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Biomedical subjects

H Tajima

Publications and source records attributed to H Tajima.

At least 163 records · Page 9Linked to original sources
PubMed1984

[Comparative study on the inhibitory effect of glucagon and secretin on the gastroduodenal motility in man].

Manometric study was performed to compare the inhibitory effect of glucagon and secretin on the gastroduodenal motor activity by infused catheter method. The subjects consisted of 3 healthy volunteers and 7 patients with peptic ulcer and other diseases. The following results were obtained. After the intravenous administration of glucagon (1 mg), the motor activity of the stomach and duodenum was inhibited promptly. According to statistic evaluation, the contraction numbers and motility index decreased significantly during 25 minutes compared with the basal values in both stomach and duodenum. After the administration of secretin (100 units), gastric motor activity was markedly inhibited, although duodenal motility increased during 10 minutes due to the initiation of secretin-induced migrating motor complex. The contraction numbers and motility index in stomach decreased significantly during 20 minutes after the administration. The inhibitory effect of glucagon was more remarkable in duodenum than in stomach. On the other hand, secretin was more effective in stomach than in duodenum.

Adult↗
PubMed1984

[Significance of anti-HBc IgM in acute hepatitis and hepatitis B associated chronic liver disease].

To determine the diagnostic value of anti-HBc IgM in acute viral hepatitis or chronic liver disease B, Anti-HBc IgM was measured by a RIA and an ELISA in 32 patients with acute hepatitis (4 with type A, 15 with type B and 13 with type non A non B), 18 patients with chronic hepatitis and 19 patients with liver cirrhosis. In acute hepatitis B, anti-HBc IgM (both RIA and ELISA) was positive in 14(93%) of 15 patients and its cut-off index value was very high. However, anti-HBc IgM was always negative in one patient with typical course of type B. In 1 of 4 patients with acute hepatitis A and 2 of 13 with non A non B, anti-HBc IgM (RIA and/or ELISA) was positive. These 3 patients were positive for anti-HBs at the onset of disease, so we could not made the diagnosis of acute hepatitis B. Anti-HBc IgM was positive in 21(51%) of 37 patients with HBsAg-positive chronic liver disease by RIA and in 11 (30%) by ELISA, and its cut-off index value was relatively low. These results suggest that when adequate cut-off index value is established, anti-HBc analysis is useful for differentiating recent and current infections from remote infections.

Acute Disease↗
PubMed1984

Clinical significance of serum alpha-fetoprotein in patients with liver cirrhosis.

The clinical significance of serum alpha-fetoprotein (AFP) was studied in 114 patients with liver cirrhosis, who were followed for more than one year. Out of 114 patients, serum HBs antigen (HBsAg) was positive in 49 (43%). The mean follow-up period was 4.3 years (from 1 to 13 years). Serial determinations of AFP by RIA were performed once a month in all patients. The pattern of serial changes of AFP levels could be divided into three characteristic types: 1) fluctuation of AFP levels to greater than 20ng/ml was observed in 39 cases (Type I); 2) a transient rise of AFP levels to greater than 50ng/ml was observed in 20 cases (Type II); 3) in the remaining 55 cases, AFP levels were always less than 20ng/ml. During the follow-up period, liver cell carcinoma (LCC) developed in 29 cases (25%) and hepatic failure in 11 cases (10%). The incidence of LCC was significantly higher in Type I (18/39, 46%) than in Type II (3/20, 15%) and Type III (8/55, 15%). It is concluded that cirrhotic patients with fluctuation of AFP levels should be included in the high-risk group for LCC.

Adult↗
PubMed1983

[Evaluation of chemotherapy in hepatocellular carcinoma with liver cirrhosis].

The present paper discusses the efficacy of cancer chemotherapy in 46 patients with advanced hepatocellular carcinoma. In most of patients, Adriamycin (20-40 mg) or Mitomycin C (20 mg) was given by one shot injection via the hepatic artery and followed by serial administration of anticancer agents such as 5-fluorouracil (300-750 mg/day), Adriamycin and Toyomycin. Results were as follows: 1) The complete response was not seen. 2) The partial response (more than 50% decrease of the tumor size) was observed in 6 of 46 patients (13%) for 34 to 457 days. 3) Absence of tumor thrombi in the portal vein which was observed by hepatic angiography, CT and ultrasonography, was closely correlated in the partial response and the prolongation of survival time. 4) There were no significant differences with the therapeutic response or survival time among 3 groups (E2: tumor occupation rate (TOR) 20-40%, E3: TOR 40-60%, E4: TOR above 60%). 5) Obstinate abdominal pain and abnormal liver function remarkably were improved during the chemotherapy in 11 of 18 cases (61%), and 6 of 46 cases (13 %), respectively. 6) Major causes of death were hepatic failure (45.7%), gastrointestinal bleeding (30.4%) and intra-abdominal rupture of the tumor (14.7%). 7) As side effect, some extent of hematopoietic suppression was observed in 25% of the patients treated.

Adult↗
PubMed1981

Standard blood pressure curves of schoolboys and schoolgirls in Akita prefecture.

Blood pressure of 251,742 schoolboys and schoolgirls aged 7 to 18 years was measured in the year 1970. Analyzing these data, the authors obtained the percentile values classified by age. The lowest hypertensive systolic blood pressures, which are represented by the 95th percentile, are 123, 126, 128, 128, 129, 134, 138, 144, 149, 152, 155, and 154 mmHg in boys from 7 to 18 years of age, respectively. The corresponding values are 123, 126, 128, 130, 134, 138, 139, 143, 144, 142, 142, 141 mmHg in girls of the same ages. Girls' systolic blood pressure is higher than that of boys between the ages of 10 and 13 years. After the 14th year of age, girls' systolic blood pressure does not increase any further, whereas boy's blood pressure continuously increases until 18 years. The present results differ in the following two points from the study in USA (1977): 1) The uniform rise of blood pressure with age is not observed. 2) Blood pressure, especially systolic pressure, is higher in girls than in boys between the ages of 10 and 13 years, although it is higher in boys thereafter until 18 years.

Adolescent↗