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Biomedical subjects

H Salzer

Publications and source records attributed to H Salzer.

At least 145 records · Page 8Linked to original sources
PubMed1980

[Surface properties of serum in case of premature onset of labour (author's transl)].

Fifty-eight pregnant women with premature onset of labour were compared to 149 women with normal course of pregnancy. Surface activity of the serum in the former group was found to be higher than that in the latter. The information obtained from determining the hysteresis curve of the serum by means of Wilhelmy's balance was much more complete than that recordable from surface tension with 20 per cent surface expansion (gamma minimum). An analysis was made, at the same time, of those serum parameters with highest surface activity, such as free fatty acids and lecithin. Their growth in concentration was found to coincide with onset of labour proper rather than with a condition in which the organism simply exhibited a trend towards premature labour. Hence, measurement of serum surface tension proved to be the more sensitive parameter by which to predict forthcoming premature labour. The actual cause underlying such behaviour so far has remained unelucidated, since an extremely sophisticated process has to be assumed to take place on the serum surface. These studies, consequently, have not been completed. They are likely, however, to provide some preliminary hints on quite peculiar serum changes in concomitance with premature labour or with the trend to it.

Fatty Acids, Nonesterified↗
PubMed1980

[Dynamic surface tension measurements and L/S-ratio in amniotic fluid before birth in comparison with the respiratory compliance of the newborns immediately after parturition (author's transl)].

In 65 pregnant women between 27th and 42nd gestational week amniotic fluid was collected on average of 4,2 hours before birth and its amount of surfactant determined by means of the dynamic surface tension measurement in the Wilhelmy-balance and the L/S-ratio. These values were compared to the respiratory compliance of the newborns after birth. The respiratory compliance was measured by means of the airway occlusion technique. So far the measurement of dynamic surface tension has made it possible to predict the lungmaturity and the incidence of RDS. Our study for the first time describes a quantitative relationship between the surface tension of the amniotic fluid and the surface tension of the lungs in form of the respiratory compliance. The surface tension, measured by the Wilhelmy-balance, was better correlated (r = -0.85) than the L/S-ration (r = 0,58) with the respiratory compliance of the newborns. The surface tension measurement allows therefore a better prediction of the severity of the RDS than the determination of the L/S-ratio. This can be explained by the fact that the surface tension measurement in the amniotic fluid represents the total effect of SAM (Surface active material) while the L/S-ratio represents only about 60% of SAM. On the other hand the L/S-ratio gave a better correlation to the general maturity of the fetus than the surface tension; therefore we consider that the L/S-ratio is partially influenced by the lungmaturity and partially by gestational age of the fetus.

Amniotic Fluid↗
PubMed1980

[Courses of pregnancy and deliveries of 107 women with longstanding desire for children. Comparison with normal group (author's transl)].

The records of a selected group of 107 women who became pregnant and delivered, after having been attended to for sterility at the First Obstetric and Gynaecological Department of the Viennese University Hospital, were reviewed and compared to data of a control group which had been selected at random. Mild gestosis was more often recorded from patients who had been treated for sterility (47 per cent), whereas moderate or severe gestosis was more often recorded from the controls. Tocolytic agents were orally administered to 30 per cent of those women who had been treated for sterility. Duration of labour was longer and dystocia more frequent in the sterility treatment group. The percentual rates of surgical delivery and caesarean section were about the same in both groups. SGA was recorded from 30 children of the first but only eleven children in the control group. The average birth weight of babies born to mothers, following treatment for sterility, was 120 g lower than that in the control groups. Particular attention should be given to placental insufficiency in any pregnancy, following treatment for sterility. There was obviously no increased frequency of severe obstetric complications.

Adult↗
PubMed1979

[Ozone-oxygen therapy for gynecologic carcinomas. The effect of parenteral-ozone oxygen mixture administration on free fatty acids and triglycerides in patients with gynecologic carcinomas].

As some authors suspect that ozone influences the metabolic process of fat, we tried to analyse the influence of an ozone-oxygen gas which was applied parenterally. 40 patients with gynecological cancer received 10 ml ozone-oxygen gas with a content of 450 gamma ozone and venous blood was removed before and 10 minutes after application. The serum was lyophilized and the level of fatty acids and triglycerids was determined by the method of Randerath (1965). a statistically significant decrease of the concentrations was observed after application of ozone. Different theories as to the cause of this action are discussed.

Clinical Trials as Topic↗
PubMed1979

[Etiology of RDS in infants weighing more than 2500 g (author's transl)].

Between 1974 to 1977, 7005 infants were born live at the I. University Clinic of Obstetrics and Gynecology, Vienna. 55 of these infants weighed at birth more than 2500g and developed RDS (Respiratory Distress Syndrome) as a result of which 16 died. All infants showing either malformations, icterus gravis (malignant jaundice) or infants delivered by insulin dependent diabetic mothers were excluded. The remaining 48 infants were compared with two control groups selected at random. The mortality rate for infants with RDS weighing more than 2500g (29,1%) was identical with those weighing less than 2500g (28,7%). The significant finding in the RDS group was the high incidence of primiparae, mothers with abnormal obstetrical histories, imminent abortion, cerclage operations and EPH gestoses. On three women in this group extragenital surgery which was performed during pregnancy appeared noteworthy. Time of labor, prolonged delivery time or surgical interference at time of birth did however not seem to make any difference. The RDS group showed in the 1 minute as well as in the 5 minute Apgar-Value distinctly worse results, whereby the missing recuperation after 5 minutes is typical and prognostically unfavourable for RDS. Of decisive importance for the development of RDS in infants weighing more than 2500g was birth induction before the end of the biological term.

Apgar Score↗
PubMed1978

[Hormone profiles and hormone therapy in early pregnancy (author's transl)].

Hormone profiles in early pregnancy were established in 67 women and correlated to simultaneously performed ultrasonic examinations. Normal values for human chorionic gonadotropin (HCG), human chorionic somatotropin (HCS), oestradiol (E2) and progesterone (P) were established from the data obtained in 30 early pregnancies which culminated in the birth of a living child. Lowered HCG values were found in 17 out of 23 pregnancies which ended in miscarriage. In these cases ultrasonic examination failed to detect any heart action. Lowered HCS values after the 9th week of pregnancy are also certain proof of missed abortion. P and E2 values are shown to be a parameter reflecting activity of the corpus luteum graviditatis. In clomiphene- and gonadotropin-induced pregnancies higher values were found than in pregnancies managed by substitution treatment with twice weekly 10 mg oestradiolvalerianate + 500mg 17alpha-hydroxyprogesteronecapronate. Lowered P and E2 values with HCG values in the normal range indicate imminent insufficiency of the corpus luteum graviditatis. Pros and cons of hormonal therapy in early pregnancy are discussed.

Abortion, Missed↗
PubMed1978

[Fetal lung maturity in differen abnormal pregnancies (author's transl)].

The influence of pathological situations to fetal lung maturation during the last 9 weeks of pregnancy was studied. Lung maturity was determined by four different methods, analyzing the concentration of surfactant in amniotic fluid L/S ratio was measured planimetrically and densitometrically, foam test and surface tension of the liquor amnii were used on this purpose. 89 normal pregnancies for obtaining normal values served as a basis for comparison with pathological events. A general retardation of fetal lung maturity showed 26 patients with rhesus isoimmunization so as 26 patients with diabetes classes A, B and C (White). In three pregnancies complicated by diabetes class D a remarkable acceleration of fetal lung maturity was obvious. 30 patients with placental insufficiency sui generis presented a very inhomogenous development of the fetal lung, whereas in 35 patients with EPH-gestosis a minute acceleration between 33th and 37th week of gestation was found. A good correlation between all of the used methods for measuring the concentration of surfactant was noted. Best reliability in correct prediction of lung maturity showed the method of measuring the surface-tension of the amniotic fluid.

Amniotic Fluid↗
PubMed1978

[Post partum rubella vaccination and anti-D prevention].

The effectiveness of a routinely performed puerperal rubella vaccination was tested. Additional a possible adverse influence of simultaneously administered anti-D immunoglobulin on the effectiveness of the rubella vaccination was examined. Rubella antibody titers (HHT) in pregnant women were determined; after delivery puerperal women with titers of less or equal 1:16 were selected for rubella vaccination. 2 1/2 to 3 months later rubella antibody titers were done again. 15% of 130 vaccinated women did not show a conversion of the former negative titer or a low titer of 1:8 remained. Also reductions of the antibody titers were seen. When simultaneously rubella vaccination and anti-D immunoglobulin was administered only in 1 case out of 27 patients a negative titer remained after vaccination. The used anti-D immunoglobulin contained rubella antibodies of a titer 1:256 to 1:512; according to experimental studies, this concentration should not have any influence to the immunologic response of rubella vaccination. Our practic results could not confirm the reservations concerning simultaneous rubella vaccination and anti-D prophylaxis.

Erythroblastosis, Fetal↗
PubMed1978

[Anamnesis and course of gestation associated with surgical closure of the cervix (author's transl)].

During a time interval of 2 years in 7% of the gravidae at the First Department of Obstetrics and Gynecology, University of Vienna, a surgical closure of the cervix was performed. The anamnestic and clinical data of these 221 gravidae were compared with a compatible collective of another 221 gravidae without a surgical closure (control-group). In the closuregroup 27,6% were primigravidae. The mean age of the gravidae was 28,8 years and statistically higher than in the control group (25,7 years). Also the mean age of the multigravidae at the time of their first gestation was statistically higher (23,9 years and 22 years respectively). The anamnestic amount of abortion and perinatal mortality was 63,5% and 24,3% respectively, significantly higher was also the anamnestic rate of curettages. In most of the cases surgical closure was indicated by palpation of the cervix, 3 degrees of insufficiency of the cervix were differentiated. There was a great importance of a postsurgical treatment with tocolytic drugs (83% and 10% respectively), but there was also a different mode of application. During the course of gestation a lower frequency of EPH-gestosis (64 gravidae and 90 gravidae respectively) but a higher incidence of diabetes (11 gravidae and 5 gravidae respectively) and a higher incidence of urinary infection (20 gravidae and 7 gravidae respectively) were observed. In patients with a cervical closure a higher rate of rupture of membranes and premature labor were present. Surgical technique and time of closure had no significant influence on the outcome of pregnancy. The rate of success was 86.4%.

Adult↗
PubMed1978

[Premature rupture of the membranes and RDS incidence in prematures (author's transl)].

In the years 1974, 1975 and 1976 495 children were born alive with a birthweight less than 2500 g in the Ist Department of Gynecology and Obstetrics of the University of Vienna. We selected all cases with dystrophy or factors, which were a disposal for RDS, so we got a rest of 188 prematures with a weight from 1000 g to 2500 g. For these children we checked the influence of time of rupture of the membranes (ROM) before delivery to the incidence of RDS. We found a lower incidence of RDS of the newborns when duration of ROM exceeded the time of 12 hours. This fact was statistically significant in the class of premature newborns with a weight of 1500 g to 2000 g. The similar trend was found in 119 dystrophic newborns with a weight between 1000 g to 2500 g, although there was no statistical significance. No influence of duration of labor on the incidence of RDS neither in selected premature nor dystrophic newborns was found.

Birth Weight↗
PubMed1978

[Delivery and post partum period associated with surgical closure of the cervix (author's transl)].

The course of delivery and the post partum period of 211 gravidae with closure of the cervix during pregnancy were compared with a compatible collective of another 221 gravidae without surgical closure. There were significant differences in some respects: The duration of labor (primiparae: 9,2 hours, multiparae: 6,7 hours) was longer than in the control-group (primiparae: 8,1 hours, multiparae: 5,0 hours); the necessity of administration of drugs and the frequency of dystocia (primiparae: 13%, multiparae: 9,2%) was higher than in the control-group (primiparae: 1,0%, multiparae: 0%). These and the higher incidence of lacerations of the cervix (13,4% respectively 1,7%) will be due to the scar, caused by the suture in the cervix. The rate of caesarean section was significantly higher (9,5% respectively 4,1%). There were more complications in disconnecting of the placenta. These and the higher rate of dystrophic newborn could be correlated with anamnestic dispositions of the gravidae. The higher rate of perinatal mortality (9,9%) than in the controlgroup (3,6%) is associated with the higher rate of prematurity (22,1%) than in the control-group (8,5%). A higher incidence of malformation was not observed, but a higher rate of neurological complications in the newborn. The post partum period of the mother was not significantly different than those of the control-group

Apgar Score↗
PubMed1977

[The clinical value of radioimmunological oestradiol assays in the diagnosis of menstrual disorders. Evidence suggesting the presence of an ovarian "inhibin" (author's transl)].

The radioimmunoassay of oestradiol 17 beta (E2) from the blood without chromatography was evaluated in regard to the diagnosis of menstrual cycle disturbances. Two significantly different classes were distinguished, viz. 1. Women with higher E2 values, consisting of three groups: normal controls, cases of oligomenorrhoea, and WHO II (normogonadotropic, clomiphen-positive amenorrhoea). 2. Women with lower E2 values, consisting of two groups: WHO I (hypogonadotropic, clomiphen-negative amenorrhoea) and WHO III (hypergonadotropic amenorrhoea). Within these classes no significant differences were found between the groups. Only values below 43.1 pg/ml can be assigned with 95% certainty to the low-value class and only values above 108.8 pg/ml can be assigned with 95% certainty to the high-value class. The fact that 40% of all E2 values in hypergonadotropic, (i.e. ovarian) amenorrhoea fell within the range of the double standard deviation of the normal group and, likewise, the fact that physiological doses of oestrogen cannot reduce postmenopausal FSH to the level found in women of reproductive age suggest that E2 is not the only FSH-reducing factor, which leads us to postulate the existence of an ovarian "inhibin".

Adult↗
PubMed1977

[Comparative evaluation of methods for predicting fetal lung maturity based on serial amniotic fluid tests (author's transl)].

12 pregnant females in the last trimester were subjected to serial amniocentesis. Although there was medical indication for amniocentesis the pregnancies were normal. All samples were evaluated with four different methods. We used two physical (Wilhelmy balance and foam test) and two chemical (L/S ratio densitometrically and planimetrically measured) methods. The Curves of individual pregnancies were compared with the reference values of 109 samples of amniotic liquid of uncomplicated pregnancies. Reference values for the various techniques reported in the literature are generally based on aggregate data collected from a number of pregnant females, which are then consolidated to obtain mean values for each gestational week. We found a continuous rise of all parameters, both in the reference value and in eight individual pregnancies. Besides we found a strikingly extraordinary run of the curves in four individual pregnancies. Here we recognized a rapid ascent and descent of surfactant concentration within short periods, which were not identical with the reference values. All four methods showed results with a statistical significant conformity, only the foam test showed a little lower significance.

Amniotic Fluid↗