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Biomedical subjects

H Tajima

Publications and source records attributed to H Tajima.

At least 145 records · Page 8Linked to original sources
PubMed1986

[Effects of cisapride on lower esophageal sphincter pressure and gastroduodenal motor activity in man].

Manometric study was performed to investigate the effects of cisapride, a new non-antidopaminergic gastrointestinal prokinetic compound, on interdigestive lower esophageal sphincter pressure (LESP) and gastroduodenal motility using infused catheter technique. The subjects consisted of 9 healthy volunteers and 29 patients with progressive systemic sclerosis (19), reflux esophagitis (8) and others (2). 4 mg of cisapride was given by bolus injection, continuous infusion or oral administration. The following results were obtained: Intravenous and oral cisapride increased LESP compared with basal pressure. Especially, bolus injection of cisapride caused a significant elevation of LESP during 30 minutes after administration. After administration of cisapride, gastroduodenal motility was accelerated gradually, then inducing IMC-like contractions. By bolus injection, IMC-like contractions were induced in healthy subjects more frequently than in patients group. On the other hand, motility index of stomach and duodenum showed persistent increase in patients group compared with healthy subjects. Cisapride-induced IMC-like contractions initiated from LES and upper part of stomach and mediated to duodenum, though aborad migration was not confirmed in the present study.

Adolescent↗
PubMed1985

Nonsecretory myeloma: analysis of two patients by immunoperoxidase studies and plaque-forming cell assay.

We studied the production and secretion of immunoglobulin by tumor cells in two patients with nonsecretory myeloma, by means of an immunoperoxidase technique and plaque-forming cell assay. Immunoperoxidase staining of bone marrow cells revealed monoclonal proliferation of immunoglobulin-containing cells, and the plaque-forming cell assay of peripheral mononuclear cells and bone marrow cells showed secretion of monoclonal immunoglobulin from the myeloma cells. These observations suggest that the secreted protein disappears as a result of enhanced catabolism or rapid deposition. There has been speculation as to the existence of this type of nonsecretory myeloma, but there had been no evidence. We were able to demonstrate it with the plaque-forming cell assay.

Aged↗