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Biomedical subjects

H Salzer

Publications and source records attributed to H Salzer.

At least 163 records · Page 9Linked to original sources
PubMed1977

[On the optimal clarification of suspicous findings on the cervix uteri (author's transl)].

In the period 1972--1975 432 conizations were performed. 76,6% of all patients were dismissed healed after conization without necessity of hysterectomy; the duration of stay in hospital after operation was in uncomplicated cases 7,9 days, in complicated cases 9,9 days. In 13,9% complications were registered, mainly bleedings (10,9%). In more than half of the cases with not totaly removed carcinoma in situ the uterus showed rests of the malignant lesion. That indicates that in such situations a hysterectomy should be done in every case. If there was a suspicion of invasive carcinoma an excochleation was performed instead of cone biopsy. The high rate of false negative results in such cases confirms that the conization at the moment seems to be the method of choice in clarification of positive cytologic or colposcopic findings.

Adolescent↗
PubMed1977

[Surface tension properties of the amniotic fluid obtained by serial puncture in normal pregnancies (author's transl)].

Serial amniotic fluid samples were obtained in the last trimester of pregnancy during the course of 12 uneventful pregnancies. The surface tension properties of the amniotic fluid samples were measured in the surface (Wilhelmy) balance. Eight pregnancies showed a normal pattern of surface activity parameters, whereas in four pregnancies the pattern was abnormal. The pattern of surface activity parameters is shown individually for each of the 12 pregnancies and the possible reasons for individual variations are discussed.

Amniocentesis↗
PubMed1976

[The importance of the risk factor "obesity" during gravidy (author's transl)].

Between 1. 6. 1972 and 31. 12. 1974 obese gravidae with a body weight of 90 kg or more were observed (7,6% of all patients in this period). This 315 patients were compared with a group of 315 patients with normal body weight chosen by random. The results of both groups were compared and evaluated by statistic (t-test, x2-test). A significant higher rate of Diabetes, latent Diabetes, EPH-Gestosis and cases of over-term deliveries were found in the group of obese patients.

Age Factors↗
PubMed1976

[The importance of the risk factor "obesity" during delivery, postpartal and for the newborn (author's transl)].

The course of delivery and labor, the post partum period and the postpartal condition of the newborn were reviewed in 315 obese patients with a bodyweight of 90 kg or more at delivery. The results were compared with those of a group of 315 patients with a body-weight of less than 90 kg, choosed by random and evaluated by statistic (t-test, x2-test). In the group of obese gravidae we found a significant higher rate of cases with induction of labor, protracted deliveries, breech presentation and operative deliveries. Also the rate of manual removal of the placenta, post partum uterine infections and disorders in the milk secretion was significant higher in this group. Post partum abnormal glucose tolerance tests ocurred abnormal more frequently in the obese patients. The weight of the infants of obese mothers was higher as in the control group. Significant higher were the perinatal mortality and the cases of fetal death in utero in the obese group compared to the non obese group.

Apgar Score↗
PubMed1975

Ovulation inhibition with human chorionic gonadotrophin.

Eight women with regular menstrual cycles were treated daily during 9 cycles with HCG (Human Chorionic Gonadotrophin) 3000 or 5000 IU daily for a period of 4-7 days. This treatment was started between the 1st and the 6th day after the onset of menstruation. Control of the treatment cycles was performed by basal body temperature, pregnanediol serial estimations, endometrial biopsies and in addition in 5 treatment cycles by radio-immunological assay of estradiol-17 beta (Oe2), progesterone, LH and FSH from the serum at intervals of 1 to 3 days. In 6 of these cycles where treatment started on the 4th day or later, ovulation was inhibited (2 cycles) or postponed (4 cycles) to the 24th-46th day. In these 6 treatment cycles the progesterone and pregnanediol increase during HCG treatment was poor or absent. The typical Oe2 increase of the normal menstrual cycle was impaired. In the 3 remaining cycles where treatment was started on the 1st, 2nd and 4th day, we observed during HCG treatment increases in Oe2 and progesterone serum values similar to that found during corpus luteum activity, and menstruation from a secretory endometrium between the 13th-19th day of the cycle. The histologically examined ovaries of one woman who was treated with HCG from the 2nd to the 6th day of the cycle showed distinct luteinization of the theca interna of all tertiary follicles and a beginning degeneration of the granulosa. These findings give support to the hypothesis that the luteinization of the theca interna leads to degeneration of the tertiary follicles thereby causing ovulation inhibition or postponent of ovulation.

Adult↗
PubMed1975

Progesterone, oestradiol-17 beta and testosterone levels in the follicular fluid of tertiary follicles and Graafian follicles of human ovaries.

Radioimmunoassays of testosterone (T), oestradiol-17 beta (Oe2) and progesterone (P) in the fluid of a total of 47 follicles of different degrees of maturity gave the following mean values: T: 49 ng/ml, Oe2: 932 ng/ml, P: 999 ng/ml. In normal, atretic and cystic tertiary follicles not larger than 1 cm and without luteinized theca interna the following mean values were calculated: T: 54 ng/ml, Oe2: 502 ng/ml, P: 368 ng/ml. In six women mature and less mature follicles were compared, the former having significantly higher Oe2 and higher P values but significantly lower T values than the latter. Genuine Graafian follicles were observed four times, once after HMG stimulation; the values observed lay within the following ranges: T: 12-35 ng/ml, Oe2: 1900-4100 ng/ml, P: 156-6000 ng/ml. The difference in concentration compared with cubital-vein blood before ovulation was highest for Oe2, suggesting a particularly marked aromatinzing activity of the follicles of that phase of the cycle. The findings suggest that in the course of accelerated follicular ripening prior to ovulation both the aromatizing enzyme and 3 beta-hydroxysteroid-dehydrogenase are activated, resulting in a sharper rise in Oe2 and P. The profuse production of P causes a transistory lack of precursors for androgen and oestrogen production (T and Oe2 declines). In the course of an overall increase in steroid production during the luteal phase - which probably goes hand in hand with an increased supply of pregnenolone - there is not only a pronounced rise in progesterone but also a moderate increase in oestrogen production. The androgens are transformed more rapidly into oestrogens on account of the marked activity of the aromatizing enzyme in the corpus luteum and thus show a decline in the luteal phase.

Adult↗
PubMed1975

[Phospholipids under combined ozone-oxygen administration].

The parenterally application of oxygen-ozone gas mixture gives good resultats in the treatment of various deseases. Ozone seems to influence the metabolic process of fat, so it was of interest to analyse this influence especially to phospholipids. 40 women with gynaecological cancer got 10 ml oxygen-ozone gas mixture with a content of 450 gamma ozone into the cubital vene. Venous blood was removed before and 10 minutes after application and the level of lecithin, lysolecithin, cephalin and spingomyelin was determined by the method of Randerath. A decrease of all four substances was obvious, although all values remained in normal range.

Female↗
PubMed1975

[Pollen diet as an adjuvans of radiotherapy in gynecologic carcinomas].

The introduction of a pollen diet as an adjuvant in the reduction of side effects during radiotherapy of patients with gynaecological cancer is described and its efficacy evaluated. 15 women with carcinoma of the cervix received a pollen diet during irradiation, whilst ten further patients receiving irradiation served as controls without pollen added to the diet. Serum enzymes, proteins, vitamins and blood count were analysed before and after irradiation. It appears, that pollen favourably influences the efficacy of irradiation and reduces the frequency of side effects, both subjectively and objectively.

Alanine Transaminase↗
PubMed1975

[Sarcoma uteri and neurofibrosarcoma in a case of Recklinghausen's disease].

A case of Neurofibromatosis Recklinghausen with Sarcoma uteri is reported. After 23 years absence of recidivity a plum-sized, hard tumor was diagnosed in the left inguinal region. Primarily this tumor was thought to be a late relapse of sarcoma uteri, but in fact it was a neurofibrosarcoma. The connections between sarcoma uteri and neurofibrosarcoma is discussed, because a new histological examination could detect neurofibromal cells in the uterine tumor.

Aged↗
PubMed1971

Insect stings.

Explore the source record for details and available documents.

Administration, Oral↗
PubMedDate not supplied

[Dynamic measurement of surface tension versus gas chromatography dipalmitoylphosphatidylcholine analysis of amniotic fluid; a comparison of a bedside method with a highly specialized surfactant analysis].

The diagnosis of fetal lung maturity by analysis of the amniotic fluid still constitutes a present-day problem. In this study the results of measuring the dynamic surface tension by the Wilhelmy-balance were compared with the DPPC (Dipalmitoyl-Phosphatidyl-Choline) and lecithin species-analysis by the quantitative capillary gas chromatography. The first possibility is a "bed-side"-method, which evaluates the effect of the surfactant in the amniotic fluid in its entirety, whereas the second method represents a highly specialized laboratory procedure analysing the most important part of surfactant contact. The surface tension of amniotic fluid is expressed by its value at 20% of the extension of the surface (gamma-min) as well as the hysteresis area. We were able to show a better correlation between the hysteresis area and the DPPC (r = 0.422, p less than 0.012) than between the gamma min and the DPPC (r = 0.370, p less than 0.031). The correlation between the hysteresis area respectively between the gamma-min, and the second gas chromatographically detectable component of the surfactant, PC 30 was not so distinct (r = 0.068, p less than 0.744; R = -0.355, p less than 0.075). Obviously this component of the surfactant is not as active on the surface and therefore not as important. Further we could show, a negative correlation to the lecithin species PC 34; with increasing surface activity and increasing lung maturity this lecithin species quantitatively recedes into the background.

1,2-Dipalmitoylphosphatidylcholine↗
PubMedDate not supplied

[Carnitine in therapy of placental insufficiency--initial experiences].

Carnitine (3-hydroxy and 4-trimethylaminobutyrate) present in all living cells, plays an important role in the oxidation of fatty acids. It is known that high dose carnitine activates surfactant synthesis. Given to women with imminent premature delivery, its benefit on the post natal period is proved. Own studies showed an increased need of carnitine during pregnancy. Therefore the questions rose if carnitine substitution improves placental insufficiency. 15 pregnant women were treated with 2 x 1 g carnitine orally for one week and with 1 x 1 g carnitine during the following 7 days when their fetus showed a retardation of 1-3 weeks. The control group were 15 untreated patients with the same problems of retardation. The placental insufficiency was diagnosed by fetometry, by blood parameters and the doppler ultrasound flow measurement. In the group of the treated patients 11 out of 15 showed an improvement, in 4 patients no effect of carnitine was seen and in 1 patient the retardation increased. In the control group 8 out of 15 patients showed a spontaneous improvement of fetal growth, 2 women did not have a change in their retardation and 5 patients had to be hospitalized because of increasing placental insufficiency. Inspite of the small number of patients a tendency towards a profit in carnitine treatment for placental insufficiency seems to be real.

Birth Weight↗
PubMedDate not supplied

[Carnitine levels in pregnancy].

Carnitine (trimethylamino-hydroxy butyric acid) is present in all living cells. It is necessary for the transport of fatty acids into mitochondria and for other metabolic functions of the cell. Studies in various animal species have demonstrated a transfer of carnitine from the mother to the fetus during pregnancy. Recent studies reported decreased carnitine levels at term, but little is known on carnitine levels during various stages of human gestation. Therefore it was interesting to measure the blood carnitine status during normal human pregnancy from early stages up to term, including analyses of umbilical cord blood of the newborn. The results show a gradually decreasing carnitine level in maternal plasma, a sharp decline within the 1st trimester was followed by a much slower but highly significant decrease in the 2nd and 3rd trimester. In whole blood carnitine levels are decreasing, too. The continuous decrease of the portion of plasma carnitine in whole blood is correlated with a higher carnitine concentration in the blood cells. Together these results might indicate an increased need of carnitine during pregnancy. Therefore the clinical application of carnitine not only to provide a respiratory distress syndrome should be examined.

Blood Cells↗