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Biomedical subjects

H Saraux

Publications and source records attributed to H Saraux.

At least 55 records · Page 3Linked to original sources
PubMed1987

Quantitative autoradiographic determination of binding sites for a peripheral benzodiazepine ligand ([3H]PK 11195) in human iris.

Specific binding sites of peripheral-type benzodiazepines were investigated in human iris/ciliary body (8 eyes). Examination of color-coded prints and densitometric quantification of autoradiograms were performed on slides (20 micron) labelled with [3H]PK 11195 (1 nM) at 25 degrees C. Nonspecific binding was determined with PK 11211 (5 microM) or Ro 5-4864 (5 microM). Binding sites were present on all the slides, with equivalent density in the 3 regions of the preparation (ciliary body, iris, and pupil margin). The numbers of binding sites in ciliary body, iris, and pupil margin, respectively, were: 42.7 +/- 0.2, 30.1 +/- 0.5, and 37.4 +/- 0.4 femtomol/mg protein. Labelling on the pupil margin seemed to coincide with the iris sphincter muscle. The presence of peripheral benzodiazepine binding sites in iris muscular tissue, and particularly in the pupil margin, suggests that the iris preparation may be a valuable tool to detect putative physiological effects of peripheral benzodiazepines on muscular motility.

Aged↗
PubMed1987

Management of retinal detachment without tear by topical therapy (atropine and timolol).

14 various kinds of retinal detachments were treated by timolol + atropine eye drops. 4 cases were primary procedures and required no further surgery. 10 cases were recurrent detachments after episcleral or endo-vitreous surgery. In 8 cases there was a notable proliferative vitro-retinopathy. 10 cases were completely flattened by this medication and we obtained the reapplication of the posterior pole and the upper retina in the 4 other cases.

Administration, Topical↗
PubMed1987

Acute posterior multifocal placoid pigment epitheliopathy. A long-term follow-up.

Acute posterior multifocal placoid pigment epitheliopathy is now perfectly documented on clinical and angiographic findings. Gass has emphasized the good prognosis and the infrequency of recurrence. Some cases have, however, multiple recurrences and loss of sight. It seems of interest to discuss the long-term prognosis of acute posterior multifocal placoid pigment epitheliopathy.

Adult↗
PubMed1987

Contrast sensitivity in multiple sclerosis. A study in 35 patients with and without optic neuritis.

Binocular and monocular contrast sensitivity (CS) functions were determined for 35 patients with multiple sclerosis (MS) of whom only 21 had a history of optic neuritis. CS was abnormal in all 21 of these patients; alterations of CS affected all spatial frequencies, not only for the eye with optic neuritis, but also for the clinically unaffected eye (p less than 0.01). Approximately one third of the 14 patients with MS but without any history of past visual disturbances showed an optic nerve involvement. Our results show that (1) clinically visual impairment is bilateral, even if optic neuritis seems unilateral, and (2) CS can detect silent lesions of the visual pathways in MS and may prove to be more sensitive than visual evoked potentials.

Adult↗
PubMed1987

[Trabeculectomy. Long-term retrospective study].

Long term follow up of 51 eyes treated by trabeculectomy between 1975 and 1978. The pressure remains below 20 mmHg in 94% of our cases and progression field loss is stopped in 60%. The control of pressure needs adjunction of a medical treatment in 47% of cases. Progression of glaucomatous field loss is stopped when the ocular pressure is very low (40% or more of initial pressure). Cataract is seen in oldest patients. These observations suggest that: glaucoma surgery must give a sufficient drop of ocular pressure in all cases with pressure between 15 and 20 adjuvant medical therapy is useful old patients are a poor material for glaucoma surgery.

Age Factors↗
PubMed1986

[Multifocal inner choroiditis: pseudohistoplasmosis. The European form of the presumed American histoplasmosis].

We studied nine patients with the picture of presumed ocular histoplasmosis. All patients had the characteristic triad: punched out peripheral lesions, peripapillary atrophic scar and disciform process in the posterior pole. All patients had negative test for histoplasmosis (electrosyneresis). Four patients were observed for a long period (8, 8, 7 and 4 years). In two cases we could observe the first step of the basic choroidal lesions. One of these patients fundus was previously normal. Age, female to male ratio and in one case mild inflammatory lesions were similar to a new entity: multifocal choroiditis. The cause of European disseminated inner choroiditis remains unknown. There may be one or multiple causative agents including unidentified fungus.

Adolescent↗
PubMed1985

[Retinal vasculitis in lupic disease].

Three cases of retinal vasculitis in SLE-type diseases are reported. The first was central retinal vein occlusion occurring during clinical remission of SLE in a 55 year old black female. Prednisone maintenance therapy was unchanged and visual loss rapidly regressed with heparin therapy. The second case was a 33 year old black female in whom SLE was discovered following relapsing bilateral optic neuritis. A progressive visual improvement was obtained with high dose of prednisone (1 mg/kg/day). The third cas was a 17 year old white girl with retinal vasculitis. She had an unclassified connective tissue disease inaugurated by optic neuritis at the age of 10. High dose prednisone (1 mg/kg/day) was effective on the visual loss. Retinal vasculitis lesions in SLE and their therapy are reviewed.

Adult↗
PubMed1985

Secondary Fuchs's heterochromic cyclitis: a new approach to an old disease.

A study of 17 cases of Fuchs's heterochromia. Among these patients 10 had chorioretinal scar. In 3 cases the disease was seen after chronic cyclitis in a case after traumatism. Fuchs's heterochromia seems be in almost all cases a secondary disease. We do not know how a primary ocular disease can lead to Fuchs's syndrome. it is possible that this mechanism is autoimmune.

Adolescent↗
PubMed1985

[Exudative retinopathy with dominant transmission. Report of a new pedigree].

A family with the syndrome of familial exudative vitreoretinopathy is described. A 7-year-old presented a non-perfused, avascular periphery in the temporal retina. The father is blind and his fundus was described in childhood as showing vitreoretinal traction, retinal telangectasia and temporal fibrotic changes. A cousin of our patient, a 5-year-old girl, was seen with vitreoretinal traction of the posterior pole. Familial exudative vitreoretinopathy is sometimes confused with retrolental fibroplasia. The family history and a fluorescein angiographic study of non-affected members are useful for confirmation of this diagnosis: pathophysiologic mechanisms and optimal treatment of the disease still remain about discussion.

Adult↗