[Preleukemia: definition and laboratory-diagnostic criteria].
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Biomedical subjects
Publications and source records attributed to H Stobbe.
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In the form of a survey a report is given on the concept of the saliva corpuscle, its origin, composition, different degree of damage, its number and function. The quantitative behaviour enables a statement to be made about the actual unspecific cellular defence in parodontopathy (increased number of saliva corpuscles) and in various blood diseases (decreased number of saliva corpuscles. This has a particular diagnostic value.
In the diagnosis of Hodgkin's disease the histological investigation of the spleen, liver and abdominal lymph nodes in connection with exploratory laparotomy are necessary for staging and planning the therapy.
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The functional tests in form of tolerance tests allow an insight into the adaptibility of the organism to changed inner and outer conditions. The majority of haematological functional tests demands a temporary and economic expediture which excludes it a priori as screening test. According to a previously published phase program for the haematological functional diagnosis a report is given on simple methods for judging the disturbed partial functions of the blood.
A survey is given on the value of the haematologo-morphological examination methods, especially the differential counting of leucocytes, the smear of a concentrate of leucocytes and the cytomorphological judgment of the bone marrow. None of these methods is suitable for the search for cases in the sense of a preliminary diagnosis. This is also of importance especially for the differential counting of leucocytes. However, with aimed methods of proceeding these methods are of great diagnostic value, so that they may be very much in front in a graduated diagnostic program. The diagnostic evidence of a cytomorphological preparation of the bone marrow must highly be estimated concerning a situation of deficiency of iron, a diffuse or small nodular metastasizing of the bone marrow or lesion of the bone marrow by exogenic factors.
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