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Biomedical subjects

H Stobbe

Publications and source records attributed to H Stobbe.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Cytogenetic findings in acute myelogenous leukemias (FAB M 1 to M 6)].

The results published in the period from 1973 to 1983 entitled "Cytogenetic findings in acute myeloic leukemias" (M 1 to M 6 of FAB classification) were compiled. In 50-60 per cent of those patients affected with acute myeloic leukemia a deviating karyotype could be detected. With a markedly higher frequency chromosomes 8 and 21 will take part in aberrations, with translocations (8; 21) having the main share with about 30-40 per cent. More than half the male bearers of translocation exhibits a loss of the Y-chromosome, a third of female patients a loss of the X-chromosome. Trisomy 8 and 9 as well as monosomy 7 appear in about 20 per cent. These aberrations can also be found in all other leukemic and preleukemic processes. Patients with karyotypic abnormalities in all their cells will have the slightest average survival time and the worst appeal to therapy. The sole appearance of monosomy 7 or Ph1-chromosome respectively seems to be an unfavourable sign from a prognostic point of view. Children with acute myeloic leukemia will possess an aberrant karyotype more frequently than adults, but they have a longer average life, boys are more frequently affected by this. Acute promyelocytic leukemia can be characterized cytogenetically in 94 per cent of the cases by translocation (15; 17). However, distinct geographical differences can be observed here, the causes of which have not been elucidated. About 40 per cent of the patients with acute myelo-monocytic leukemia developed aberrations. Further investigations will have to show whether the chromosome 11 really took part in it somewhat more frequently than merely at random. Chromosome anomalies have not a visible influence on the course of the disease. In 30-40 per cent of patients with a rarely occurring acute monocytic leukemia, an abnormal karyotype could be found. There was an incidence of 47 per cent for a specific translocation (9; 11) or a similar variant respectively. Erythroleukemia is characterized by a high instability of chromosomes and karyotypical variability, particularly in erythrocyte precursors and by an average survival time of one months. Megakaryoblastic and eosinophilic leukemia are very rare kinds of acute leukemias. The small number of publications allows no general statement to be made concerning karyotypical changes.

Adolescent↗
PubMed1985

[Cytogenetic findings in chronic myelogenous leukemia].

Cytogenetic findings in chronic myeloic leukemia are represented in a survey. More than 90 per cent of CML are characterized by Ph1 chromosomes, with more than 90 per cent of the cases being involved in a translocation (9; 22). Further, non-incidental aberrations are +Ph1, isochromosome (17q) and +8 which particularly develop at the acute stage. Isochromosome 17q is assumed to be a marker for a straightly impending development of a blast crisis. Ph1-negative CML is connected with a comparatively bad prognosis for the patient. Partial trisomy 9q+ is indicated here as a marker chromosome. For the patient concerned congenital chromosome defects, such as the Down-syndrome, represent a higher risk of being affected with leukemia.

Adolescent↗
PubMed1985

Isoenzymes in plasma of acute leukaemia patients: prevention of anthracycline cardiomyopathy.

During the diagnosis and subsequent monitoring of patients with acute leukaemia, and of those with terminal blastic crisis in chronic myelogenous leukaemia, the activity of total LDH, ALAT, AP, ASAT as well as the isoenzymes LDH-H, LDH-M were measured in the plasma. Enzyme and isoenzyme activity of LDH, which differed in quantity at the various times of measurement, reflected the varying proliferation rate, depending upon the individual and upon the time of measurement and, consequently, the tumour cell mass.

Adult↗
PubMed1984

[Diagnosis and therapy of iron overload with desferrioxamine].

In polytransfused patients the diagnostics of the iron overload belongs to the strategic programme of the treatment. It is particularly referred to the value of the desferal test. In the therapy of the transfusion haemosiderosis desferrioxamine is the remedy of choice. Its at present most favourable form of application is the subcutaneous infusion by means of the infusion group. A success of the treatment is only to be guaranteed, when the therapy is consequently performed over years under balancing the iron supply and excretion.

Blood Transfusion↗
PubMed1984

[Comparative study of the efficacy of the DBVCy protocol (daunoblastin, bleomycin, vincristine, cytostasan) and the ABVD protocol in advanced Hodgkin's lymphoma. A prospective inter-clinic study within the framework of the Hauptforschungsrichtung Geschwulsterkrankungen].

In MOPP-resistant patients with Hodgkin-lymphoma stage III B and IV the well known ABVD-protocol was compared with the DBVCy-protocol (daunorubicin, bleomycin, vincristine, cytostasan) in a randomized prospective trial. 73 patients were evaluable, 35 received ABVD, 38 DBVCy. 4 out of 35 (11%) in the ABVD-group and 9 out of 38(24%) in the DBVCy-group reached complete remission. The median duration of the remission for DBVCy was 4,5 months, for ABVD 3,4 months (no significance). Median survivals (61 months in DBVCy and 37 months in ABVD) did not show significant differences; but the DBVCy-scheme seems to be better tolerabel. With the given evaluation can not be proved a difference between the two groups, but it is not likely, that one of the regimen is very much better or very much worse as the other.

Adult↗
PubMed1983

[Bone marrow capacity and reaction].

The formation of the blood cells leads via proliferation, differentiation and maturation processes, in which cases the bone marrow capacity expresses the functional capacity of this comprehensive system of cell renovation. Nowadays clues to the quantitative behaviour of proliferation of the various compartments (stem cell compartment, indicator cell compartment and morphologically characterizable cell compartment) are already existing also for man, in which cases various proliferation-kinetic tests give adequate informations. Via a quantitative determination of the granulocytes of the bone marrow an estimation of the postmitotic bone marrow storage of the granulocytopoiesis is at present possible. The responsiveness of the neutrophil granulocytes after stimulation (glucocorticoids, endotoxin) may be used in the clinic as bone marrow functional test with restricted statement. The diagnostic possibilities of the agar-colony-technique for the judgment of the bone marrow capacity are represented on the basis of an instance.

Adult↗
PubMed1983

[Risk of leukemia in aplastic anemias].

Nowadays an increased risk of leucaemia in patients with aplastic anaemias (insufficiency of the bone marrow) is regarded as certain. If the literature of the last 10 years is analysed, the data concerning a leucaemic transformation amount to values between 0 and 16%. Among our clinical material of 108 patients, 38 of them living, 10 patients (correspondingly 9%) showed a leukaemic transformation. The temporary latency between diagnosing of the aplastic syndrome and the leucaemic transformation was maximally 20 years. By cytomorphological investigations, particularly of the judgment of anomalies of erythroblasts, no certain prognosis concerning a possible development of leucaemia. Also cultivation methods of myelopoietic stem cells by means of diffusion chamber and agar culture technique do not seem to allow a certain evidence on prognosis.

Anemia, Aplastic↗
PubMed1983

[Cytogenesis and cytomorphology of the Hodgkin- and Sternberg-Reed cells].

As well the pathogenesis of the lymphogranulomatosis, the cytogenesis of the Hodgkin- and Sternberg-Reed-cells is still an unsolvable problem too. The priority in the discussion of this question have such hypothesis, in which a descend of these cells either from the lymphocytic or the monocyte-macrophage-system is important. The karyokinesis of the Hodgkin cells leads actually to the growth of the nucleus and the whole cell, but the formation of the Sternberg-Reed-cells in their property as gigantic cells means a "blind alley", connected with a blockade in their farther proliferation. The cytomorphology of the Hodgkin-cells and the causes for the formation of the Sternberg-Reed-cells with their multiform, partial bizarre nuclei will be discussed. In the consequence of anomalies of the mitosis, produced by so called disturbances of the spindle, several "partial nuclei" arise. These partial nuclei have the property to make partly a fusion together. In this connection the different shapes of the nuclei of the Sternberg-Reed-cells will be explained.

Cell Nucleus↗
PubMed1982

[Anthracyclin-cardiomyopathy (author's transl)].

Doxorubicin is one of the most effective antineoplastic drugs in clinical practice. Its clinical usefulness extends from acute leucemia and lymphoma to a wide range of solid tumors. However, the use of this drug is limited by its cardiac toxicity, that is often life-threatening. A number of clinical approaches discussed in this paper have been used to circumvent the problem of doxorubicin-induced congestive heart failure. A summarizing survey of the literature has led to establish two principles for prevention of doxorubicin-induced congestive heart failure with clinical meaning in the moment: --the way of administration --the clinical use of Ca-antagonist. The two principles provide an objective basis for preventation of congestive heart failure. The pathobiochemical background, analysed in this paper in detail, demonstrates that the same metabolic condition exist in the myocardial cell as in red blood cell. These interactions are the basis for a further analysis of metabolism in the cell, especially the redox metabolism of glutathione.

Animals↗
PubMed1981

[Alcohol and hematopoiesis].

In a survey of quantitative and qualitative changes of blood and blood-forming cell systems by big consumption of alcohol is informed about the frequency of such lesions and the importance of additional substances of alcohol, particularly of the fusel oils with their cancerogenic, mutagenic, hepato- and haemototoxic effects. The alcohol-conditioned lesions of the erythrocytopoiesis with disturbances of maturation by deficiency of folic acid under formation of a megaloblastosis, the alcoholinduced disturbances of the iron metabolism with increase of the sideroblasts as well as the formation of vacuoles in the cytoplasm of the proerythroblasts are discussed. In this connection the symptomatic anaemias, caused by alcoholic liver lesion and its sequelae as well as by ulcerous haemorrhage, particularly also of Zieve's syndrome, are discussed. Functional disturbances of the granulocytes and granulocytopenias are to be brought into connection with the particular susceptibility to infections of patients suffering from alcoholism. Functional disturbances of the thrombocytes and thrombocytopenias, to be sure, rarely lead to a haemorrhagic diathesis, deserve, however, more consideration as possible causing factors in apoplexias under big consumption of alcohol. On principle the direct alcohol-toxic (at least ethanol-toxic) defects of haemotopoiesis are reversible for a short time.

Alcoholism↗