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Biomedical subjects

H Schmidt

Publications and source records attributed to H Schmidt.

At least 1,135 records · Page 63Linked to original sources

The situation in Scandinavia.

The history of legislation controlling the treatment of venereal infections and undergraduate and postgraduate training in venereology is outlined. Arrangements for research into these infections and the advantages of centralized facilities for serum antibody tests are described. Syphilis, gonorrhoea, chancroid, and lymphogranuloma venereum are notifiable. One present problem is the difficulty of collecting information on non-gonococcal urethritis. There is a high incidence of infection in Greenland and further research should be undertaken there.

Denmark↗

[Diagnostic relevance of provocative (evocative) blood enzyme tests in pancreatic disease (author's transl)].

After a review of the literature the author's results of testing pancreatic function in 445 patients with different diseases are reported. The activities of serum amylase and lipase were estimated before and after stimulation with secretin and pancreozymin; at the same time exocrine secretions of the pancreas were collected in the duodenum and analyzed. Serum enzyme activity did not change markedly after stimulation in pronounced pancreatic insufficiency. Measuring the enzyme activity thus helped to make the diagnosis only in a few cases with chronic pancreatitis and pancreatic carcinoma. In all other patients there was no correlation between changes of serum enzyme activities and changes of exocrine pancreatic function. Pathological test results, that means an increase in enzyme activity after stimulation, were found not only in patients with established or suspected pancreatic diseases, but also in many other subjects. Thus the diagnostic relevance of these tests seems to be rather limited, since it does not prove or exclude with sufficient specificity or adequate probability the presence of pancreatic diseases; it therefore cannot be recommended for screening purposes.

Amylases↗

[Ectopic pregnancy near term (case-report) (author's transl)].

Description of a case of ectopic pregnancy during the last 3 months with a living, malformed and underdeveloped neonate. Possible treatment is discussed: where as in our case there is a secondary ectopic pregnancy (i.e.a pregnancy started primarily in the tube and still in vascular contact with it but secondarily ectopic) removal of placenta following ligation of the main vessels arising from the tube is possible and recommended. In the much rarer primary ectopic pregnancy with primary nidus in the abdomen, removal of the placenta is dangerous and not advised because of the danger of diffuse hemorrhage.

Cesarean Section↗

[Not Available].

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Dentistry↗

[The laryngeal cyst of the new born (author's transl)].

Only 30 cases of cysts of the ventricular cord in the new born baby have been published. Because of the respiratory stridor one third of the cases died soon or later. The other 2/3 were treated by endolaryngeal procedures. With a case of a new born suffering from a large cyst of the ventricular cord the author demonstrates the possible danger and inefficiency of different endolaryngeal procedures. Only the external operation through the thyrohyoid membrane with complete removal of the cyst - without tracheotomy--resulted in permanent cure.

Cysts↗

[Pulmonary artery pressure and left ventricular late diastolic pressure in rest and during dynamic load. Comparative studies on pressure transmission in the pulmonary circulation during simultaneous determination].

Left ventricular enddiastolic pressure (LVEDP), mean pulmonary artery pressure (PAPM) and enddiastolic pulmonary artery pressure (PADP) were simultaneously recorded in 19 subjects with normal left ventricular (LV) function, and in 109 patients with LV-dysfunction, 83 of whom were also studied during exercise. Patients with valvular heart disease or atrial fibrillation were excluded from this study. LVEDP and mean pulmonary capillary wedge (PCW) pressure were simultaneously recorded in 81 patients at rest, andin 16 patients also during exercise; the LV diastolic pressure prior to atrial contraction (LVPpreA) could accurately be identified in 45 patients at rest and in 23 patients with exercise. In contrast to the widely accepted opinion of others, the PADP (mean 8.2 +/- 2.2 mm Hg at rest and 12.3 +/- 3.4 mm Hg with exercise) showed a close approximation of LVEDP (10.0 +/- mm Hg at rest and 16.2 +/- 3.5 mm Hg with exercise) only in normal subjects at rest (p less than 0.05 and p less than 0.01 respectively). In patients with LV dysfunction there was no significant difference between PADP (11.7 +/- 4.5 mm Hg and 23.0 +/- 8.9 mm Hg), PCW (11.6 +/- 5.1 mm Hg and 24.1 +/- 11.9 mm Hg) and LVPpreA (12.5 +/- 5.5 and 21.5 +/- 7.7 mm Hg) at rest and during exercise. LVEDP could be estimated with sufficient accuracy only from the PAPM (18.9 +/- 6.5 and 35.7 +/- 10.8 mm Hg). The increase in LVEDP (14.7 +/- 7.7 mm Hg) with exercise was not significantly different from the increase in PAPM (16.8 +/- 7.1 mm Hg). There were highly significant correlations (p less than 0.001) between LVEDP and PADP (r = 0.85) as well as PAPM (r = 0.86) at rest and during exercise with the regressionline being closest to the line of identity for LVEDP and PAPM. The pressure gradient between LVEDP and PADP (LVEDP - PADP = 6.3 mm Hg with exercise) equaled the pressure increase in LV by atrial contraction (LVEDP - LVPpreA = 6.3 and 13.3 mm Hg). The pressure difference between PADP or PAPM and LVEDP remained constant despite marked variation of other hemodynamic parameters, e.g. stroke volume index (SVI), heart rate (HR) and cardiac index(CI). These data suggest that an elevated LVEDP is caused mainly by an augmented atrial contraction in patients with LV dysfunction at rest and with exercise. This mechanism precludes an enddiastolic pressure equilibrium between pulmonary artery and left ventricel. PAPM allows the best estimation of LVEDP independent from other hemodynamic variables.

Adult↗

[Investigations on the distribution, cause and prevention of early perinatal morbidity (author's transl)].

These investigations were designed to detect causes of early perinatal morbidity in order to develop methods to decrease the perinatal morbidity in our unit. From October 1972 to December 1974 the most important antenatal, intrapartum and postpartum data on 2210 deliveries were coded. In 98% of the cases continuous fetal monitoring was performed. To detect early perinatal morbidity the acid base balance of all deliveries was measured from the umbilical vessels and the Apgar rating was determined at 1,5 and 10 minutes. The data show that a further decrease of the incidence of acidosis and low apgar scores is only possible in a limited way. Of the 13% deliveries with pH values of/or less than 7.15 or Apgar scores of/or less than 6 at 1 minute, only 5% appeared to be avoidable in this retrospective study. The incidence of severe acidosis decreased from 2.3% in 1972 to 1.3% in 1974. A comparison of the years 1973 and 1974 showed an improvement. Apgar scores of 6 or less at one minute decreased from 16 to 10% and severe acidosis with pH values of less than 7.10 decreased from 2.7% to 1.8%. In vaginal operative deliveries, the incidence of severe acidosis was reduced from 8.5% to 1.1%.

Acidosis↗

[Combined appearance of an intracranial and spinal meningioma in a case of Recklinghausen's disease].

In a young man with Recklinghausen's disease a large dextral wing-of-sphenoid meningioma and a spinal meningioma were extirpated at an interval of one month. A couple of months later further interventions were necessary because of a bilateral acoustic neurinoma. The patient's mother had multiple intracranial meningiomas and also a bilateral acoustic neurinoma. The medical history of the patient is reported. Also discussed are problems associated with the diagnosis of the spinal meningioma.

Adult↗

[Medulloblastoma and pineoblastoma in monozygous twins (author's transl)].

Clinical and neuropathological findings in monozygous twin sisters are reported. Twin I died at age 5 months from a cerebellar medulloblastoma, whereas her sister died at age 16 months from a pineoblastoma. The tumors are considered similar referring to histogenesis, structural peculiarities and growth. Therefore, the twins are seen as concordant for the tumor type.

Autopsy↗