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Biomedical subjects

H Ueda

Publications and source records attributed to H Ueda.

At least 883 records · Page 49Linked to original sources
PubMed1981

Cardiac death and myocardial lesions in non-stroke SHRSP under specific pathogen-free system.

The most remarkable finding in SHRSP with cardiac death under specific pathogen-free system was idiopathic diffuse fatty degeneration of the myocardium. Besides fatty degeneration, diffuse myocardial fibrosis and scattered infarction were observed. In male rats the incidence of cardiac death increased with each generation. Therefore, this myocardial degeneration seemed to be hereditary disorder. The SHRSP with cardiac death seemed to be a new type of SHR, namely Heart-Prone SHR (SHRHP). SHRHP may be a kind of animal model for congestive cardiomyopathy (COCM) in human beings.

Animals↗
PubMed1981

Effects of combination treatment with vitamins E and C on chloasma and pigmented contact dermatitis. A double blind controlled clinical trial.

A multi-clinical double-blind study on therapeutic effect of combination preparation of vitamins E and C was undertaken in comparison with single preparation of vitamin E and vitamin C in the treatment of chloasma or pigmented contact dermatitis (PCD). Combination treatment resulted in significantly better clinical improvement than vitamin C alone in both diseases. Objective data compiled from color difference measurements and color photographs revealed significantly better results with combination treatment in chloasma than vitamin C alone and, in PCD, than vitamin E or C alone. Differences in skin luminosity between hyperpigmented and normal areas significantly decreased in all three groups, with the combination group producing the most significant change. The total serum lipoperoxide level and its ratio to total serum lipids tended to decline in the combination group, and decreased significantly in vitamin E group. The sebum lipoperoxide level decreased significantly only in the combination group (EC).

Ascorbic Acid↗
PubMed1981

Study on erythrocyte lipids and osmotic fragility in elderly people with anemia.

Hospitalized aged patients suffering from a sequelae of cerebral vascular disorders accompanied by anemia were studied to clarify the relationship among the osmotic fragility of red blood cells, plasma lipids and the phospholipids fraction of erythrocytes. As a result, with a decrease in hemoglobin (Hb) concentrations, each lipid fraction of plasma decreased remarkably and the phospholipid composition ratio of erythrocytes was disturbed. In accordance with the fluctuation of the lipid fraction of erythrocytes, increases in osmotic fragility of erythrocytes and in resistance to osmotic lysis were observed.

Age Factors↗
PubMed1980

The effects of retinoids on proliferative capacities and macromolecular synthesis in human breast cancer MCF-7 cells.

The effects of various retinoids on the proliferative capacities and on the synthesis of DNA, RNA, and protein have been investigated in MCF-7 mammary carcinoma cells in culture. Of the various retinoids tested, retinoic acid revealed maximum activity in inhibiting cell proliferation and thymidine incorporation. The degree of inhibition of cell proliferation by the various retinoids paralleled their capacity to inhibit thymidine incorporation, suggesting suppression of DNA synthesis as a primary cause of restriction of cell growth by these compounds. Two nonepithelial human cell lines were tested for sensitivity to retinoids, and showed diminished responses compared with MCF-7 cells. This suggests a correlation between the ability of retinoids to exert control of differentiation and cell proliferation for a given cell type. Reversibility of the effect of retinoid treatment, high cell viability, and lack of retinoid-induced lysosomal enzyme release, as shown in our studies, indicate that cytotoxicity may be excluded as a cause of decreased cell proliferation and inhibition of thymidine incorporation by retinoids.

Breast Neoplasms↗
PubMed1980

Regional distribution of a novel analgesic dipeptide kyotorphin (Tyr-Arg) in the rat brain and spinal cord.

Using high performance liquid chromatography, we measured kyotorphin content in discrete regions of the rat brain and spinal cord in an attempt to clarify its physiological significance. Higher concentrations of the dipeptide were found in the midbrain, pons plus medulla oblongata and dorsal cord, which are the most sensitive sites for the microinjection of morphine and/or electrical stimulation-induced analgesia. Kyotorphin may play a physiological role in pain control in the central nervous system.

Animals↗
PubMed1980

A study of three-dimensional image expression of the left ventricle.

In this report, the left ventricular blood pool of the heart is presented as an image of three dimensions by collecting the data simultaneously with two scintillation cameras from two directions at right angles to one another and processing by a computer system. Our three dimensional procedures, quite different from the conventional two dimensional images, reproduce the cubic structure of the left ventricle. It was confirmed by basic experiments using several phantoms that this three dimensional image reproduced the shape of the object very accurately. The three dimensional images of the left ventricle clearly showed morphological changes and abnormalities in myocardial movement. It is highly valuable in diagnosis because foci of myocardial infarction, akinesis and dyskinesis are clearly detected by this technique. In particular, the fact that the three dimensional images conform well with X-ray cineangiography and 201T1 scanning justifies the value of the clinical application of this technique.

Angina Pectoris↗
PubMed1980

Residual effects of hypnotics: triazolam, flurazepam, and nitrazepam.

The residual effects of three hypnotics were investigated by the method of 24-h polygraphy (EEG, EMG, and EOG). The drugs were triazolam 0.25 mg and 0.5 mg, flurazepam 15 mg and 30 mg, nitrazepam 5 mg and 10 mg, and placebo. The subjects were healthy volunteers, eight men and eight women with an average age of 34.3 years. The number of total polygraphic records was 77. Triazolam 0.25 mg and 0.5 mg, flurazepam 30 mg, and nitrazepam 10 mg showed definited sleep inducing and sleep maintenance effects in night recordings. Flurazepam 15 mg and 30 mg and nitrazepam 5 mg and 10 mg were followed by residual effects in morning, afternoon and evening recording periods on the day after the administrations of the hypnotics. However, no effects were seen on the day after the administration of triazolam 0.25 mg and 0.5 mg except for some slight residual effects in the morning. Thus triazolam 0.25 mg and 0.5 mg produces less residual effect than do flurazepam 15 mg and 30 mg, and nitrazepam 5 mg and 10 mg, and 24-h polygraphy is useful for measuring the residual effects of hypnotics.

Adult↗
PubMed1980

[Methods for intravenous injection and blood collection in the guinea pig via veins of the forelimb without anesthesia (author's transl)].

Methods for intravenous injection and blood collection by way of the forelimb in guinea pigs without anesthesia were investigated, with the results as follows: 1) Both the accessory cephalic and cephalic veins were found available for injection as well as for drawing blood samples. Venipuncture was accomplished with greater ease by using the accessory cephalic vein. 2) The following procedure has proven practical. (i) Clip the hair over the site. (ii) Restrain the animal to immobilize the foreleg in slight extension by grasping it at the elbow joint with the thumb and forefinger over its dorsal and ventral aspects, respectively. (iii) After disinfecting the skin surface with alcohol, perform injection using an appropriate syringe with a 27 (1/4) or 25 (1/3) gauge intravenous needle, or puncture the vein with a 23 (1/2) gauge i. v. needle to collect the blood that drips out.

Animals↗
PubMed1980

Immunochemical quantitation of serum complement components in SFD and AFD infants.

Components of complement (protein concentrations of C1q, C3, C3-activator, C4, C5 and C9 and whole complement (hemolytic activity)) were measured in sera from full-term small-for-date (SFD) and appropriate-for-date (AFD) infants and their mothers. (1) Half the SFD infants showed lower C1q levels than the AFD infants. (2) SFD infants showed the same levels of C3 as AFD infants. (3) Although SFD infants showed slightly higher levels of C3-activator than AFD infants, there was no significant difference. (4) SFD infants and AFD infants showed the same level of C4. (5) With respect to C5, half the SFD infants showed lower levels than the AFD infants. (6) Levels of C9 in the SFD infants were essentially the same as those in the AFD infants. (7) The amount of protein in every complement component of an infant was smaller than that of the mother. In AFD infants, the infant-maternal ratios were 0.64 for C1q, 0.45 for C3, 0.29 for C3-activator, 0.43 for C4, 0.54 for C5 and 0.12 for C9. (8) The whole complement titers of umbilical cord sera from the AFD infants were approximately one half of those of the maternal sera. This is due to the smaller amount of complement protein itself in the infant sera. (9) The whole complement titers of umbilical cord serum agreeably correlate with gestational weeks and birth weight of the infants. (10) The whole complement titer in full-term SFD infants was lower than that in normal full-term AFD infants.

Complement C1↗