Search PubMed⌕ Search

Biomedical subjects

H Saraux

Publications and source records attributed to H Saraux.

At least 37 records · Page 2Linked to original sources
PubMed1990

Beta adrenergic binding sites in the human eye: an autoradiographic study.

Beta adrenergic binding sites were localized and characterized in the human eye by means of "in vitro" autoradiography, using [125I] (-) iodocyanopindolol (125ICYP) as radioligand. Binding sites were visualized by apposition of isotope sensitive film to slide mounted eye sections. Receptor sites were present in the extraocular muscles, in the conjunctiva, in the epithelium and endothelium of the cornea, in the trabeculum and in the ciliary muscle. They were also present in the lens epithelium and in the retina. The pigmented ocular structures were heavily labelled but the binding was nonspecific. Characterization of these binding sites was achieved by testing the ability of selective adrenergic compounds to displace 125ICYP binding. These studies suggested that the majority of adrenergic binding sites in nonpigmented structures of human eye were of a beta2 type.

Aged↗
PubMed1990

[Evaluation of the efficacy of plasma exchange in Leber's disease].

Amaurosis congenita of Leber is a hereditary optic neuropathy, usually bilateral, that quickly leads to blindness. There is no effective treatment. The inflammatory aspect of the papillary lesions in the early stage, in addition to the beneficial effect of plasma exchanges reported for other optic neuritides, led us to propose such a therapeutic regimen to 6 young adult men afflicted with the disease. This treatment was initiated early, before optic nerve atrophy occurred. The plasma volume exchanged was 3.2 +/- 0.5 liters/session and 4.2 +/- 1.8 (3 to 7) exchanges were performed. The exchanges were always well tolerated. Three patients subjectively reported improvement immediately following the exchanges but only one had some improvement of his visual acuity. However, a more sensitive evaluation of the ability to distinguish contrasts revealed improvement in patients whose visual acuity remained unchanged. This visual gain was lost 3 months later. Therefore, it appears that plasma exchanges are not the treatment of choice for this disease.

Adult↗
PubMed1990

[Contrast sensitivity and diabetes].

Contrast sensitivity has been assessed in 24 diabetic patients in order to test the hypothesis that contrast sensitivity is impaired in the early stages of diabetes mellitus. All patients had 20/20 vision. Some evidence of visual dysfunction was observed in 33% of the diabetics with no retinopathy and 83% of the 6 patients with retinopathy when compared to 48 age-matched controls. Contrast sensitivity was mainly reduced in the mid-range spatial frequencies and correlated with the degree of retinopathy. The accurate assessment of visual dysfunction in diabetes is very important, as new drugs (i.e. aldose reductase inhibitors) are currently under evaluation.

Contrast Sensitivity↗
PubMed1990

[Value of a study of contrast sensitivity in the evaluation of visual function: applications to pathology and visual selection].

Spatial contrast sensitivity function appears to give the most general description available for the basic aspect of spatial visual performance. Classical measurement of visual acuity is unable to give us a fine appreciation of visual function. Visual acuity is only one aspect of the complex process of sight. We have tested contrast sensitivity to detect silent lesions of the visual pathway. In multiple sclerosis we have demonstrated a bilateral involvement in almost all cases. In primary open angle glaucoma contrast sensitivity is affected before perimetry data are able to show any defect. We have the same results in early stages of diabetic retinopathy. Contrast sensitivity testing shows great promise for detection of eye defect in drivers and industry workmen.

Contrast Sensitivity↗
PubMed1990

[Ophthalmologic manifestations of the Pierre Robin syndrome. Report of a case of microphthalmia].

The classical description of the Pierre Robin syndrome includes micrognathia, glossoptosis, airway obstruction, and usual presence of a cleft palate. The Pierre Robin syndrome is currently defined as the combination of retrognathia, cleft palate, and respiratory distress. This last is mixed, with a peripheral component due to glossoptosis and a central component due to brain stem immaturity. The main ocular manifestations found in the Pierre Robin syndrome are congenital glaucoma and severe congenital mypopia responsible for retinal detachment. Microphthalmia is infrequent. We report the case of a neonate with severe Pierre Robin syndrome and major microphthalmia documented by CT scan.

Female↗
PubMed1989

[Vitreous hemorrhage and neovascular proliferation in multiple sclerosis].

We report the case of a 40 year-old man with multiple sclerosis, who presented a bilateral proliferative retinopathy responsible for a vitreous hemorrhage. Examination of the periphery of the retina showed diffuse retinal periphlebitis; fluorescein angiograms showed a peripheral retinal ischemic syndrome with secondary neovascularization. Several recent studies have show that retinal periphlebitis is a frequent finding in multiple sclerosis; but to our knowledge a retinal ischemic syndrome with neovascularization has seldom been reported.

Adult↗
PubMed1989

[Long-term follow-up and etiologic factors in edematous forms of central retinal vein obstruction].

We report a study of 61 cases of retinal vein occlusion, followed for 3-10 years. The oedematous form only were studied; 39 were branch vein occlusion (BVO) and 22 central retinal vein occlusion (CRVO). Of the CRVO's 5 were female, 17 were male, ages ranged from 5 to 75 years, averaging 58 years of the BVO's there were 19 females and 20 males with ages ranging from 27 to 79 years, averaging 61 years. High blood pressure and atherosclerosis were the most frequent causes. High intraocular pressures were mostly associated with CRVO (25%). Study of serum lipids and blood coagulation are most useful in CRVO in young patients. Platelet agreggation anomalies, protein C deficiency were seen in some cases. Visual prognosis is relatively good; bilateralisation was seen in 5% of BVO and in 9% of CRVO. Visual acuity better than 20/200 was observed in 87% of BVO and in 75% of CRVO.

Adult↗
PubMed1989

[Contrast sensitivity is not only an additional complementary test].

Contrast sensitivity gives new insight on visual troubles encountered in ophthalmology. Indeed the measurement of this function yields some explanations on how vision is impaired by diseases frequently observed by clinicians. The deficits seen in strabismic amblyopes raise the possibility that the neural impairment in amblyopia is derived from a single continuum, varying in degree. The absence of stimulation of the size-selective detectors processing high spatial frequencies accounts for the shape of the contrast sensitivity curve in congenital nystagmus. Glaucomatous or multiple sclerosis patients show early deficits in medium range spatial frequencies where the sensitivity is the highest. These changes appear sometimes before any other investigation can detect them. When compared with physiological results using the same sinusoidal gradings as stimuli, contrast sensitivity gives reliable informations on how visual information is processed by the brain.

Amblyopia↗
PubMed1989

[Homonymous lateral quadranopsia disclosing cerebral toxoplasmosis in a patient with AIDS].

A case of Homonymous lateral quadranopsia revealing cerebral toxoplasmosis is reported in AIDS patient. Neuro-ophthalmologic manifestations must be explored by neuro-radiologic examination. Nuclear magnetic resonance would rather be performed than CT scan. Frequencies of cerebral and ocular toxoplasmosis localisations are compared. Severity of toxoplasmosis localisation justifies an early diagnosis based on immunological assay detecting the infection. Prophylactic treatment has to be instored.

Acquired Immunodeficiency Syndrome↗
PubMed1989

[Microphthalmos in Pierre Robin syndrome. Clinical and x-ray computed tomographic study].

The Pierre Robin Syndrome is characterized by three defects (8,9): micrognathia, cleft palate and glossoptosis responsible for respiratory failure. The new definition of this syndrome associates retrognathia, cleft palate and respiratory distress. This respiratory distress is mixed: obstructive due to glossoptosis, and central, secondary to brainstem immaturity (1,2). The main ocular manifestations associated with the syndrome are congenital glaucoma, high congenital myopia and retinal detachment. Microphtalmia has already been reported, but is infrequent. We present a clinical case of a major microphthalmia in a Pierre Robin Syndrome, confirmed by CT scan exploration.

Eye Diseases↗
PubMed1988

[Natural history of malignant melanoma of the choroid].

Study of five patients with uveal melanomas, followed 3 to 11 years without treatment. In all cases the tumor progressed, involving orbital tissue in 2 cases. One patient died of metastasis after 4 years of evolution. The authors emphasize the variability of the growth rate in individual cases which explains the various clinical aspects. Metastasis can be seen in treated or untreated melanomas, often after a prolonged period. In case four, pulmonary metastasis was documented 20 years after enucleation with a very low growth rate. Natural history of uveal melanoma shows a low but regular growth which ends in local and general extension.

Aged↗
PubMed1988

[Surgical orbital decompression in Basedowian optic neuropathy. Apropos of 5 cases].

Surgical orbital decompression in 5 patients with basedowian optic neuropathy restored the visual acuity and visual field in all cases. The place of surgery among the different therapeutic options proposed for this serious complication of Basedow's disease is discussed, as well as the advantages over other decompression techniques of the procedure used : the cutaneous approach to a trans-ethmoidonasal decompression.

Adrenal Cortex Hormones↗
PubMed1988

[Treatment of blepharospasm and facial hemispasm by injection of botulinum toxin].

13 patients with hemifacial spasm and 19 patients with blepharospasm (essential blepharospasm or Meige syndrome) were treated with injection of botulinum A toxin in the eyelids. The effectiveness of this therapy is constant and the treatment offers relief to almost all patients. The response times for repeated treatment was 6 months for blepharospasm and 7 months for hemifacial spasm. Repeated injections were performed in several patients and gave the same improvement. Transient ptosis or diplopia were observed in 11 patients. Possible systemic side effects (respiratory trouble) were documented in two patients. Botulinum toxin injection is an effective treatment but the relief is usually temporary and repeated treatments are necessary.

Adult↗
PubMed1987

Binding sites for a peripheral type benzodiazepine antagonist ([3H]PK 11195) in human iris.

Peripheral-type benzodiazepine binding sites have been characterized on sections of 8 normal human iris/ciliary-body preparations. Saturability was determined at 25 degrees C with [3H] PK 11195 (1 nM) a specific ligand of peripheral type sites. The studies revealed a single class of binding sites for PK 11195 with a nanomolar range affinity (KD = 1.45 nM) and a maximal capacity (Bmax) of 35.5 fmol/mg protein. The displacement potency order of the benzodiazepines tested suggest that these sites belong to the peripheral type: PK 11211 (IC50 = 12 nM) greater than Ro 5-4864 (IC50 = 770 nM) greater than clonazepam (IC50 = 20,000 nM). The present data demonstrate that high affinity binding sites for peripheral type benzodiazepines are present in human iris/ciliary-body. This tissue is therefore a suitable tool for evaluation of the putative functional role of these binding sites.

Aged↗