Cases of the above kind should be treated in clinical centres staffed with experienced personnel.

Adolescent↗
PubMed1980

[Coagulation disorders in obstetric patients at gynaecological hospital of Leipzig University, 1961 through 1978 (author's transl)].

Intrapartum coagulopathy was secured from 41 in 69,336 obstetric patients, between 1961 and 1978. Haemostatic disorders, such as v. Willebrand-Jürgens syndrome, idiopathic thrombocytopenia, plasmatic coagulation defects, and hyperfibrinolysis, had been recorded from ten patients even before parturition. The courses of pregnancy, childbirth, and puerperium of those patients are reported, with reference being made to the need for prepartum hospitalisation as well as for target-oriented substitutional therapy and non-invasive delivery control. - Acute intrapartum haemorrhagic syndrome occurred to 31 patients, among them 13 patients with loss coagulopathy. Prophylaxis and therapy of such coagulation disorders are discussed. The deaths of two mothers are analysed. Consumptive coagulopathy, triggered by typical gestational complications, was manifest in the other 18 patients. Prophylaxis and therapy of that severe obstetric coagulopathy are discussed.

Adult↗
PubMed1979

[Autoantibodies in arteriosclerosi and endangiitis obliterans].

10 of 14 patients with obliterating endangiitis and 2 of 17 patients with obliterating arteriosclerosis had in the serum immunoflorescence-optically provable low titre antibodies against different constituents of smooth musculature (once cross-reacting with transverse and cross striation of the myocardium). Further antibodiies against brush border of proximal renal tubuli, parietal cells, cardiac sarcolemma, cytoplasm of the liver and distal renal tubuli were found. Antibodies against nuclear material, skeletal musculature, further typical antibodies against mitochondria, ribosomes and membranes of the endoplasmatic reticulum as well as so-called pemphigus and pemphigoid antibodies could not be proved. The proof of low titre antibodies against constituents of smooth musculature is in this case regarded as an unspecific marker of an (often) viral inflammation.

Arteriosclerosis Obliterans↗
PubMed1979

[Morphologic studies on in experimental lung transplantations. II. Light microscopic and histochemical findings in the transplanted homologous dog lung].

Morphologic Studies (light-microscopy, enzyme histochemistry, semi thin-layer preparation) on homografted canine lungs with and without immuno-suppressive therapy (Azathioprin, resp. anti-thymocyte serum) reveal different findings from untreated control animals and those after immuno-suppressive treatment. Under Azathioprin as well as anti-thymocyte serum the signs of rejection are attenuated, and regular pulmonary tissue is maintained in larger areas. Damages of certain cellular elements are better ascertained by means of determination of specific enzymes activities than by help of light-microscopic methods.

Animals↗
PubMed1979

[Contribution to the spontaneous pneumothorax from the surgical point of view (author's transl)].

The number of patients with spontaneous pneumothorax has increased in the last years. Above all young asthenics, often very tall, are affected. Smokers seem to be more endangered due to their cough-attacks in the morning. Beside them also patients with traumatic or iatrogen pneumothorax were more frequently seen. The therapy of the different form of pneumothorax is becoming more and more a surgical one, thus shortening the treatment time and diminishing the rate of recidives. In the first attack thorax-drainage is preferred; the second stage of therapy in the case of recidiv-pneymothorax is the thoracotomy. The so-called "idiopathic-spontaneous pneumothorax" which is to be seen in young people, is very seldom.

Adult↗
PubMed1979

[Contributions of thoracic surgery in the Research Institute for Pulmonary Diseases and Tuberculosis since its founding and under the presence conditions in the treatment of specific and nonspecific lung diseases (author's transl)].

Thoracic surgery is done in the Research Institute for Pulmonary Diseases and Tuberculosis for about 25 years. 2463 lung resections on account of tuberculosis, 934 lung resections on account of intrathoracic tumors, among them 795 suffering from bronchial carcinoma, 422 operations because of nonspecific pulmonary diseases (bronchiectasis, lung abscess a.s.o.) and nearly the same number of operations because of spontaneous pneumothorax were performed in this time. Cystic lung disease, bullous emphysema, pulmonary mycosis and diseases of diaphragm and oesophagus were rarer indications for surgery. Since 1970 an increasing number of thoracic injuries by accidents were treated (70 patients). At the beginning collapse therapy (1953/54) was still in use (305 operations). In all the number of great thoracic operations 1978 was 5417. Besides, experimental investigations dealing with lung transplantation were done in dogs. These results are published in several papers. The technical experience gained by this research work could be utilized for clinical practice.

Bronchial Neoplasms↗
PubMed1978

Experimental anastomosis between the parenchyma of spleen and kidney.

The procedure described using UV-irradiation and surgical removement of the renal capsule leads to the development of anastomoses between the spleen and the kidney. The collaterals are able to divert blood from the portal system to the surface of the kidney and then to the renal vein and the iliac veins systems. The procedure is easily performed and well tolerated.

Animals↗
PubMed1977

[Reversal of small bowel segments to delay intestinal passage after total colectomy (author's transl)].

Five female mini-pigs underwent total colectomy including resection of the ileocecal valve. Sparing the terminal rectum, we reformed an end-to-end anastomosis between terminal ileum and remaining rectal cuff. In a second series 8 female mini-pigs have been colectomized using the same model. To delay intestinal passage, in addition a 10-12 cm long reversed segment of terminal ileum has been inserted between small bowel and rectal stump. Both groups were compared with a group of normal unoperated mini-pigs in a study up to 1 year, observing intestinal transit time, blood chemistry and general development of the animals. It could be proved that the reversal of a small bowel segment in colectomized animals leads to a prolongation of the intestinal transit time, to normalization of electrolytes and general appearance. Colectomy was only survived by animals with a reversed segment. The clinical application of a reversed small bowel segment following total colectomy in 1 patient was successful.

Adult↗
PubMed1977

[Morphological studies of experimental lung transplantation. I. Light microscopic and histochemical findings in autotransplants of dog lungs].

Morphological investigations (light microscopy, semithin sections, histochemistry) on autografted lungs showed two changes with mifferent regional distributions. In the upper lobes were found focal areas of slight fibrosis, in the upper and lower lobes degenerative changes especially of the small bronchi and bronchioles with a focal loss of activity of alkaline phosphatase, nonspecific esterase and some dehydrogenase. Possible reasons for these morphological changes are discussed in connection with functional and biochemical results.

Acid Phosphatase↗
PubMed1977

[Experimental lung transplantation at the Research Institute for Lung Diseases and Tuberculosis Berlin-Buch. Technical standard and quality].

Report on the technical standard of unilateral orthotopic allogenic lung transplantation (allo- or homotransplantation) which has been developed and tried on animals since years at The Institute for Research on Pulmonary Diseases and Tuberculosis in Berlin-Buch. Technical insufficiencies which are crucial for essential alterations of the graft in autogenous lung transplantation (replantation) can not be excluded in allogenic transplantations also. By means of certain direct and indirect criteria the authors examined the development of quality of the technical standard between the years 1973 and 1976. Only based on optimal technique the results from examinations of recipient and graft can be correctly valued. On the other hand, optimal technique is an indispensable presupposition for optimal efficiency of several immunosuppressive methods. Duration of anesthesis, operation, ischemia of the transplantate, and of atrial, arterial, and bronchial anastomosis are considered for the assessment of the quality of technical standard. Thrombosis of pulmonary vein and of atrium was the most frequent complication in 71 allogenic pulmonary graftings. Their frequency decreased with improved technical skill, but some circumstances suggest that their formation is favored also by other factors. The duration of survival after unilateral allogenic lung transplantation is reported, although this is no direct scale for the technical performance.

Animals↗
PubMed1977

[The thoracic radiographic picture in routine monitoring following unilateral allogenic lung transplantation in the dog].

Undesired effects of nonspecific immunosuppression may be delimited by individual dosage. Early recognition of allograft rejection is the presupposition for that steering. As long as immunologic test methods require a great expense of equipment, personnel, and time, and as other methods (bronchospirometry, lung puncture) after lung transplantation additionally endanger the recipient, clinical routine examinations are particularly important, primarly thorax x-ray examinations. The authors report on serial chest radiographs during the courses after 71 unilateral orthotopic allogenic pulmonary transplantations in dogs with regard to the findings at obduction. Possibilities of differential diagnosis shall be found by that, and the limits of interpreting x-ray films after lung transplantation shall be disclosed. Certain distinctive marks in the x-ray findings indicate the various possible complications; they can not be relied upon, however, when they only extend to the graft (hemorrhage, infection, rejection).

Animals↗
PubMed1977

[Indication of tracheotomy after lung resection (author's transl)].

Today tracheotomy is not often performed after resction of the lung. This is caused by better postoperative care and also by the well known complications following tracheostomy. Indications for tracheostomy are as follows: 1. The necessity for long term ventilation.--2. The necessity to perform bronchus-toilet in short intervals in patients unable to cough.--3. In patients with respiratory insufficiency after pneumonia or other reasons.

Humans↗
PubMed1976

[Feulgencytophotometric DNA distribution patterns of well-differentiated (mature) and undifferentiated (less mature/immature) forms of primary skin-reticulosis].

33 tissue sections of cases of primary skin-reticulosis showing different degrees of maturity were analysed by means of Feulgen-cytophotometric methods in regard to their DNA-content. The measurements performed disclosed cytophotometric differences of DNA distribution patterns between mature and less mature/immature forms: Mature forms of reticulosis were characterized by predominantly diploid DNA distribution patterns, whereas less mature/immature forms showed a main distribution in the hyperdiploid-hypotetraploid range respectively atypically dispersed aneuploid values with increase of variation and mean DNA-content. Moreover in several cases distribution patterns were seen, which may be regarded as cytophotometric transition forms showing a diploid peak and a higher rate of cells with enhanced DNA-content. Those cases appeared histomorphologically mature with a slight tendency to immaturity.

Cell Differentiation↗