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H Stobbe

Publications and source records attributed to H Stobbe.

At least 55 records · Page 3Linked to original sources
PubMed1981

[Risk factor benzene (author's transl)].

Nearly one hundred years ago clinical and epidemiological studies have already assigned benzene as a markedly haematotoxic substance. Nowadays benzene is known as an important professional noxa, which is straight off directed against the haematopoietic system, essentially to a dose-time-effect. By this it can be taken as a model also for other noxious substances. Similar solvents often contain so-called "hidden benzene", that means not declared benzene, so that the consumer don't know what dangerous substance are available for his personal use. Impairment caused by benzene mostly are manifested earliest after months, years or for tens of years, and the point is, that these haematopoietic disorders are irreversible disturbances of the haematopoietic stem cell compartment. The consequence of this fact is a deep involvement of the proliferation of the erythro-, mono-, granulo- and thrombopoietic cell lines, mostly with the predominance of one of these myeloproliferative cell systems. In the further progression of the impairments due to benzene three different clinical pictures can be observed: the aplastic bone marrow syndrome (i.e. aplastic anemia), the haematopoietic dysplasia (i.e. preleukemia) and the acute leukemias (with the subtypes erythroleukosis, myeloblastic-promyelocytic or myelomonocytic from respectively). Also the transition from one clinical picture to another is possible.

Anemia, Aplastic↗
PubMed1980

[Hematotoxic lesions caused by non-steroidal antirheumatic agents].

Among the lesions of haematopoiesis conditioned by medicaments the lesions by non-steroidal antirheumatic drugs occupy the first place. They get their significance by the fact that they are not so infrequently irreparable and thus show an unfavourable prognosis. On principle in pathogenetic respect lesions by immunologic reactions which vastly do not depend on the dosage, are to be demarcated from the toxically conditioned side-effects which depend on dosage. Conditioned by drugs aplastic syndromes of the bone marrow are not in every case strongly depending on dosage. For this is to be assumed an individual, particular sensitivity of the haematopoietic stem cells (stem cell defect). Of the anti-rheumatic drugs used for the basic therapy chloroquine derivations, gold, D-penicillamine, immunosuppressives and levamisol may effect disturbances of the haematopoiesis, for which facts are examples are given. This concerns also the symptomatically acting antirheumatic drugs. An overestimation of rare side-effects of drugs should not block the application of certain medicaments, however, they should be given only in such a high dosage as it is necessary. In combinations of antirheumatic drugs every individual drug is considered as causative factor. Interactions are particularly be taken into consideration. Control programmes, particularly with certain laboratory parameters, give the early recognition of side-effects and render possible to avoid severe effects.

Adult↗
PubMed1980

[Nosology of myeloproliferative disorders].

A nosological description of the myeloproliferative diseases has to demonstrate the characterizing features of the various entities as well as their common characteristics and peculiarities. Here it becomes evident that one must differentiate between diseases with neoplastic proliferation of above all one series of cells (pure cell proliferation) and such one with two or more series of cells (mixed cell proliferation). Transitions from pure cell forms to mixed cell forms and change of the prevailing cell series in mixed cell proliferations, respectively, may be expected like certain terminal results (blastic transformation, myelofibrosis). The proposition of an improved classification demands a correct cytological, cytochemical and histological investigation of the bone marrow as well as repeated analyses of the course.

Bone Marrow Cells↗
PubMed1979

[Simple diagnosis of diabetic microangiopathy by means of the tourniquet test].

The pathological results of the tourniquet test after Rumpel-Leede by the establishment of a decreased capillary resistance refers to the presence of a microangiopathy in diabetics and by its rapid and simple performance is suitable for the preliminary diagnostics, in order to judge the conditions of microcirculation. The longer the diabetes exists the oftener a pathological result is found in the tourniquet test. The form of therapy as parameter for the severity of the disease shows a direct relation to the accumulation of pathological findings of capillary resistance. In diabetic hypertensive patients regularly a pathologically decreased capillary resistance is to be found.

Adolescent↗
PubMed1979

[Determination of capillary lesions during diagnosis by means of the tourniquet test of microangiopathies in diabetes mellitus].

Decreased capillary resistance is documented by a pathologic tourniquet test (Rumpel-Leede), which demonstrates the existance of microangiopathy in diabetics. Thanks to its simple and rapid execution the tourniquet test is suitable for early diagnostic assessment of the situation in the microcirculation. The longer the patients have had diabetes, the more frequently is the tourniquet test pathological. There is also a direct correlation between the type of therapy (as an index of the severity of the disease) and the accumulation of pathologic results in measurement of capillary resistance. In diabetics with hypertension, capillary resistance is always decreased to a pathologic degree.

Capillary Resistance↗
PubMed1979

[Granulocytes in the oral cavity (author's transl)].

The counting of the granulocytes in the oral cavity ("salivary corpuscles", orogranulocytes") gives an indication to the efficiency of the granulocytopoiesis, because there exist some analogies to the emigration of granulocytes into the tissue. Two different counting methods of the orogranulocytes, their normal values (which are in correlation to the number of teeth), the influence of local factors (like inflammations in the oral cavity), the values of orogranulocytes in myeloproliferative disorders and in agranulocytosis and granulocytopenia respectively are demonstrated. Furthermore the contributions deal with the values of the orogranulocytes during the therapy with glucocorticoids. The methods described are also suitable for the estimation of the efficiency of granulozyte transfusions.

Adolescent↗
PubMed1979

[Diagnosis of malignant lymphomas].

In the diagnostics of the malignant lymphomas is to be differed between the proper diagnosing, i. e. the morphological confirmation of the disease and the enlarged diagnostics which, after ascertainment of the histologicopathological findings and prior to the beginning of a therapy is necessary for the statement of the size of the spreading of the disease (classification of stages) as well as for the inclusion in group A or B and for the registration of the most different signs of activity. Swellings of the lumph nodes in adults should be clarified morphologically after three weeks, since only on this way an early diagnostics is guaranteed. In an unclear fever an abdominal lymphogranulomatosis is to be excluded. The explorative laparotomy and splenectomy is - if possible - to be performed before the beginning of a treatment. When pronounced signs of activity are present, however, a cytostatic treatment should precede this operation in order to decrease the risik of the operation. The classification in stages with exclusively clinical examination methods at present comprises a vast number, which in all stages must always be performed as an interdisciplinary task in a haematologico-oncological centre under control of an internist. The classification after Kiel of the non-Hodgkin-lymphomas does not only demand the knowledge of the nomenclature, but also the evaluation by the internist in order to perform the optimum therapy in these patients.

Humans↗
PubMed1978

[Methods and techniques of sampling and performing of cytologic lymph node smears (author's transl)].

Within the diagnostics of lymphoma the indication for cytodiagnosis and the coice of gaining material and its preparation (punction and exstirpation of lymph nodes with making smears in a squeezing manner to effect simulated tissue pattern) are the basis of an appropriate and effective work of the cytologist. The good diagnostic efficiency of the cytodiagnosis of lymph nodes is in no proportion to the totally insufficient application of those methods by physicians of various medical disciplines in the hospitals and outpatient departments. The lack of an adequate teaching of students and postgraduates is a main reason for the described situation. In order that each physician may have the possibility to apply the cytodiagnosis of lymph nodes within his diagnostic programms, some special references are given for the gaining and preparation of lymph node material.

Cytodiagnosis↗
PubMed1978

[Non-secreting plasmacytomas].

In non-secernent plasmocytomas there are no characteristic changes of serum protein. Diagnostic difficulties may be overcome by cytomorphological examinations, immunofluorescence and electron microscopy. By referring to 4 own observations the value of the electron microscopic characteristics of plasma cells is demonstrated. Subtile investigations in protein diagnostics are required for avoiding incomplete monoclonal immunoglobulins which may greatly enter the kidneys to be overlooked. Generally the prognosis of non-secernent plasmocytomas is not worse than that of other forms.

Aged↗
PubMed1977

[Bone-marrow insufficiency].

In a survey the definition of the notions insufficiency of the bone marrow, panmyelopathy, panmyelophthisis and aplastic anaemia, the subdivision into congenital and acquired forms as well as to the clinical course, the epidemiologic situation as well as the distribution according to age and sex are described. More in detail the author enters the etiological factors, in which cases the etiological classification of the individual case may be connected with considerable difficulties. Exogenic noxae are subdivided into factors dependent on dose and independent on dose as pathogenetic principles. In this connection professional noxious substances as well as unwished side-effects of medicaments are discussed more in detail. Despite all variety the possibilities of therapy are limited.

Adolescent↗
PubMed1977

[Standard methods in a hematologic laboratory--a prerequisite for an optimal diagnosis].

State of scientific knowledge and economic prerequisites determined the selection of the optimum methods for the necessary parameters in standardizing haematologic methods. Concerning the methods of counting, measuring and staining in the haematologic laboratory, we have to do above all with so-called conventional methods with an expenditure of work considerable in most cases. In the single steps necessary for obtaining a laboratory result the physician in a clinic or outpatient department essentially participates particularly in such cases when EDTA venous blood is applied. It is especially referred to the advantage of EDTA venous blood for taking blood samples for haematologic parameters compared with the taking of capillary blood which has a high rate of error. Apart from the common efforts of physicians in clinics or out-patient departments and laboratory physicians to obtain reliable results of the findings, the use of an improved technique (particle counters, dilutor, automatic picture analysis among others) as well as further proceedings of standardization (dye for panoptic staining and others) will achieve this aim.

Blood Cell Count↗